The Effects of Eight Weeks Swimming Training on Interleukin- 17, Interleukin- 18 and Tumor Necrosis Factor-α in Streptozotocin Induced Diabetic Rats
محورهای موضوعی : Report of Health Care
Mahboobe Karbalayi
1
(
Department of Sport Physiology, Zabol Branch, Islamic Azad University, Zabol, Iran
)
Mehdi Noura
2
(
Department of Sport Physiology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
)
Mohsen Noura
3
(
Department of Sport Physiology, Zabol Branch, Islamic Azad University, Zabol, Iran
)
کلید واژه: Training, Diabetes, IL- 17, IL- 18, TNF- &alpha, ,
چکیده مقاله :
Introduction: Inflammation is a feature of the diabetes disease. The aim this study was to determine the effects of eight weeks swimming training on Interleukin- 17 (IL-17), Interleukin- 18 (IL-18) and tumor necrosis factor- α (TNF-α) in streptozotocin-induced diabetic rats. Methods: In this experimental study, 30 diabetic rats were accidentally divided into two equal groups of 15: swimming training and control. The rats in the swimming training group swam for eight weeks, three sessions per week; in the first two weeks for 10 minutes and six weeks later for 30 minutes. The control group rats had no sports activity. 24 hours after the last training session, the rats were sacrificed to measure the parameters in the study. The data were analyzed using SPSS version 19 and paired sample t-test (p≤0.05). Results: eight weeks of swimming training had no significant effect on reduction of IL-17 (p = 0.30), IL-18 (p = 0.41) and TNF-α (p = 0.81) in diabetic rats. Conclusion: it can be concluded that the present training has no significant effect on inflammatory factors in diabetic rats.
1. Salehi O R, Hoseini A. The Effects of endurance trainings on serum BDNF and insulin levels in streptozotocin- induced diabetic rats. Shefaye Khatam J. 2016; 5 (2): 52- 61.
2. Kim J –S, Lee YH, Kim J C, Ko Y H, Yoon C S, Yi HK. Effect of exercise training of different intensities on anti- inflamatory reaction in streptozotocin- induced diabetic rats. Biolsport. 2014; 31 (1): 73- 79.
3. Nikseresht M, Agha Alinejad H, Azarbayjani MA, Ebrahim K. Effects of nonlinear resistance and aerobic interval training on cytokines and insulin resistance in sedentary men who are obese. J Strength Cond Res. 2014; 28 (9): 2560- 2568.
4. Jafarzadeh A, Esmaeli Nadimi A, Nough H, Golshiri A, Nakhaei M, Dalir B, et al . Serum levels of interleukin (IL)- 17 in patients with acute myocardial infarction and unstable angina. RJMS. 2009; 16 (62): 99- 104.
5. Troseid M, Seljeflot I, Hjerkinn E, Arnesen H. Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome. Diabetes Care. 2009; 32: 486- 492.
6. Farajzadeh D, Karimi-Gharigh S, Dastmalchi S. Tumor necrosis factor-alpha and its inhibition strategies: review article. Tehran Univ Med Sci J. 2016; 75 (3): 159- 171.
7. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. PNAS. 1994; 91 (11): 4854- 4858.
8. Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and
type 2 diabetes. Trends Endocrinol Metab. 2000; 11 (6): 212- 217.
9. Hosseini SA, Nemati J, Ranjbar M, Edalatmanesh MA, Zar A. Hypoglycemic interactive effects of ginger extract and endurance training in diabetic rats. Horizon Med Sci J. 2016; 23 (4): 325- 330.
10. Ranjbar R, Habibi A, Abolfathi F, Nagafian N. The effect of aerobic interval training on IL-6 and IL-10 serum concentration in women with type II diabetes. AMUJ. 2016; 19 (7): 36- 45.
11. Rahimi A, Moghaddasi M, EdalatManesh MA. The effect of eight weeks of resistance training on the level of interleukin-17 and cortisol in MS patients. RSSQ. 2015; 7 (20): 37- 52.
12. Pedersen R, Hoffman G. Effect of acute moderate and strenuous exercise bouts on IL- 17 production and inflammatory response in trained rats. J Appl Physiol. 2001; 92: 2547- 2553.
13. Kabir B, Taghian F, Ghatre-Samani K. Effect of aerobic training on levels of interleukin- 18 and C-reactive protein in elderly men. J Shahrekord Univ Med Sci. 2014; 16 (3): 8- 15.
14. Molanouri Shamsi M, Alinejad H, Amani Shalamzari S, Aghayari A, Asghari Jafarabadi M, Talebi Badrabadi K. Anti-Inflammatory effects of a bout of circuit resistance exercise with moderate intensity in inactive obese males. JSSU. 2011; 19 (5): 598- 609.
15. Agha-Alinejad H, Saei M, Mahdavi M, Amani Shalamzari S, Kazemi A, Pirayesh M. The effect of 6 weeks endurance training on the levels of some cytokines in tumor microenvironment in breast cancer bearing mice. JSB. 2015; 6 (4): 483- 496.
16. Jahangiri RJ, Farzanegi P, Habibian MH. The Effect of aerobic training and arbotin on cardiac nitric oxide, tumor necrosis factor alpha, and vascular endothelial growth factor in male diabetic rats. Qom Univ Med Sci J. 2016; 11 (5): 53- 62.
17. Nayanatara AK, Nagaraja HS, Anupama BK. The effect of repeated swimming stress on organ weights and lipid peroxidation in rats. TJPS. 2005; 18 (1): 3- 9.
18. Badiakhar H, Mogharnasi M, Kazemi A, Papoli Baravati SA. The effect of circular resistance training on serum level of IL-17 and immunoglobulins M, A, G in obese handicapped men. Qom Univ Med Sci J. 2016; 11 (9): 94- 103.
19. Satarifard S, Gaeini AA, Choobineh C, Shafiei Neek L, Azami A, Adibfard E,et al. Changes of salivary IgA of athletes after a single bout of exercise in cold, warm and natural environments. HMJ. 2013; 17 (3): 229- 239.
20. Alizadeh H, Daryanoosh F, Moatari M, Hoseinzadeh K. Effects of aerobic and anaerobic training programs together with omega-3 supplement on interleukin-17 and CRP plasma levels in male mice. MJIRI. 2015; 29: 236- 240.
21. Duzova H, Kardakoc Y, Hanifi MT, Yilmaz ZD, Kilinic E. Effects of acute moderate and strenuous exercise bouts on IL-17 production and inflammatory response in trained rats. JSSM. 2009; 8: 219- 224.
22. Dong C, Chang S H. A novel heterodimeric cytokine consisting of IL-17 and IL-17 regulates inflammatory responses. Cell Res. 2007; 17: 435- 440.
23. Amani Shalamzari S, Agha Alinejad H, Gharakhanlou R, Molanouri Shamsi M, Talebi Badrabadi K. The effect of body composition and physical activity on basal levels of insulin, glucose, IL-18, IL-6, CRP and their relationship with insulin resistance. IJEM. 2009; 11 (6): 699- 706.
24. Kouhi F, Moradi F, Absazadegan M. Effect of resistance training on serum interleukin-18 and C-reactive protein in obese men. J Gorgan Univ Med Sci. 2014; 16 (1): 1- 8.
25. Zakavi I, Sharifi M, Panahizadeh M, Valipour A. Effect of eight weeks roping interleukin- 18 and C- reactive protein the in overweight and obese adolescents. IJEM. 2014; 6 (1): 37- 48.
26. Daryanoosh F, Jafari H, Rahimi E, Mehrbani D, Soltani F. The effect of eight week interval acute training on plasma visfatin, TNF- α and IL-6 in rats: a brief report. Tehran Univ Med J. 2013; 71 (9): 603- 608.
27. Taheri Kalani A, Nikseresht M. The effect of 10 weeks resistance and aerobic training on inflammatory cytokines in sedentary overweight men. SJIMU. 2015; 23 (5): 17- 26.
28. Vosoughi V, Moradi F, Aghaalinejad H, Peeri M. Effect of strength training on CRP, TNF- α, muscular strength, and cardio- respiratory function in inactive adolescent girls. JRUMS. 2015; 14 (2): 85- 98.
29. Abdollahpour A, Khosravi N, Eskandari Z, Haghighat S. Effect of six months of aerobic exercise on plasma interleukin- 6 and tumor necrosis factor alpha as breast cancer risk factors in postmenopausal women: a randomized controlled trial. Iran Red Crescent Med J. 2016; 19 (1): e27842.
30. Ryan AS, Nicklas BJ. Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women. Diabetes Care. 2004; 27: 1699- 1705.
31. Banitalebi E, Razavi T, Norian M, Bagheri L. The effect of combined aerobic exercise training and green tea extract on serum TNF- α and IL- 6 levels in obese women with type 2 diabetes. Daneshvar Med Sci J. 2016; 23 (123): 11- 20.
32. Kazemi A, Rahmati M, Fariabi M, Taherabadi SJ. Effect of eight weeks high intensity interval training (HIT) on body weight and serum levels of TNF- α, insulin and lipid profile in obese children. RJMS. 2016; 22 (139): 1- 7.
