Caffeine Intake: Insights into Its Effects on Diabetes, Hypertension, and Heart Failure

Bahador Bagheri ¹ ( Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran )
Mohammad Amin Nochian ² ( Student Research Committee, School of Nursing and Midwifery, Semnan University of Medical Sciences, Semnan, Iran )
Amir Abbas Saeedi ³ ( Student Research Committee, School of Nursing and Midwifery, Semnan University of Medical Sciences, Semnan, Iran )
Saeedeh Haratian ⁴ ( Student Research Committee, School of Nursing and Midwifery, Semnan University of Medical Sciences, Semnan, Iran )
Kimia Bagheri ⁵ ( London North West University Healthcare NHS Trust (LNWH), United Kingdom )
Sara Bahramivand ⁶ ( Woodlands Health Centre, London, United Kingdom )
Anna Abdolshahi ⁷ ( Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran )

تاریخ ارسال : 1403/11/03 تاریخ تایید : 1404/07/28

کلید واژه: Caffeine, Coffee, Consumption, Diabetes, Intake,

چکیده مقاله :

Caffeine is one of the major pharmacologically active substance intakes from food products all over the world. Large-scale intake of any type of coffee, tea, and beverages may be inducing the intake of large quantities of caffeine in the population. Harmful effects of caffeine ingestion on human health are dependent on the way of intake of caffeinated products because the time and the composition. The role of caffeine intake on chronic illness such as diabetes, hypertension, and heart failure has emerged as a significant public health matter. The review aims to clarify the impact of caffeine on this kind of illness and suggest ways of maximizing utilization. As diabetes and related illnesses rise in prevalence, it is imperative to stay in control of caffeine intake. Additionally, information about the effect of caffeine on hypertension, being a significant risk factor must be considered for the prevention of adverse cardiovascular outcomes. Based on evidenced data, moderate daily consumption of caffeine-contained product mainly coffee up to the defined quantity of caffeine is not associated with diseases to diabetes, hypertension, and heart failure. Certainly, excessive use can increase severe health threats. This study examines the acute and chronic effects of caffeine on glucose metabolism, blood pressure regulation, and cardiovascular disease. These findings highlight the importance of well-balanced public health messages regarding the use and consumption of caffeine.

چکیده انگلیسی :

منابع و مأخذ:

1. Lee S., Min J.y., Min K.b., 2020. Caffeine and caffeine metabolites in relation to insulin resistance and beta cell function in US adults. Nutrients. 12(6), 1783. https://doi.org/10.3390/nu12061783
2. Kolb H., Martin S., Kempf K., 2021. Coffee and lower risk of type 2 diabetes: arguments for a causal relationship. Nutrients. 13 (4), 1144. https://doi.org/10.3390/nu13041144
3. Jayedi A., Soltani S., Abdolshahi A., Shab-Bidar S., 2021. Fish consumption and the risk of cardiovascular disease and mortality in patients with type 2 diabetes: a dose-response meta-analysis of prospective cohort studies. Critical Reviews in Food Science and Nutrition. 61(10), 1640-1650. https://doi.org/10.1080/10408398.2020.1764486.
4. Yao H., Li L., Wang X., Wang Z., 2024. Association of caffeine intake with all-cause and cardiovascular mortality in diabetes and prediabetes. Diabetology & Metabolic Syndrome. 16 (1), 177. https://doi.org/10.1186/s13098-024-01417-6
5. Rodak K., Kokot I., Kratz E.M., 2021. Caffeine as a factor influencing the functioning of the human body—friend or foe? Nutrients. 13(9), 3088. https://doi.org/10.3390/nu13093088
6. Unsal S., Sanlier N., 2025. Longitudinal Effects of Lifetime Caffeine Consumption on Levels of Depression, Anxiety, and Stress: A Comprehensive Review. Current Nutrition Reports. 14(1), 1-14.
https://doi.org/10.1007/s13668-025-00616-5
7. Reddy V.S., Shiva S., Manikantan S., Ramakrishna S., 2024. Pharmacology of caffeine and its effects on the human body. European Journal of Medicinal Chemistry Reports. 10, 100138. https://doi.org/10.1016/j.ejmcr.2024.100138
8. Kukkonen A., Hantunen S., Voutilainen A., Ruusunen A., Uusitalo L., Backman K., Voutilainen R., Pasanen M., Kirjavainen P. V., Keski-Nisula L., 2024. Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes–Kuopio Birth Cohort. Primary Care Diabetes. 18(3), 362-367. https://doi.org/10.1016/j.pcd.2024.02.005
9. Said M. A., van De Vegte Y. J., Verweij N., van Der Harst P., 2020. Associations of observational and genetically determined caffeine intake with coronary artery disease and diabetes mellitus. Journal of the American Heart Association. 9(24), 016808.
https://doi.org/10.1161/JAHA.120.016808
10. Vali M. H., Ashoorey F., Bahraminasab M., Abdolshahi A., Arab S., 2023. Association of History of Diabetes and Hypertension with Clinical Findings and Length of Hospital Stay in COVID-19 Patients. Middle East Journal of Rehabilitation and Health Studies. 11(4), 139208. https://doi.org/10.5812/mejrh-139208
11. Jayedi A., Soltani S., Abdolshahi A., Shab-Bidar S., 2020. Healthy and unhealthy dietary patterns and the risk of chronic disease: an umbrella review of meta-analyses of prospective cohort studies. British Journal of Nutrition. 124(11), 1133-1144.
https://doi.org/10.1017/S0007114520002330
12. Albar S. A., Almaghrabi M.A., Bukhari R. A., Alghanmi R.H., Althaiban M.A., Yaghmour K.A., 2021. Caffeine sources and consumption among Saudi adults living with diabetes and its potential effect on HbA1c. Nutrients. 13(6), 1960. https://doi.org/10.3390/nu13061960.
13. Khodadadi D., Azimi F., Eghbal Moghanlou A., Gursoy R., Demirli A., Jalali P., Behdari R., Seyedheydari M., 2025. Habitual Caffeine Consumption and Training Status Affect the Ergogenicity of Acute Caffeine Intake on Exercise Performance. Sports Health, 19417381251315093. https://doi.org/ 10.1177/19417381251315093
14. Sevilla-Gonzalez M., Tobias D.K., LeBoff M., Demler O., Pradhan A.D., Mora S., Lee I.M., Buring J., Manson J., Li J., 2024. Abstract P429: Coffee Intake is Associated With Enhanced Insulin Sensitivity, Lower Post-Load Glucose Responses, and Lower Truncal Adiposity. Circulation. 149(1), 429.
15. Yang J., Tobias D. K., Li S., Bhupathiraju S.N., Ley S.H., Hinkle S.N., Qian F., Chen Z., Zhu Y., Bao W., 2022. Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes–a prospective study. The American journal of clinical nutrition. 116(6), 1693-1703. https://doi.org/10.1093/ajcn/nqac241
16. Li W., Xie Y., Jiang L., 2025. Coffee and tea consumption on the risk of osteoporosis: a meta-analysis. Frontiers in nutrition. 12, 1559835. https://doi.org/10.3389/fnut.2025.1559835
17. Ouyang J., Wu P., Chen L., Tong J., Yan S., Li J., Tao F., Huang K., 2025. Impact of tea and coffee consumption during pregnancy on children’s cognitive development. Scientific Reports. 15(1), 8832. https://doi.org/ 10.1038/s41598-025-91982-1
18. Liu M., Zhang Y., Ye Z., Yang S., Zhang Y., He P., Zhou C., Qin X., 2025. Evaluation of the Association Between Coffee Consumption, Including Type (Instant, Ground), and Addition of Milk or Sweeteners and New-Onset Hypertension and Potential Modifiers. Journal of the Academy of Nutrition and Dietetics. 125 (5), 641-653.https://doi.org/10.1016/j.jand.2024.10.013
19. Zhang F., Zhang A., Tao J., Zhang M., Liang C., 2025. Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008. Frontiers in nutrition. 11, 1511607. https://doi.org/10.3389/fnut.2024.1511607
20. Kujawska A., Kujawski S., Hajec W., Skierkowska N., Kwiatkowska M., Husejko J., Newton J. L., Simoes J. A., Zalewski P., Kędziora-Kornatowska K., 2021. Coffee consumption and blood pressure: results of the second wave of the cognition of older people, education, recreational activities, nutrition, comorbidities, and functional capacity studies (COPERNICUS). Nutrients. 13(10), 3372. https://doi.org/ 10.3390/nu13103372
21. Surma S., Oparil S., 2021. Coffee and arterial hypertension. Current hypertension reports. 23 (7), 38. https://doi.org/10.1007/s11906-021-01156-3
22. Vignesh A., Amal T.C., Shanmugam A., Vasanth K., Selvakumar S., 2025. Effects of dietary approaches to prevent hypertension and enhance cardiovascular health. Discover Food. 5(1), 1-19. https://doi.org/10.1007/s44187-025-00278-w.
23. West K. S., Helwig N.J., Schwager L.E., Hart T.W., Zucker A.C., Venenga J.S., Flores M., Jenkins N.D., 2025. Habitual preexercise caffeine supplementation prevents exercise training-induced attenuation of exercising systolic blood pressure and double product. Journal of Applied Physiology. 138 (2), 358-365. https://doi.org/10.1152/japplphysiol.00874.2024.
24. Ehret G.B. 2024. Genetics of hypertension. Hypertension. 87-92. https://doi.org/10.1016/B978-0-323-88369-6.00006-2
25. Bhattacharya M., Nandi S., Aich A., Chakraborty S., 2025. An overview of caffeine: The wonder molecule of non-alcoholic beverage. Journal of Pharmacognosy and Phytochemistry. 14 (2), 115-120. https://doi.org/10.22271/phyto.2025.v14.i2b.15282
26. Tian Y. L., Liu X., Yang M. Y., Wu Y. H., Yin F.Q., Zhang Z.T., Zhang C., 2025. Association between caffeine intake and fat free mass index: a retrospective cohort study. Journal of the International Society of Sports Nutrition. 22(1), 2445607. http://doi.org/10.1080/15502783.2024.2445607
27. Zhang S., Xiang B., Su X., Zhou Y., Zhao Y., Zhou X., 2024. Is coffee, tea, and red wine consumption beneficial for individuals with hypertension? Postgraduate mMedical Journal. 100(1186), 603-610. https://doi.org/10.1093/postmj/qgae039
28. Miranda A.M., Goulart A.C., Benseñor I.M., Lotufo P.A., Marchioni D.M., 2021. Coffee consumption and risk of hypertension: A prospective analysis in the cohort study. Clinical Nutrition. 40(2), 542-549. https://doi.org/10.1016/j.clnu.2020.05.052
29. Chen S., Li J., Gao M., Li D., Shen R., Lyu L., Shen J., Shen X., Fu G., Wei T., 2022. Association of caffeine intake with all-cause and cardiovascular mortality in elderly patients with hypertension. Frontiers in Nutrition. 9, 1023345.
30. Haghighatdoost F., Hajihashemi P., de Sousa Romeiro A. M., Mohammadifard N., Sarrafzadegan N., de Oliveira C., Silveira E. A., 2023. Coffee consumption and risk of hypertension in adults: Systematic review and meta-analysis. Nutrients. 15(13), 3060. https://doi.org/ https://doi.org/
31. Han M., Oh Y., Myung S.K., 2022. Coffee intake and risk of hypertension: a meta-analysis of cohort studies. Journal of Korean Medical Science. 37(45), 332. https://doi.org/ 10.3346/jkms.2022.37.e332
32. Wang K., Li Z., He J., 2024. Association of caffeine consumption with all‐cause and cause specific mortality in adult Americans with hypertension. Food Science & Nutrition. 12(6), 4185-4195. https://doi.org/ 10.1002/fsn3.4079
33. Yamaji T., Harada T., Hashimoto Y., Nakano Y., Kajikawa M., Yoshimura K., Goto C., Mizobuchi A., Tanigawa S., Yusoff F. M., 2022. Relationship of daily coffee intake with vascular function in patients with hypertension. Nutrients. 14(13), 2719. https://doi.org/ 10.3390/nu14132719
34. Chei C.L., Loh J.K., Soh A., Yuan J.M., Koh W.P., 2018. Coffee, tea, caffeine, and risk of hypertension: the Singapore Chinese Health Study. European Journal of Nutrition. 57, 1333-1342. https://doi.org/ 10.1007/s00394-017-1412-4
35. Ke D., Wang Y., Hou Y., Shao W., Ke J., Zhang X., Yang H., He Z., Lu Z., 2025. Sex differences in the associations of water, coffee and tea consumption with cardiovascular diseases: a prospective cohort study. Frontiers in Nutrition. 12, 1530908. https://doi.org/ 10.3389/fnut.2025.1530908
36. Sharma V.K., Sharma A., Verma K.K., Gaur P. K., Kaushik R., Abdali B., 2023. A comprehensive review on pharmacological potentials of caffeine. Journal of Applied Pharmaceutical Sciences and Research. 6(3), 16-26. https://doi.org/ 10.31069/japsr.v6i3.04
37. Chieng D., Canovas R., Segan L., Sugumar H., Voskoboinik A., Prabhu S., Ling L.H., Lee G., Morton J.B., Kaye D.M., 2022. Effects of habitual coffee consumption on incident cardiovascular disease, arrhythmia, and mortality: findings from UK Biobank. Journal of the American College of Cardiology. 79(9), 1455-1455.
38. Mendoza M.F., Sulague R. M., Posas-Mendoza T., Lavie C.J., 2023. Impact of coffee consumption on cardiovascular health. Ochsner Journal. 23(2), 152-158. https://doi.org/10.31486/toj.22.0073
39. Park Y., Cho H., Myung S.K., 2023. Effect of coffee consumption on risk of coronary heart disease in a systematic review and meta-analysis of prospective cohort studies. The American Journal of Cardiology. 186, 17-29. https://doi.org/10.1016/j.amjcard.2022.10.010
40. Bodar V., Chen J., Sesso H.D., Gaziano J.M., Djoussé L., 2020. Coffee consumption and risk of heart failure in the Physicians' Health Study. Clinical nutrition ESPEN. 40, 133-137. https://doi.org/10.1016/j.clnesp.2020.09.216
41. Li H., Hastings M. H., Rhee J., Trager L. E., Roh J. D., Rosenzweig A., 2020. Targeting age-related pathways in heart failure. Circulation Research. 126(4), 533-551. https://doi.org/10.1161/CIRCRESAHA.119.315889
42. Zhou H., Li J., Zhang C., Huang Y., Jiang H., Chen L., 2025. Impact of Coffee Consumption on Mortality in Patients with Cardiovascular and Cerebrovascular Diseases: A Cohort Study. Nutrition, Metabolism and Cardiovascular Diseases. 35(7), 103855. https://doi.org/10.1016/j.numecd.2025.103855
43. Stevens L.M., Linstead E., Hall J.L., Kao D.P., 2021. Association between coffee intake and incident heart failure risk: a machine learning analysis of the FHS, the ARIC study, and the CHS. Circulation: Heart Failure. 14(2), 006799. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006799
44. Tikhonoff V., Casiglia E., 2023. Prognostic cardiovascular cut-off values of dietary caffeine in a cohort of unselected men and women from general population. Nutrition, Metabolism and Cardiovascular Diseases. 33(11), 2160-2168. https://doi.org/10.1016/j.numecd.2023.07.006
45. Malani S., Pathak G., 2023. Characterizing the Impact of Caffeine on Heart Arrhythmias. Open Journal of Preventive Medicine. 13 (11), 285-295.
46. Bjelıca B., Aksovıć N., Zelenović M., Pržulj R., Radenkovic O., 2023. Effect of caffeine on the cardiovascular system and performance: A systematic review. Turkish Journal of Kinesiology. 9(2), 125-132. https://doi.org/10.31459/turkjkin.1263307
47. de Souza J.G., Del Coso J., Fonseca F.d.S., Silva B.V.C., de Souza D.B., da Silva Gianoni R.L., Filip-Stachnik A., Serrão J. C., Claudino J. G., 2022. Risk or benefit? Side effects of caffeine supplementation in sport: a systematic review. European journal of nutrition. 61 (8), 3823-3834. https://doi.org/10.1007/s00394-022-02874-3
48. Bougrine H., Ammar A., Salem A., Trabelsi K., Żmijewski P., Jahrami H., Chtourou H., Souissi N., 2024. Effects of Different Caffeine Dosages on Maximal Physical Performance and Potential Side Effects in Low-Consumer Female Athletes: Morning vs. Evening Administration. Nutrients. 16(14), 2223. https://doi.org/10.3390/nu16142223
49. Kharaba Z., Sammani N., Ashour S., Ghemrawi R., Al Meslamani A.Z., Al-Azayzih A., Buabeid M.A., Alfoteih Y., 2022. Caffeine consumption among various university students in the UAE, exploring the frequencies, different sources and reporting adverse effects and withdrawal symptoms. Journal of Nutrition and Metabolism. 2022(1), 5762299. https://doi.org/10.1155/2022/5762299
50. Soós R., Gyebrovszki Á., Tóth Á., Jeges S., Wilhelm M., 2021. Effects of caffeine and caffeinated beverages in children, adolescents and young adults: short review. International Journal of Environmental Research and Public Health. 18(23), 12389.
https://doi.org/10.3390/ijerph182312389
51. Kapellou A., King A., Graham C.A., Pilic L., Mavrommatis Y., 2023. Genetics of caffeine and brain-related outcomes–a systematic review of observational studies and randomized trials. Nutrition Reviews. 81(12), 1571-1598. https://doi.org/10.1093/nutrit/nuad029
52. Myers J.P., Johnson D.A., McVey D.E. 2020. Caffeine in the modulation of brain function Caffeine and Behavior: Current Views & Research Trends. 17-30.
53. Fiani B., Zhu L., Musch B. L., Briceno S., Andel R., Sadeq N., Ansari A.Z., Briceno S.A., 2021. The neurophysiology of caffeine as a central nervous system
stimulant and the resultant effects on cognitive function. Cureus. 13(5), 15032. 10.7759/cureus.15032
54. Bessada S.M., Alves R.C., Oliveira M.B.P., 2018. Caffeine-based food supplements and beverages: Trends of consumption for performance purposes and safety concerns. Food Research International. 109, 310-319. https://doi.org/10.1016/j.foodres.2018.04.050
55. Foudah A.I., Shakeel F., Salkini M.A., Alshehri S., Ghoneim M.M., Alam P., 2022. A green high-performance thin-layer chromatography method for the determination of caffeine in commercial energy drinks and formulations. Materials. 15(9), 2965.
https://doi.org/10.3390/ma1509296

Caffeine Intake: Insights into Its Effects on Diabetes, Hypertension, and Heart Failure

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