Novel Correlation among C3, h-CRP, and WBC in the Pathogenesis of ST-elevation Myocardial Infarction
محورهای موضوعی :Hassan Sarhan Sachit 1 , Ali Mohammed Brakat 2 , Gassan Jabbar Auda 3 , Raed Fanoukh Aboqader 4 , Adnan Taan Thamer 5
1 - College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
2 - College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
3 - College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
4 - Al-Aouadi College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
5 - College of Medicine, Al-Ayen Iraqi University, AUIQ, An Nasiriyah, Iraq
کلید واژه: C3, hs-CRP, WBC, LDL, STEMI,
چکیده مقاله :
ST-segment elevation myocardial infarction (STEMI) is a major contributor to global morbidity and mortality, necessitating a deeper understanding of its pathophysiology. This study aimed to evaluate the correlation between white blood cell (WBC) counts, complement component C3, high-sensitivity C-reactive protein (hs-CRP), and high- and low-density lipoprotein levels in patients diagnosed with ST-segment elevation myocardial infarction (STEMI) compared to a healthy control group. A total of 60 participants were included, comprising 30 individuals diagnosed with STEMI and 30 healthy controls, who were recruited from outpatient clinics in Nassiyria Province, Iraq, between January and December 2024. Blood samples were collected and analyzed for WBC counts, hs-CRP, C3, and LDL levels using standardized laboratory techniques, including ELISA and spectrophotometry. The results showed a significant increase in hs-CRP (P<0.0001), WBC (P<0.0001), and LDL (P<0.0001) levels in the STEMI group compared to the control group, accompanied by a notable decrease in C3 levels (P<0.0001). A positive correlation was notably observed between BMI and increased levels of LDL (r = 0.939, P < 0.01). Additionally, a positive correlation was remarkably observed between BMI and increased levels of WBC (r= 0.815; P<0.01) and h-CRP (r= 0.805; P<0.01), but a negative correlation was detected between BMI and levels of HDL (r= - 0.0.937; P<0.01) and C3 (r= -0.733; P<0.01) These findings suggest that elevated inflammatory markers and lipid profiles may play a crucial role in the immunopathogenesis of STEMI. The study highlights the importance of monitoring these biomarkers in clinical settings, as they may provide insights into the inflammatory processes associated with myocardial infarction. Furthermore, the correlation among these markers could inform potential therapeutic strategies to mitigate inflammation and improve patient outcomes post-STEMI. Overall, this research contributes to the understanding of the complex interplay between lipid metabolism and inflammatory responses in the context of acute myocardial infarction, emphasizing the need for further investigation into targeted interventions for high-risk populations.
ST-segment elevation myocardial infarction (STEMI) is a major contributor to global morbidity and mortality, necessitating a deeper understanding of its pathophysiology. This study aimed to evaluate the correlation between white blood cell (WBC) counts, complement component C3, high-sensitivity C-reactive protein (hs-CRP), and high- and low-density lipoprotein levels in patients diagnosed with ST-segment elevation myocardial infarction (STEMI) compared to a healthy control group. A total of 60 participants were included, comprising 30 individuals diagnosed with STEMI and 30 healthy controls, who were recruited from outpatient clinics in Nassiyria Province, Iraq, between January and December 2024. Blood samples were collected and analyzed for WBC counts, hs-CRP, C3, and LDL levels using standardized laboratory techniques, including ELISA and spectrophotometry. The results showed a significant increase in hs-CRP (P<0.0001), WBC (P<0.0001), and LDL (P<0.0001) levels in the STEMI group compared to the control group, accompanied by a notable decrease in C3 levels (P<0.0001). A positive correlation was notably observed between BMI and increased levels of LDL (r = 0.939, P < 0.01). Additionally, a positive correlation was remarkably observed between BMI and increased levels of WBC (r= 0.815; P<0.01) and h-CRP (r= 0.805; P<0.01), but a negative correlation was detected between BMI and levels of HDL (r= - 0.0.937; P<0.01) and C3 (r= -0.733; P<0.01) These findings suggest that elevated inflammatory markers and lipid profiles may play a crucial role in the immunopathogenesis of STEMI. The study highlights the importance of monitoring these biomarkers in clinical settings, as they may provide insights into the inflammatory processes associated with myocardial infarction. Furthermore, the correlation among these markers could inform potential therapeutic strategies to mitigate inflammation and improve patient outcomes post-STEMI. Overall, this research contributes to the understanding of the complex interplay between lipid metabolism and inflammatory responses in the context of acute myocardial infarction, emphasizing the need for further investigation into targeted interventions for high-risk populations.
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