Dispersive Solid Phase Extraction for the Preconcentration of Trace Moxifloxacin in Aqueous and Urine Samples Using β-cyclodextrin Functionalized Magnetic Nanotubes
محورهای موضوعی : نانوAli Moghimi 1 , Hossein Anaraki Ardakani 2
1 - Department of Chemistry, TeMS.C., Islamic Azad University, Tehran, Iran
2 - Department of Chemistry, Ka.C., Islamic Azad University, Karaj, Iran
کلید واژه: β-cyclodextrin, adsorption, Moxifloxacin, SPE, Nanoparticles,
چکیده مقاله :
This project presents a rapid method for the adsorption of low concentrations of Moxifloxacin in aqueous samples using β-cyclodextrin-functionalized magnetic nanotubes (Fe3O4/NT/M). The process involves two phases: the donor phase, which consists of the water containing Moxifloxacin, and the acceptor phase, which includes the functionalized magnetic nanotubes with β-cyclodextrin. The experiment consisted of two steps: extracting Moxifloxacin from the water sample and desorbing it using basic methanol. The adsorption process was described well by the Langmuir isotherm model, indicating a maximum Moxifloxacin adsorption capacity of 30.12 mg/g. The pseudo-second-order kinetic model suggests that the rate of adsorption of Moxifloxacin by Fe3O4/NT/M is limited and governed by a chemisorption process. To optimize the effective parameters, a Central Composite Design (CCD) approach was employed. This method yielded optimal conditions for the adsorbent dose (15 mg), ultrasonic treatment time (21.5 minutes), and elution volume (11.3 mL). The limits of detection and quantification for Moxifloxacin adsorption were determined to be 16.9 µg/L and 55.6 µg/L, respectively, with a linear range established between 1 and 10 mg/L. Ultimately, Fe3O4/NT/BD demonstrated significant potential for the adsorption of Moxifloxacin from biological samples.
This project presents a rapid method for the adsorption of low concentrations of Moxifloxacin in aqueous samples using β-cyclodextrin-functionalized magnetic nanotubes (Fe3O4/NT/M). The process involves two phases: the donor phase, which consists of the water containing Moxifloxacin, and the acceptor phase, which includes the functionalized magnetic nanotubes with β-cyclodextrin. The experiment consisted of two steps: extracting Moxifloxacin from the water sample and desorbing it using basic methanol. The adsorption process was described well by the Langmuir isotherm model, indicating a maximum Moxifloxacin adsorption capacity of 30.12 mg/g. The pseudo-second-order kinetic model suggests that the rate of adsorption of Moxifloxacin by Fe3O4/NT/M is limited and governed by a chemisorption process. To optimize the effective parameters, a Central Composite Design (CCD) approach was employed. This method yielded optimal conditions for the adsorbent dose (15 mg), ultrasonic treatment time (21.5 minutes), and elution volume (11.3 mL). The limits of detection and quantification for Moxifloxacin adsorption were determined to be 16.9 µg/L and 55.6 µg/L, respectively, with a linear range established between 1 and 10 mg/L. Ultimately, Fe3O4/NT/BD demonstrated significant potential for the adsorption of Moxifloxacin from biological samples.
