مطالعه اثرات کتوپروفن و فنیل بوتازون در روند ترمیم نقیصه‌ي تجربی استخوان خرگوش براساس یافته‌های رادیولوژی و هیستوپاتولوژی
محورهای موضوعی : پاتوبیولوژی مقایسه ایسماسادات رضائی 1 , سیامک علیزاده 2 , محمدرضا حسینچی 3
1 - دانش‌آموخته دکترای عمومی دامپزشكي، دانشکده دامپزشکي، واحد ارومیه، دانشگاه آزاد اسلامي، ارومیه، ايران.
2 - استادیار گروه علوم درمانگاهی ، واحد نقده، دانشگاه آزاد اسلامی، نقده، ایران
3 - استادیار گروه علوم پایه، دانشکده دامپزشکي، واحد ارومیه، دانشگاه آزاد اسلامي، ارومیه، ايران.
کلید واژه: فنیل بوتازون, کتوپروفن, خرگوش, نقیصه تجربی, هیستوپاتولوژی,
چکیده مقاله :
داروهاي ضدالتهاب غیر استروئیدی نظیر کتوپروفن و فنیل بوتازون از داروهاي معمول برای مدیریت درد در حین و متعاقب اعمال جراحی در انسان و حیوان می‌باشند. هدف از این تحقیق بررسی اثرات این دو دارو بر روند ترمیم طبیعی استخوان زندزبرین خرگوش متعاقب نقیصه‌ي تجربی بود. در این تحقیق از 15 سر خرگوش نر سفید نژاد نیوزیلندي در سه گروه کنترل، کتوپروفن و فنیل بوتازون استفاده شد. متعاقب بی‌هوشی هر خرگوش نقیصه‌ای به قطر و عمق 3 میلی‌متر در استخوان زندزبرین دست چپ آن ایجاد گردید و التیام نقیصه با تهیه نمونه‌های هیستوپاتولوژی و کلیشه‌های رادیوگرافی در روزهاي 7، 14، 21، 35 و 42 بررسی گردید. بر اساس نتایج این مطالعه آغاز روند پر شدن نقیصه در گروه کنترل و کتوپروفن از روز 14 پس از جراحی و در گروه فنیل بوتازون از روز 21 بود. میزان تشکیل کالوس در گروه کنترل در روز 35 به صورت معنی‌داری بیش از روزهای 14 و 21 بود (05/0p≤) در صورتی که در سایر گروه‌ها تفاوت معنی‌داری مشاهده نشد. در روزهای 14 و 21 گروه کتوپروفن نسبت به گروه فنیل بوتازون از نظر تشکیل کالوس و پرشدگی نقیصه، میانگین امتیازی بیشتری کسب نمود اما این میانگین امتیازی در گروه فنیل بوتازون در روز 35 بیش از گروه کتوپروفن بود و بعد از آن این نسبت تا انتهای مطالعه در گروه کتوپروفن بیشتر بود. این مطالعه نشان داد که کتوپروفن نسبت به فنیل بوتازون تأثیر کمتری در به تعویق انداختن روند ترمیم استخوان دارد.
Non-steroidal anti-inflammatory drugs such as ketoprofen and phenylbutazone are common drugs for pain management during and after surgery in humans and animals. The current study aimed to evaluate the effects of these two drugs on the normal healing process of rabbit radius bone following the experimental defect. In this cross-sectional descriptive study used 15 New Zealand white male rabbits in the control, ketoprofen and phenylbutazone groups. Following anesthetization of the animal, a defect with a diameter and depth of 3 mm was created in its right radius. Defect healing was evaluated by preparing histopathology samples and taking radiographs on days 7, 14, 21, 35 and 42. According to the results of this study, the beginning of the process of filling the defect in the control and ketoprofen groups was on the 14th day and in the phenylbutazone group on the 21st day after surgery. The amount of callus formation in the control group on day 35 was significantly higher than days 14 and 21 (p≤0.05), while no significant difference was observed in other groups. On days 14 and 21, in terms of callus formation and defect filling, the ketoprofen group had a higher mean score than the phenylbutazone group. This average score in the phenylbutazone group on day 35 was more than the ketoprofen group, and after that this ratio was higher in the ketoprofen group until the end of the study. This study showed that ketoprofen was less effective in delaying bone healing than phenylbutazone.
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