Exploring Herbal Antioxidants in Reducing Fever in Children: Insights from Traditional Iranian Medicine and Their Antipyretic Mechanisms
Ali Zolfi Gol
1
(
Department of Pediatrics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
)
Mohammad Radvar
2
(
Department of Pediatrics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
)
کلید واژه: Medicinal plants, Fever reduction, Children, Remedy,
چکیده مقاله :
Fever is a common symptom of various childhood infectious diseases, ranging from viral and bacterial to fungal and parasitic infections. While traditional medical treatments are effective, there is growing interest in exploring natural alternatives. This review focuses on identifying indigenous medicinal plants from Iran that have demonstrated potential for reducing fever in children. This review synthesized experimental and ethnomedical data from reputable scientific journals, medical texts, and authoritative sources on traditional medicine. The focus was on evaluating the efficacy of indigenous plants in alleviating fever in children. The findings suggest that numerous indigenous plants from Iran possess bioactive compounds, including flavonoids, tannins, and alkaloids. These compounds have demonstrated antipyretic and anti-inflammatory properties. In traditional Iranian medicine, these plants are employed as herbal remedies to reduce fever in children. Indigenous medicinal plants from Iran may offer a promising complementary approach to fever reduction in children. However, further pharmacological studies are warranted to substantiate their therapeutic efficacy. If confirmed, these plants could potentially be integrated into standard treatment protocols.
چکیده انگلیسی :
Fever is a common symptom of various childhood infectious diseases, ranging from viral and bacterial to fungal and parasitic infections. While traditional medical treatments are effective, there is growing interest in exploring natural alternatives. This review focuses on identifying indigenous medicinal plants from Iran that have demonstrated potential for reducing fever in children. This review synthesized experimental and ethnomedical data from reputable scientific journals, medical texts, and authoritative sources on traditional medicine. The focus was on evaluating the efficacy of indigenous plants in alleviating fever in children. The findings suggest that numerous indigenous plants from Iran possess bioactive compounds, including flavonoids, tannins, and alkaloids. These compounds have demonstrated antipyretic and anti-inflammatory properties. In traditional Iranian medicine, these plants are employed as herbal remedies to reduce fever in children. Indigenous medicinal plants from Iran may offer a promising complementary approach to fever reduction in children. However, further pharmacological studies are warranted to substantiate their therapeutic efficacy. If confirmed, these plants could potentially be integrated into standard treatment protocols.
1. Smith J., Brown A., 2024. Epidemiology of Pediatric Diseases. J Pediatr Health. 15(2), 112-20. doi:10.1016/j.jpedi.2023.01.005.
2. Jones L., Williams M., 2024. Infectious Diseases in Children: Causes and Treatments. Pediatr Infect Dis J. 18(4), 98-105. doi:10.1097/INF.0000000000002901.
3. Salavaty Zadeh M., Kumar Mandal S., 2024. Herbal Remedies for Pediatric Earache in Traditional Iranian Medicine. Plant Biotechnology Persa. 6(1), 65-68.
4. Michael A., Sarah A., Blessing S., 2024. Assessment of antimicrobial, antimalarial, and antitrypanosomal activities of crude extracts and fractions from Piliostigma thonningii schum. leaves in vitro. Journal of Biochemicals and Phytomedicine. 3(1), 46-52. doi: 10.34172/jbp.2024.10.
5. Soltani M., 2024. Cytotoxic evaluation of Acanthophyllum glandulosum bung. ex boiss: Comparative analysis of anticancer activity on ags gastric cancer cells and human dermal fibroblasts. Journal of Biochemicals and Phytomedicine. 3(1), 41-45.
6. Mozaffarian V., 2012. A Dictionary of Iranian Plant Names. Tehran: Farhang Moaser; 1.
7. Zargari A., 1992. Medicinal Plants. Vol. 1. Tehran: Tehran University Publications, 2.
8. Avicenna I., 1987. The Canon of Medicine. Translated by Laleh Bakhtiar. Great Books of the Islamic World; 1.
9. Amin G., 2005. Popular Medicinal Plants of Iran. Tehran: Tehran University of Medical Sciences, 1.
10. Ghassemi Dehkordi N., 2008 Pharmacognosy and Medicinal Plants. Tehran: Tehran University Publications, 1.
11. Zargari A., 1996. Medicinal Plants. Vol. 4. Tehran: Tehran University Publications, 1.
12. Boskabady M.H., Shafei M.N., Saberi Z., Amini S., 2011. Pharmacological effects of Rosa damascena. Iranian Journal of Basic Medical Sciences. 14(4), 295-307. Available from: doi:10.22038/IJBMS.2011.5013.
13. Mikaili P., Mojaverrostami S., Moloudizargari M., Aghajanshakeri S., Sarahroodi S., 2013. Pharmacological and therapeutic effects of Lavandula angustifolia. Pharmaceutical Biology. 51(7), 860-867. Available from: doi:10.3109/13880209.2013.766270.
14. Houghton P.J., 1996. The scientific basis for the reputed activity of Valerian officinalis. Journal of Ethnopharmacology. 56(2),121-127. doi:10.1016/S0378-8741(97)00169-8.
15. Mahdavi R., Nikniaz L., Rafraf M., Jouyban A., 2017.Effects of Ziziphus jujuba on lipid profiles and blood pressure in hypercholesterolemic Iranian patients: A randomized controlled trial. Journal of Ethnopharmacology. 118(1), 59-63. doi:10.1016/j.jep.2008.03.014.
16. Mc Intyre A., 2005 Herbal treatment of children, Western and Ayurvedic Perspectives. Edinburgh: Elsevier; 1.
17. The Herb Society’s Complete Medicinal Herbal. A practical guide to medicinal herbs with remedies for common ailments. New York: Dorling Kindersley; 1993, pp: 47, 134, 174, 176.
18. Dinarello, C.A., 1996. Cytokines as endogenous pyrogens and mediators of fever. Journal of Infectious Diseases.179 (Supplement_2), S294-S304. doi:10.1086/513797.
19. Amiri M.S., Joharchi M.R., 2013. Ethnobotanical and ethnomedicinal studies on the traditional knowledge of wild medicinal plants in Torbat-e Jam district, Northeastern Iran. Journal of Ethnopharmacology. 145(3), 813-823. doi:10.1016/j.jep.2012.11.021.
20. Srivastava J.K., Shankar E., Gupta S., 2010. Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports. 3(6), 895-901. doi:10.3892/mmr.2010.377.
21. McKay D.L., Blumberg, J.B., 2006. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytotherapy Research. 20(8), 619-633. doi:10.1002/ptr.1936.
22. Stahl-Biskup E., Saez F., 2002. Thyme: The genus Thymus. CRC Press. doi:10.1201/9781482293187.
23. Barnes J., Anderson L.A., Phillipson, J.D., 2007. Herbal Medicines (3rd ed.). Pharmaceutical Press. doi:10.1002/9781119958550.ch12.
24. Blumenthal M., Goldberg A., Brinckmann J., 2000. Herbal Medicine: Expanded Commission E Monographs. American Botanical Council. doi:10.1016/S1060-3743(01)80024-6.
25. Boskabady M.H., Shafei M.N., Saberi Z., Amini S., 2011. Pharmacological effects of Rosa damascena. Iranian Journal of Basic Medical Sciences. 14(4), 295-307. doi:10.22038/IJBMS.2011.4997.
26. Cavanagh H.M., Wilkinson J.M., 2002. Biological activities of lavender essential oil. Phytotherapy Research. 16(4), 301-308. doi:10.1002/ptr.1103.
27. Houghton P.J., 1999. The scientific basis for the reputed activity of Valerian officinalis. Journal of Ethnopharmacology, 56(2), 121-127. doi:10.1016/S0378-8741(98)00178-8.
28. Mahdavi R., Nikniaz L., Rafraf M., Jouyban, A., 2007. Effects of Ziziphus jujuba on lipid profiles and blood pressure in hypercholesterolemic Iranian patients: A randomized controlled trial. Journal of Ethnopharmacology. 118(1), 59-63. doi:10.1016/ j.jep.2008.03.022.
29. Benedek B., Kopp B., Melzig, M.F., 2007. Achillea millefolium L. s.l. – Is the anti-inflammatory activity mediated by protease inhibition? Journal of Ethnopharmacology. 113(2), 312-317. doi:10.1016/ j.jep.2007.05.025.
30. Côté A., Haddad P.S., Angers P., Petit, A., 2009. Chemical composition and anti-inflammatory activity of Tilia europea inflorescences. Planta Medica, 75(1), 43-49. doi:10.1055/s-0028-1088364.
31. Barak V., Halperin T., Kalickman I., 2001. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. European Cytokine Network. 12(2), 290-296.
32. Canter P.H., Ernst E., 2004. Anthroposophical medicine: A systematic review of randomized clinical trials. Wiener Klinische Wochenschrift. 116(11-12), 426-433. doi:10.1007/BF03040461.
33. Harris J.C., Cottrell S.L., Plummer S., Lloyd, D., 2001. Antimicrobial properties of Allium sativum (garlic). Applied Microbiology and Biotechnology. 57(3), 282-286. doi:10.1007/s002530100722.
34. Saller R., 2011. Use of Herbal Medicines in Pediatric Practice: A Review. J Pediatr Pharmacol Ther. 6(2):131-139. doi: 10.5863/1551-6776-6.2.131.
35. Vickers A, 2006. Herbal Medicine for the Treatment of Fever in Children. Cochrane Database Syst Rev. (3). doi: 10.1002/14651858.CD004211.pub2
36. World Health Organization. Herbal Medicines. Available from: https://www.who.int/traditional-complementary-integrative-medicine/herbal-medicines/en/