One-pot Three-Component Synthesis of Dihydroquinoxalin-2-amines Containing a Ferrocene unit with the Potential of Biological and Pharmacological Activities

محورهای موضوعی : پلیمر

Neda Aghaei ¹ (Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran)
Nahid Shajari ² (Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran)

تاریخ دریافت : 1398/04/19 تاریخ پذیرش : 1398/04/19 تاریخ انتشار : 1398/04/10

کلید واژه:

چکیده مقاله :

A three-component reaction between 1,2-phenylenediamine, ferrocenecarbaldehyde, and isocyanides in the presence of a catalytic amount of p-toluenesulfonic acid for the synthesis of 3,4-dihydroquinoxalin-2-amine derivatives containing a ferrocene unit is reported. This approach is an effective procedure because the products have a broad spectrum of biological and pharmacological activities such as insecticide, fungicide, herbicide, anthelmintic, antibacterial, antimycobacterial, antiprotozoal, anticancer and antibiotic properties.