The Relationship between Estrogen and Lipid Profile in Follicular Phase of Active Women
محورهای موضوعی : Report of Health Care
Shirin Zilaei Bouri
1
,
Leila Mansori
2
1 - Department of physical education & sport sciences, Masjed-Soleiman Branch, Islamic Azad University (I.A.U), Masjed-Soleiman, Iran.
2 - Department of physical education & sport sciences, Masjed-Soleiman Branch, Islamic Azad University (I.A.U), Masjed-Soleiman, Iran.
کلید واژه: Lipid Profile, Menstrual Cycle, Estrogen,
چکیده مقاله :
Introduction: Estrogen is the basis of pregnancy and is involved in many physiological activities. Regarding the effects of exercise on lipid profile and estrogen, the aim of this study was to investigate the relationship between estrogen and lipid levels in active women. Methods: From among female students of Islamic Azad University of Masjed-Soleiman, after examining the conditions of inclusion and signing consent form, 38 inactive women (age: 26.1 ± 6.27 y; BMI: 24.2 ± 2.4 kg.m-2) and 31 active women (at least 150 min activity per week; age: 27.68 ± 5.72y, BMI: 22.3 ± 65.64 kg.m-2) participated in study. In the late folicular phase, 3-cc blood was taken from the subjects in the fasting state. HDL, LDL, TG, cholesterol and estrogen (17 Beta-estradiol) were measured during four months. Pearson correlation and sample t-test for statistical analysis was used. The significance level was p <0.05. Results: The results showed in active women there was a significant inverse relationship between estrogen and cholesterol (P = 0.01) and TG (P = 0.02). Comparing the groups, the levels of cholesterol (P = 0.0001), LDL (P = 0.0001) and TG (P = 0.01) in active woman were significantly lower than inactive women. Conclusion: The results of our study showed that measurement of estrogen and blood lipids in different times of menstrual cycle was different in active and inactive women. Therefore, regarding the enormous effects of endogenous estrogen on health, it is recommended that women maintain a good level of activity per week in order to benefit from its health benefits.
1. Haskell WL, Lee I-M, Pate RR, Powell KE, Blair SN, Franklin BA, et al. Physical activity and public health: updated recommendation for adults from the american college of sports medicine and the american heart association. Circulation. 2007; 116 (9): 1081- 1089.
2. Bu Gurbuz UC, TaFatma AD. The effects of an 8-week walking program on serum lipids, circulation matrix metalloproteinasese and tissue inhibitor of metalloproteinase-1 in post-menopausal women. Turk J Biochem. 2009; 33 (4): 154- 216.
3. Zachariah G, Alex AG. Exercise for prevention of cardiovascular disease: Evidence-based recommendations. J Clin Prev Cardiol. 2017; 6 (3): 109- 118.
4. Lin Y-Y, Lee S-D. Cardiovascular benefits of exercise training in postmenopausal hypertension. Int J Mol Sci. 2018; 19 (9): 2523- 2529.
5. Zekri R, Jafari A, Dehghan G. The concurrent effect of one bout aerobic exercise and short-term garlic supplementation on the lipids profile in male non-athletes. J Shahrekord Univ Med Sci. 2012; 14 (5): 34- 41.
6. Mumford SL, Schisterman EF, Siega-Riz AM, Browne RW, Gaskins AJ, Trevisan M, et al. A longitudinal study of serum lipoproteins in relation to endogenous reproductive hormones during the menstrual cycle: findings from the BioCycle study. J Clin Endocrinol Metab. 2010; 95 (9): E80- E85.
7. El Khoudary SR, Brooks MM, Thurston RC, Matthews KA. Lipoprotein subclasses and endogenous sex hormones in women at midlife. J Lipid Res. 2014; 55 (7): 1498- 1504.
8. Hajighasem A, Farzanegi P, Mazaheri Z. Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis and lipid profile in the liver tissue of rats with nonalcoholic fatty liver disease. Rep Health Care. 2018; 4 (4): 21- 29.
9. Fathei M. The effect of aerobic exercise on homocysteine, C- reactive protein and lipid profile in active and inactive men. Rep Health Care. 2018; 4 (4): 38- 46.
10. Aghaei F, Shadmehri S, Pirbeyg Darvishvand Z. The effect of aerobic training with green coffee on body composition and lipid profile in overweight women. Rep Health Care. 2018; 4 (2): 38- 46.
11. Lamon-fava S, Fisher EC, Nelson ME, Evans WJ, Millar JS, Ordovas JM, et al. Effect of exercise and menstrual cycle status on plasma lipids, low density lipoprotein particle size, and apolipoproteins. J Clin Endocrinol Metab. 1989; 68 (1): 17- 21.
12. Health UDo, Services H. Be active, healthy, and happy. MO Leavitt (Ed). 2008.
13. Wall PML, Choudhury N, Gerbrandy EA, Truswell AS. Increase of high-density lipoprotein cholesterol at ovulation in healthy women. Atherosclerosis. 1994; 105 (2): 171- 178.
14. Lamon-Fava S, Barnett JB, Woods MN, McCormack C, McNamara JR, Schaefer EJ, et al. Differences in serum sex hormone and plasma lipid levels in caucasian and african- american premenopausal women. J Clin Endocrinol Metab. 2005; 90 (8): 4516- 4520.
15. Barnett JB, Woods MN, Lamon-Fava S, Schaefer EJ, McNamara JR, Spiegelman D, et al. Plasma lipid and lipoprotein levels during the follicular and luteal phases of the menstrual cycle. J Clin Endocrinol Metab. 2004; 89 (2): 776- 782.
16. Lin X, Zhang X, Guo J, Roberts CK, McKenzie S, Wu WC, et al. Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: a systematic review and meta‐analysis of randomized controlled trials. J Am Heart Assoc. 2015; 4 (7): e002014.
17. Mumford SL, Dasharathy S, Pollack AZ. Variations in lipid levels according to menstrual cycle phase: clinical implications. Clin Lipidol. 2011; 6 (2): 225- 234.
18. Reed RG, Kris-Etherton P, Stewart PW, Pearson TA. Variation of lipids and lipoproteins in premenopausal women compared with men and postmenopausal women. Metab Clin Exp. 2000; 49 (9): 1101- 1105.
19. Lebrun CM, Joyce SM, Constantini NW. Effects of female reproductive hormones on sports performance. 2nd ed. Constantini, N and Hackney, A ,Editors. Endocrinology of Physical Activity and Sport: Springer; 2013; 281- 322.
20. Meyer M, Barton M. Estrogens and coronary artery disease: new clinical perspectives. Adv Pharmacol. 2016; 77: 307- 360.
21. Lopez D, McLean MP. Estrogen regulation of the scavenger receptor class B gene: Anti-atherogenic or steroidogenic, is there a priority?. Mol Cell Endocrinol. 2006; 247 (1-2): 22- 33.
22. Fukata Y, Yu X, Imachi H, Nishiuchi T, Lyu J, Seo K, et al. 17 β-Estradiol regulates scavenger receptor class BI gene expression via protein kinase C in vascular endothelial cells. Endocrine. 2014; 46 (3): 644- 650.
23. Palmisano BT, Zhu L, Stafford JM. Role of estrogens in the regulation of liver lipid metabolism. In: Mauvais-Jarvis, Franck, editor. Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Seattle: Springer; 2017; 227- 256.
24. Knopp RH, Paramsothy P, Retzlaff BM, Fish B, Walden C, Dowdy A, et al. Sex differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular disease. Curr Cardiol Rep. 2006; 8 (6): 452- 459.
25. Abdel-Barry J, Flafl M, Al-Namaa L, Hassan N. Lipoprotein changes in women taking low-dose combined oral contraceptive pills: a cross-sectional study in Basra, Iraq/Modification des taux de lipoproteines chez les femmes sous contraceptifs oraux associes faiblement doses: une etude transversale realisee a Bassora (Iraq). East Mediterr Health J. 2011; 17 (9): 684.
26. Howard BV, Rossouw JE. Estrogens and cardiovascular disease risk revisited: the Women’s Health Initiative. Curr Opin Lipidol. 2013; 24 (6): 493- 501.
27. Earnest CP, Artero EG, Sui X, Lee D-c, Church TS, Blair SN, editors. Maximal estimated cardiorespiratory fitness, cardiometabolic risk factors, and metabolic syndrome in the aerobics center longitudinal study. Mayo Clin Proc. 2013; 88 (3): 259- 270.
28. Calabresi L, Franceschini G. Lecithin: cholesterol acyltransferase, high-density lipoproteins, and atheroprotection in humans. Trends Cardiovasc Med. 2010; 20 (2): 50- 53.
29. Riedl I, Yoshioka M, Nishida Y, Tobina T, Paradis R, Shono N, et al. Regulation of skeletal muscle transcriptome in elderly men after 6 weeks of endurance training at lactate threshold intensity. Exp Gerontol. 2010; 45 (11): 896- 903.
30. Harrison M, Moyna NM, Zderic TW, O’Gorman DJ, McCaffrey N, Carson BP, et al. Lipoprotein particle distribution and skeletal muscle lipoprotein lipase activity after acute exercise. Lipids Health Dis. 2012; 11 (1): 64- 72.
