The effect of endurance training and curcumin supplement on oxidative stress and memory in Alzheimer's disease
محورهای موضوعی : Journal of Physical Activity and Hormones
Seyedeh Fatemeh Hosseini Kolgoo
1
,
Alireza Elmieh
2
,
Shahram Gholamrezaei Dadsar
3
,
Mohammad Reza Fadaei Chafy
4
1 - Department of Physical Education and Sport Sciences, Ra.C., Islamic Azad university,Rasht,Iran
2 - Department of Physical Education and Sport Science, Ra.C., Islamic Azad University, Rasht, Iran
3 - Department of Physical Education and Sport Sciences, Ra.C., Islamic Azad University, Rasht, Iran
4 - Department of Physical Education and Sport Science, Ra.C., Islamic Azad University, Rasht, Iran
کلید واژه: Alzheimer's disease, oxidative stress, endurance training, curcumin,
چکیده مقاله :
Introduction: Alzheimer’s disease (AD) is the leading cause of dementia worldwide. One of its main pathophysiological mechanisms involves neuronal damage induced by oxidative stress. The present study aimed to investigate the effects of endurance training and curcumin supplementation on oxidative stress and memory function in a rat model of AD.
Material & Methods: In this experimental study, forty rats were randomly divided into six groups: healthy control, sham, AD control, exercise, curcumin, and exercise + curcumin. The experimental groups underwent eight weeks of endurance training and/or received curcumin injections. Memory performance, glutathione peroxidase (GPX) activity, and malondialdehyde (MDA) levels were assessed. Data were analyzed using two-way ANOVA and independent t-tests.
Results: Both exercise and curcumin significantly improved memory performance (p=0.006 and p=0.008), decreased MDA levels (p<0.001), and increased GPX activity (p=0.01 and p<0.001) compared with the AD control group.
Conclusion: These findings suggest that curcumin supplementation and endurance exercise can mitigate oxidative stress and cognitive decline in Alzheimer’s disease rat models.
Introduction: Alzheimer’s disease (AD) is the leading cause of dementia worldwide. One of its main pathophysiological mechanisms involves neuronal damage induced by oxidative stress. The present study aimed to investigate the effects of endurance training and curcumin supplementation on oxidative stress and memory function in a rat model of AD.
Material & Methods: In this experimental study, forty rats were randomly divided into six groups: healthy control, sham, AD control, exercise, curcumin, and exercise + curcumin. The experimental groups underwent eight weeks of endurance training and/or received curcumin injections. Memory performance, glutathione peroxidase (GPX) activity, and malondialdehyde (MDA) levels were assessed. Data were analyzed using two-way ANOVA and independent t-tests.
Results: Both exercise and curcumin significantly improved memory performance (p=0.006 and p=0.008), decreased MDA levels (p<0.001), and increased GPX activity (p=0.01 and p<0.001) compared with the AD control group.
Conclusion: These findings suggest that curcumin supplementation and endurance exercise can mitigate oxidative stress and cognitive decline in Alzheimer’s disease rat models.
1. Wu Y-Y, Kuo H-C. Functional roles and networks of non-coding RNAs in the pathogenesis of neurodegenerative diseases. Journal of Biomedical Science. 2020;27(1):49. DOI: 10.1186/s12929-020-00636-z
2. Calfio C, Gonzalez A, Singh SK, Rojo LE, Maccioni RB. The emerging role of nutraceuticals and phytochemicals in the prevention and treatment of Alzheimer’s disease. Journal of Alzheimer’s disease. 2020;77(1):33-51. DOI: 10.3233/JAD-200443
3. Gauthier-Umaña C, Muñoz-Cabrera J, Valderrama M, Múnera A, Nava-Mesa MO. Acute Effects of Two Different Species of Amyloid‐β on Oscillatory Activity and Synaptic Plasticity in the Commissural CA3‐CA1 Circuit of the Hippocampus. Neural Plasticity. 2020;2020(1):8869526. DOI: 10.1155/2020/8869526
4. Jia Z, Yuan X, Wei J-a, Guo X, Gong Y, Li J, et al. A functionalized octahedral palladium nanozyme as a radical scavenger for ameliorating Alzheimer’s disease. ACS Applied Materials & Interfaces. 2021;13(42):49602-13. DOI: 10.1021/acsami.1c12206
5. Cheignon Cm, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F. Oxidative stress and the amyloid beta peptide in Alzheimer’s disease. Redox biology. 2018;14:450-64. DOI: 10.1016/j.redox.2017.10.014
6. Wollen KA. Alzheimer’s disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Altern Med Rev. 2010;15(3):223-44. PMID: 21155624
7. Bekdash RA. The cholinergic system, the adrenergic system and the neuropathology of Alzheimer’s disease. International Journal of Molecular Sciences. 2021;22(3):1273. DOI: 10.3390/ijms22031273
8. Tönnies E, Trushina E. Oxidative stress, synaptic dysfunction, and Alzheimer’s disease. Journal of Alzheimer’s disease. 2017;57(4):1105-21. DOI: 10.3233/JAD-161088
9. Hernández-Zimbrón LF, Rivas-Arancibia S. Syntaxin 5 Overexpression and β‐Amyloid 1–42 Accumulation in Endoplasmic Reticulum of Hippocampal Cells in Rat Brain Induced by Ozone Exposure. BioMed research international. 2016;2016(1):2125643. DOI: 10.1155/2016/2125643
10. Kancheva VD, Dettori MA, Fabbri D, Alov P, Angelova SE, Slavova-Kazakova AK, et al. Natural chain-breaking antioxidants and their synthetic analogs as modulators of oxidative stress. Antioxidants. 2021;10(4):624. DOI: 10.3390/antiox10040624
11. Peng Y, Chang X, Lang M. Iron homeostasis disorder and Alzheimer’s disease. International journal of molecular sciences. 2021;22(22):12442. DOI: 10.3390/ijms222212442
12. Cassidy L, Fernandez F, Johnson JB, Naiker M, Owoola AG, Broszczak DA. Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics. Complementary therapies in medicine. 2020;49:102294. DOI: 10.1016/j.ctim.2020.102294
13. Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The lancet. 2020;396(10248):413-46. DOI: 10.1016/S0140-6736(20)30367-6
14. Chieffi S, Messina G, Villano I, Messina A, Esposito M, Monda V, et al. Exercise influence on hippocampal function: possible involvement of orexin-A. Frontiers in physiology. 2017;8:85. DOI: 10.3389/fphys.2017.00085
15. Saint-Maurice PF, Coughlan D, Kelly SP, Keadle SK, Cook MB, Carlson SA, et al. Association of leisure-time physical activity across the adult life course with all-cause and cause-specific mortality. JAMA network open. 2019;2(3):e190355-e. DOI: 10.1001/jamanetworkopen.2019.0355
16. Piccialli I, Tedeschi V, Caputo L, D’Errico S, Ciccone R, De Feo V, et al. Exploring the therapeutic potential of phytochemicals in Alzheimer’s disease: Focus on polyphenols and monoterpenes. Frontiers in Pharmacology. 2022;13:876614. DOI: 10.3389/fphar.2022.876614
17. Davinelli S, Sapere N, Zella D, Bracale R, Intrieri M, Scapagnini G. Pleiotropic protective effects of phytochemicals in Alzheimer′ s disease. Oxidative Medicine and Cellular Longevity. 2012;2012(1):386527. DOI: 10.1155/2012/386527
18. Nabavi SF, Sureda A, Dehpour AR, Shirooie S, Silva AS, Devi KP, et al. Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration. Biotechnology advances. 2018;36(6):1768-78. DOI: 10.1016/j.biotechadv.2017.12.001
19. Singh SK, Srivastav S, Yadav AK, Srikrishna S, Perry G. Overview of Alzheimer’s disease and some therapeutic approaches targeting Aβ by using several synthetic and herbal compounds. Oxidative medicine and cellular longevity. 2016;2016(1):7361613. DOI: 10.1155/2016/7361613
20. Kim H, Im YH, Ahn J, Yang J, Choi JY, Lee K-H, et al. Synthesis and in vivo characterization of 18F-labeled difluoroboron-curcumin derivative for β-amyloid plaque imaging. Scientific Reports. 2019;9(1):6747. DOI: 10.1038/s41598-019-43246-y
21. Lee H-J, Jeong M, Na Y-G, Kim S-J, Lee H-K, Cho C-W. An EGF-and curcumin-co-encapsulated nanostructured lipid carrier accelerates chronic-wound healing in diabetic rats. Molecules. 2020;25(20):4610. DOI: 10.3390/molecules25204610
22. Theppawong A, Van de Walle T, Grootaert C, Van Hecke K, Catry N, Desmet T, et al. Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates. ChemistryOpen. 2019;8(2):236-47. DOI: 10.1002/open.201800233
23. Rasouli Z, Ghavami R. Facile approach to fabricate a chemical sensor array based on nanocurcumin–metal ions aggregates: detection and identification of DNA nucleobases. ACS omega. 2020;5(31):19331-41. DOI: 10.1021/acsomega.0c00841
24. Hadizadeh-Bazaz M, Vaezi G, Hojati V. Curcumin attenuates spatial memory impairment by anti-oxidative, anti-apoptosis, and anti-inflammatory mechanism against methamphetamine neurotoxicity in male Wistar rats: Histological and biochemical changes. Neurotoxicology. 2021;84:208-17. DOI: 10.1016/j.neuro.2021.03.010
25. Rajeswari A. Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydro pyridine. European Review for Medical and Pharmacological Sciences. 2006;10(4):157. PMID: 16910349
26. Hashemi SA, Ghadimi Z, Ghaedi H, Hashemi A. The effects of eight weeks of aerobic training with vitamin C on the expression pathway of antioxidants in the hippocampus tissue of TMT induced Alzheimer's disease rats. Brain Research. 2024;1822:148645. DOI: 10.1016/j.brainres.2023.148645
27. Lee K, Gang GG, Kang YG, Jung SS, Park H-G, Jang JH. Alleviation of osteoarthritis-induced pain and motor deficits in rats by a novel device for the intramuscular insertion of cog polydioxanone filament. Applied Sciences. 2021;11(22):10534. DOI: 10.3390/app112210534
28. McKinney JM, Pucha KA, Bernard FC, Brandon Dixon J, Doan TN, Willett NJ. Osteoarthritis early‐, mid‐and late‐stage progression in the rat medial meniscus transection model. Journal of Orthopaedic Research®. 2025;43(1):102-16. DOI: 10.1002/jor.25976
29. Kuyinu EL, Narayanan G, Nair LS, Laurencin CT. Animal models of osteoarthritis: classification, update, and measurement of outcomes. Journal of orthopaedic surgery and research. 2016;11(1):19. DOI: 10.1186/s13018-016-0346-5
30. Ermiş M, Çiftci G. Role of curcumin on beta-amyloid protein, tau protein, and biochemical and oxidative changes in streptozotocin-induced diabetic rats. Naunyn-Schmiedeberg's Archives of Pharmacology. 2024;397(12):9833-44. DOI: 10.1007/s00210-024-03248-8
31. Khurana S, Jain S, Mediratta P, Banerjee B, Sharma K. Protective role of curcumin on colchicine-induced cognitive dysfunction and oxidative stress in rats. Human & experimental toxicology. 2012;31(7):686-97. DOI: 10.1177/0960327111433899
32. Bozorgi AD, Behboudi L, Hosseini SA, Rasoli MH. Effect of voluntary and forced training with royal jelly consumption on learning and spatial memory of rat model of alzheimer’s disease. Jundishapur Journal of Chronic Disease Care. 2020;9(9). DOI: 10.5812/jjcdc.106017
33. Mushtaq A, Anwar R, Ahmad M. Lavandula stoechas (L) a very potent antioxidant attenuates dementia in scopolamine induced memory deficit mice. Frontiers in pharmacology. 2018;9:1375. DOI: 10.3389/fphar.2018.01375
34. Zou X, Feng Z, Li Y, Wang Y, Wertz K, Weber P, et al. Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways. The Journal of nutritional biochemistry. 2012;23(8):994-1006. DOI: 10.1016/j.jnutbio.2011.05.006
35. Fetler L, Amigorena S. Brain under surveillance: the microglia patrol. Science. 2005;309(5733):392-3. DOI: 10.1126/science.1114852
36. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. Journal of Neuroscience. 2005;25(39):8843-53. DOI: 10.1523/JNEUROSCI.2868-05.2005
37. Shao S, Ye X, Su W, Wang Y. Curcumin alleviates Alzheimer’s disease by inhibiting inflammatory response, oxidative stress and activating the AMPK pathway. Journal of Chemical Neuroanatomy. 2023;134:102363. DOI: 10.1016/j.jchemneu.2023.102363
38. Ruan Y, Luo H, Tang J, Ji M, Yu D, Yu Q, et al. Curcumin inhibits oxidative stress and autophagy in C17. 2 neural stem cell through ERK1/2 signaling pathways. Aging Medicine. 2024;7(5):559-70. DOI: 10.1002/agm2.12312
39. Hussain H, Ahmad S, Shah SWA, Ullah A, Rahman SU, Ahmad M, et al. Synthetic mono-carbonyl curcumin analogues attenuate oxidative stress in mouse models. Biomedicines. 2022;10(10):2597. DOI: 10.3390/biomedicines10102597
40. Xu Y, Hu R, He D, Zhou G, Wu H, Xu C, et al. Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up‐regulating SIRT1. Brain and Behavior. 2020;10(7):e01655. DOI: 10.1002/brb3.1655
41. da Luz Scheffer D, Latini A. Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2020;1866(10):165823. DOI: 10.1016/j.bbadis.2020.165823
42. Pinho RA, Silva LA, Pinho CA, Scheffer DL, Souza CT, Benetti M, et al. Oxidative stress and inflammatory parameters after an Ironman race. Clinical Journal of Sport Medicine. 2010;20(4):306-11. DOI: 10.1097/JSM.0b013e3181e8d6d9
43. Zhang X, He Q, Huang T, Zhao N, Liang F, Xu B, et al. Treadmill exercise decreases Aβ deposition and counteracts cognitive decline in APP/PS1 mice, possibly via hippocampal microglia modifications. Frontiers in aging neuroscience. 2019;11:78. DOI: 10.3389/fnagi.2019.00078
44. Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. Journal of Neuroscience. 2005;25(17):4217-21. DOI: 10.1523/JNEUROSCI.0496-05.2005
45. Liu H-l, Zhao G, Zhang H, Shi L-d. Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice. Behavioural brain research. 2013;256:261-72. DOI: 10.1016/j.bbr.2013.08.031
46. Tarumi T, Rossetti H, Thomas BP, Harris T, Tseng BY, Turner M, et al. Exercise training in amnestic mild cognitive impairment: a one-year randomized controlled trial. Journal of Alzheimer’s Disease. 2019;71(2):421-33. DOI: 10.3233/JAD-181175
47. Hamer M, Chida Y. Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychological medicine. 2009;39(1):3-11. DOI: 10.1017/S0033291708003681
48. Yu J-T, Xu W, Tan C-C, Andrieu S, Suckling J, Evangelou E, et al. Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. Journal of Neurology, Neurosurgery & Psychiatry. 2020;91(11):1201-9. DOI: 10.1136/jnnp-2019-321913
49. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. The lancet. 2017;390(10113):2673-734. DOI: 10.1016/S0140-6736(17)31363-6
50. Silva MVF, Loures CdMG, Alves LCV, De Souza LC, Borges KBG, Carvalho MdG. Alzheimer’s disease: risk factors and potentially protective measures. Journal of biomedical science. 2019;26(1):33. DOI: 10.1186/s12929-019-0520-2
51. Lamb SE, Sheehan B, Atherton N, Nichols V, Collins H, Mistry D, et al. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. bmj. 2018;361. DOI: 10.1136/bmj.k1675
52. Mahalakshmi B, Maurya N, Lee S-D, Bharath Kumar V. Possible neuroprotective mechanisms of physical exercise in neurodegeneration. International journal of molecular sciences. 2020;21(16):5895. DOI: 10.3390/ijms21165895
53. Weitz TM, Town T. Microglia in Alzheimer′ s Disease: It′ s All About Context. International journal of Alzheimer’s disease. 2012;2012(1):314185. DOI: 10.1155/2012/314185
54. Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Annals of the rheumatic diseases. 2014;73(7):1323-30. DOI: 10.1136/annrheumdis-2013-204763
55. Mittler R. ROS are good. Trends in plant science. 2017;22(1):11-9. DOI: 10.1016/j.tplants.2016.08.002
