اثر تمرین تناوبی شدید و مصرف مکمل کندر بر سطح سایتوکاین¬های التهابی و فاکتور نوروتروفیک مشتق از مغز در بافت هیپوکامپ موش‌های پیر
محورهای موضوعی : فصلنامه زیست شناسی جانوری
جعفر قربانی
1
,
سیدرضا عطارزاده حسینی
2
,
امیر رشید لمیر
3
,
محمد مسافری ضیاءالدینی
4
1 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
2 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
3 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
4 - گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی دانشگاه فردوسی مشهد، ایران
کلید واژه: پیری, تمرین تناوبی شدید, کندر, التهاب نورونی, فاکتور نوروتروفیک,
چکیده مقاله :
امروزه از فعالیت ورزشی و مصرف گیاهان دارای خاصیت ضداکسایشی به عنوان تعدیل کننده التهاب پیری برای پیشگیری و درمان بیماریهای وابسته به التهاب نام میبرند. هدف تحقیق حاضر، بررسی اثر تمرین تناوبی شدید و مصرف مکمل کندر بر سطح سایتوکاینهای التهابی و فاکتورنوروتروفیک مشتق از مغز در بافت هیپوکامپ موش‌های پیر بود. نمونه آماری تحقیق شامل 28 سر موش صحرایی نرنژاد ویستار در چهار گروه تمرین تناوبی+ دارونما، تمرین تناوبی+ مکمل کندر، مکمل کندر و شم قرارگرفتند. تمرین تناوبی شدید روی تردمیل، پنج روز در هفته به مدت شش هفته اجرا شد. گروه‌های مکمل، طی دوره مداخله 50 میلیگرم (به ازای هر کیلوگرم وزن بدن) محلول کندر به صورت گاواژ دریافت کردند. پس از بیهوشی، کالبد شکافی انجام و سطوح TNF-α، IL-6و BDNF بافت هیپوکامپ اندازهگیری شد. نتایج نشان داد که براساس آزمون تحلیل کروسکال والیس تفاوت رتبههای بین گروهی سطوح TNF-α، IL-6 و BDNF بافت هیپوکامپ موش‌های صحرایی پیر نر به لحاظ آماری معنی دار نبود (05/0 <p ). درنتیجه به نظر میرسد تمرین تناوبی شدید و مصرف مکمل کندر نمی‌تواند تاثیر معناداری بر سطوح سایتوکاین های التهابی و فاکتور نوروتروفیک مشتق از مغز بافت هیپوکامپ ایجاد نماید.
Today, sports activity and the consumption of plants with antioxidant properties are considered as modulators of aging inflammation for the prevention and treatment of inflammation-related diseases. The purpose of this research was to investigate the effect of high intensity interval training and frankincense (Boswellia) supplementation on the level of inflammatory cytokines and brain-derived neurotrophic factor in the hippocampal tissue of aged rats. The statistical sample of the study included 28 aged male Wistar rats who were divided into four groups: interval training + placebo, interval training + Boswellia supplement, Boswellia supplement and sham. High intensity interval training on a treadmill was performed five days a week for six weeks. Supplemental groups received 50 mg frankincense solution (per kilogram of body weight) by gavage during the intervention period. After anesthesia, a necropsy was performed and the levels of TNF-α, IL-6, and BDNF in the hippocampal tissue were measured. The results showed that according to the Kruskal-Wallis analysis, the difference between the ranks of the levels of TNF-α, IL-6 and BDNF in the hippocampus tissue of aged male rats was not statistically significant (p > 0.05). As a result, it seems that high intensity interval training and Boswellia supplement cannot cause a significant difference on the levels of inflammatory cytokines and Brain-derived neurotrophic factor in the hippocampus tissue.
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