Effect of Aerobic Training with Ginger Supplement on Plasma Levels of Visfatin and Lipid Profile in Middle-aged Obese Men

محورهای موضوعی : Report of Health Care

Mehri Gholipoor ¹ , Mohammad Karimi ² , Saeed Keshavarz ³

1 - Department of Physical Education and Sport Sciences, Qom University of Technology, Qom, Iran
2 - Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
3 - Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran

تاریخ دریافت : 1397/08/27 تاریخ پذیرش : 1398/10/01 تاریخ انتشار : 1398/09/10

کلید واژه: Obesity, Aerobic Training, Ginger, Visfatin,

چکیده مقاله :

Introduction: The aim of this research was to study the effect of eight weeks of aerobic training with ginger supplementation on plasma visfatin and lipid profile in obese men. Methods: Forty volunteer middle-aged obese men were divided randomly into four equal groups (n=10) including; placebo, ginger supplement, aerobic training and aerobic training with ginger supplement. Aerobic training consisted of eight weeks, three sessions per week and intensity of 55-65 percentage of maximum heart rate. Ginger supplementation consisted of 3 gr ginger consumption as capsule, three times before each meal for eight weeks. Changes of plasma levels of visfatin and lipid profile were assayed before and after eight weeks. Data were analyzed using one-way ANOVA test and Tucky’s post-hoc comparison (p<0.05). Results: There was significant difference between groups in plasma levels of visfatin (p=0.03), VLDL (p=0.01) and TG (p=0.03). The observed difference was related to placebo and aerobic training with ginger supplement groups. Conclusion: It seems that eight weeks of aerobic training with ginger supplementation may improve some cardiovascular risk factors in middle-agesd obese men.

منابع و مأخذ:

1. Sorani M, Jalali Dehkordi KH, Jalali Dehkordi A. Effect of 12 weeks aerobic training with ginger consumption on IL-18 and CRP in obese men. Rep Health Care. 2016; 2 (4): 1- 9.


2. Karbaschian Z, Hosseinzadeh-Attar MJ, Giahi L, Golpaie A, Masoudkabir F, Talebpour M, et al. Portal and systemic levels of visfatin in morbidly obese subjects undergoing bariatric surgery.Endocrine J. 2013; 44 (1): 114- 118.


3. Mohammadi Damieh A, Khajelandi A, Rostami A, Asadi E. The effects of eight weeks of resistance versus endurance training on plasma visfatin level in middle- aged men. Armaghane danesh J. 2010; 15 (3): 233- 242.


4. Hossein Nejad A, Mirzaei K, Hosseinzadeh MJ, Jafari N, Najm Afshar A, Rahmani M, et al. The effect of visofatin genotype on the need for oral glucose control drugs in patients with typeII diabetes. Iranian J Diabetes Metab. 2009; 8 (3): 227- 236.


5. Romacho T, Villalobos LA, Cercas E, Carraro R, Sánchez-Ferrer CF. Visfatin as a novel mediator released by inflamed human endothelial cells. PLoS One. 2013; 8 (10): e78283.


6. Romacho T, Azcutia V, Vázquez-Bella M, Matesanz N, Cercas E. Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Diabetologia. 2009; 52: 2455- 2463.


7. Saddi-Rosa P, Oliveira CSV, Giuffrida FMA, Reis AF. Visfatin, glucose metabolism and vascular disease: a review of evidence. Diabetol Metab Synd. 2010; 2 (21): 1- 6.


8. Frydeland-Larson L. Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise. AM J Physiol Endocrinol Metab. 2006; 292: 24- 31.


9. Ghanbari Niaki A, Fathi R, Shahandeh F, Yazdani M, Hajizadeh A. The effect of endurance training and Pistacia atlantica (bene) extraction on resting plasma visfatin and lipids levels in female rats. Daneshvar Med J. 2011; 94 (1): 1- 11.


10. Haider DG, Mittermayer F, Schaller G, Artwohl M, Baumgartner-Parzer SM, Gerhard Prager G. Free fatty acids normalize a rosiglitazone-induced visfatin release. Am J Physiol Endocrinol Metab. 2006; 291 (5): 885- 890.


11. Eatemady-Boroujeni A, Kargarfard M, Mojtahedi H, Rouzbehani R, Dastbarhagh H. Comparison of the effects of 8- weeks aerobic training and resistance training on lipid profile in patients with diabetes type 2. J Isfahan Med Sch. 2014; 32 (282): 524- 533.


12. Matsuda A, Wang Z, Takahashi S, Tokuda T, Miura N, Hasegawa J. Upregulation of mRNA of retinoid binding protein and fatty acid binding protein by cholesterol enriched-diet and effect of ginger on lipid metabolism. Life Sci. 2009; 19 (84): 903- 907.


13. Pongrojpaw D, Somprasit C, Chanthasenanont A. A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy.J Med Assoc Thai. 2007; 90 (9): 1703- 1709.


14. Eizadi M, Karimy M, Kohandel M, Doaly H. Effect of aerobic exercise on serum leptin response and insulin resistance of patients with type 2 diabetes. J Qazvin Univ Med Sci. 2013; 16 (4): 33- 39.


15. Rawasi AA, Aminian Razavi T, Gaieni AA, Hamedinia MR, Haghighi AH. The effect of endurance training on pro-inflammatory cytokines and insulin resistance in obese men. Movement. 2006; 28 (1): 31- 49.


16. Mahluji S, Ostadrahimi A, Mobasseri M, Ebrahimzade Attari V, Payahoo L. Anti-inflammatory effects of Zingiber officinale in type 2 diabetic patients. Adv Pharm Bull. 2013; 3 (2): 273- 276.


17. Jurimae J, Ramson R, Maestu J, Purge P, Jurimae T, Arciero PJ et al. Plasma visfatin and ghrelin response to prolonged sculling in competitive male rowers. Med Sci Sports Exer. 2009; 41: 137- 143.


18. Jia SH, Li Y, Parodo J, Kapus A, Fan L, Rotstein OD et al. Pre–B cell colony–enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest. 2004; 113 (9): 1318– 1327.


19. Dogru T, Sonmez A, Tasci I, Bozoglu E. Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance. Diabetes Res Clin Pract. 2007; 76 (1): 24- 29.


20. Kendal CE, Bryant-Greenwood GD. Pre-B-cell colony-enhancing factor (PBEF/Visfatin) gene expression is modulated by NF-κB and AP-1 in human amniotic epithelial cells. Placenta. 2007; 28 (4): 305- 314.


21. Kralisch S, Klein J, Lossner U, Bluher M, Paschke R, Stumvoll M. Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes. J Endocrinol. 2005; 1: 185- 193.


22. Aiping L, Wenhe C, Kelly H. Effects of visfatin gene polymorphism RS4730153 on exercise-induced weight loss of obese children and adolescents of han chinese. Int J Biol. 2013; 9 (1): 16- 21.


23. Alizadeh-Navaei R, Roozbeh F, Saravi M, Pouramir M, Jalali F, Moghadamnia AA. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J. 2008; 29 (9): 1280- 1284.


24. Attarzadeh Hoseini SR, Rahimiyan Mashhad Z. Comparison the effect of aerobic training and diet on Body Composition and Metabolic Syndrome Indexes in overweight and obese women. Int Shomal Sports Sci Conf. 2012.


25. Marques E, Carvalho J, Soares JMC, Marques F Mota J. Effects of resistance and multicomponent exercise on lipid profiles of older women. Maturitas. 2009; 63: 84- 88.


26. Askari R, Ravasi AA, Gaeini AA, Hedayati M, Hamedinia MR. The effect of combined exercise training on some adipokines and insulin sensitivity index in overweight females. J Sport Biomotor Sci. 2012; 5 (1): 25- 37.


27. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, et al. Effects of the amount and intensity of exercise on plasma lipoproteins. New England J Med. 2002; 347 (19): 1483- 1492.


28. Saremi A, Shavandi N, Bayat N. The effect of aerobic training on ghrelin and leptin serum levels and sleep quality in obese and overweight men. Arak Med Univ J. 2012; 15 (60): 52- 60.