Novel Study of the Effect of Spexin Hormone on Heart Attack Disease
محورهای موضوعی :
Assim Yousif Al- Farag
1
,
Zena A.M. AL-Jawadi
2
1 - Department of Chemistry, College of Science, University of Mosul, Iraq
2 - Department of Chemistry, College of Science, University of Mosul, Iraq
کلید واژه: Spexin Hormone, Heart Attack Disease, Cholesterol, Lipid Profile ,
چکیده مقاله :
Spexin hormone (SPX) is a new peptide that has multiple activities in adipose tissue, including energy balance regulation and fatty acid uptakend and related metabolic diseases its physiological significance in the cardiovascular system remains mostly undefined. The aim of the current study was to determine the potential role of Circulating levels of SPX in heart attack illness and potential role in preventing through the measurement spexin hormone, lipid profile, atherogenic risk factor, and body mass index in the serum of 91 heart attack patients and 91 control groups. The age ranges were thirty to seventy-eight, and the study found a substantial drop in spexin hormone and high-density lipoprotein cholesterol levels in comparison with the group in control (P≤0.001). Additionally, all of the following were significantly higher than in the healthy group: body mass index, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, total cholesterol, and atherogenic risk factor at (P≤0.001). The study indicated a substantial relationship between spexin hormone, total cholesterol, and low-density lipoprotein with a high body mass index. As a result, the study proved that a decrease in spexin hormone is a novel indicator of an increase in heart attack disease and has the potential to be employed as an early diagnostic marker in heart attack patients.
Spexin hormone (SPX) is a new peptide that has multiple activities in adipose tissue, including energy balance regulation and fatty acid uptakend and related metabolic diseases its physiological significance in the cardiovascular system remains mostly undefined. The aim of the current study was to determine the potential role of Circulating levels of SPX in heart attack illness and potential role in preventing through the measurement spexin hormone, lipid profile, atherogenic risk factor, and body mass index in the serum of 91 heart attack patients and 91 control groups. The age ranges were thirty to seventy-eight, and the study found a substantial drop in spexin hormone and high-density lipoprotein cholesterol levels in comparison with the group in control (P≤0.001). Additionally, all of the following were significantly higher than in the healthy group: body mass index, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, total cholesterol, and atherogenic risk factor at (P≤0.001). The study indicated a substantial relationship between spexin hormone, total cholesterol, and low-density lipoprotein with a high body mass index. As a result, the study proved that a decrease in spexin hormone is a novel indicator of an increase in heart attack disease and has the potential to be employed as an early diagnostic marker in heart attack patients.
1. Jiaquan Xu., Sherry Murphy L., Kenneth Kochanek D., Elizabeth A., 2015. Mortality in the United States, 2015 Key Findings. http://www.cdc.gov/nchs/data/databriefs/.
2. Akbartabar M., Kiani F., Sayehmiri F., Sayehmiri K., Mohsenzadeh Y., Ostovar R., Angha P., Mohsenzadeh Y., 2018. Prevalence of Hypercholesterolemia, High LDL, and Low HDL in Iran: A Systematic Review and Meta-Analysis.” Iran J Med Sci September. 43(5):449-465.
3. Zhao X., Dongying W., Lijie Q., 2021. “ipid Profile and Prognosis in Patients with Coronary Heart Disease: A Meta-Analysis of Prospective Cohort Studies. BMC Cardiovascular Disorders. 21(1). https://doi.org/10.1186/s12872-020-01835-0.
4. Fang J., Cecily L., Carma Ayala., Erika O., Fleetwood L., 2019. Awareness of Heart Attack Symptoms and Response Among Adults — United States, 2008, 2014, and 2017. MMWR. Morbidity and Mortality Weekly Report. 68 (5), 101–6. https://doi.org/10. 15585/mmwr.mm6805a2.
5.Türkel, İ., Gülsün M., Burak Y., 2022. Impact of Spexin on Metabolic Diseases and Inflammation: An Updated Minireview.” Experimental Biology and Medicine. SAGE Publications Inc. https://doi.org/10.1177/15353702211072443.
6. Liu Y., Li S., Linqun Zh., Mengqi S., He L., Ying W., Dan L., 2020. Spexin Protects Cardiomyocytes from Hypoxia-Induced Metabolic and Mitochondrial Dysfunction.” Naunyn-Schmiedeberg’s Archives of Pharmacology. 393(1), 25–33. https://doi.org/10.1007/ s00210-019-01708-0.
7. Lv Shuang Y., Yu Chen Zh., Xiao Mei Zh., Wei Dong Ch., Yan Dong W., 2019. Emerging Roles of NPQ/Spexin in Physiology and Pathology.” Frontiers in Pharmacology. Frontiers Media S.A. https://doi.org /10.3389/fphar.2019.00457.
8. Kumar S., Robert T.M., Stephen D.A., Balagopal P.B., 2021. Novel Insights on the Role of Spexin as a Biomarker of Obesity and Related Cardiometabolic Disease. International Journal of Obesity. 45(10), 2169–78. https://doi.org/10.1038/s41366-021-00906-2.
9. Çiftçi Y., Mehtap G., Evrim G., Yilmaz M., Selda T., Metin A., Mehmet Cagri G., Mehmet Ali K., 2023. Spexin Level In Acute Myocardial Infarction In The Emergency Department” Journal of Medical Biochemistry. 42(3), 407–11. https://doi.org/ 10.5937/jomb0-39485.
10. Kirkpatrick L., Feeney B.C., 2012. A Simple Guide to IBM SPSS Statistics for Version 18.0 and 19.0 11th Edn., Wadsworth Cengage Learning, Belmont. ISBN-10:1111352550. pp.115.
11. Lin Cheng Y., Tao Huang., Ling Zh., Linda L.D.Zh., Wai Ching L., Bao Min F., Zhao Xiang B., 2018. Circulating Spexin Levels Negatively Correlate with Age, BMI, Fasting Glucose, and Triglycerides in Healthy Adult Women. Journal of the Endocrine Society. 2(5), 409–19. https://doi.org/10.1210/js.2018-00020.
12. Vaghef-Mehrabany E., Maleki V., Pourmoradian S., Fathifar Z., Ostadrahimi A., 2020. Spexin Status in Relation to Obesity and Its Related Comorbidities: A Systematic Review. Journal of Diabetes and Metabolic Disorders. Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s40200-020-00636-8.
13. Bielecka-Dabrowa A., Breno G., Tsuyoshi S., Maciej B., Stephan von H., 2019. Subclinical Hypothyroidism and the Development of Heart Failure: An Overview of Risk and Effects on Cardiac Function. Clinical Research in Cardiology 108(3), 225–33. https://doi.org/10. 1007/s00392-018-1340-1.
14. Gu L., Yuhang M., Mingyu G., Ying Zh., Shuai Y., Na L., Yufan W., 2015. Spexin Peptide Is Expressed in Human Endocrine and Epithelial Tissues and Reduced after Glucose Load in Type 2 Diabetes. Peptides. 71, 232–39. https://doi.org/10.1016/j.peptides.2015.07.018.
15. Walewski, José L., Fengxia G., Harrison Lobdell I.V., Nancy L., Gary J. S., Joseph R.V., Afons Pomp, Gregory D., Paul D.B., 2014. Spexin Is a Novel Human Peptide That Reduces Adipocyte Uptake of Long Chain Fatty Acids and Causes Weight Loss in Rodents with Diet-Induced Obesity. Obesity. 22(7), 1643–52. https://doi.org/10.1002/oby.20725.
16. Hedayatnia M., Asadi Z., Zare-Feyzabadi R., Yaghooti-Khorasani M., Ghazizadeh H., Ghaffarian-Zirak R., Nosrati-Tirkani A., 2020. Dyslipidemia and Cardiovascular Disease Risk among the MASHAD Study Population.” Lipids in Health and Disease 19(1). https://doi.org/10.1186/s12944-020-01204-y.
17. Pandey A., Michael L., Liviu K., Colby A., Bruce M.P., Charles B. E., Norrina B. Al., 2017. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure.” Journal of the American College of Cardiology. 69(9), 1129–42. https://doi.org/10.1016/j.jacc.2016.11.081.
18. Salah Nouran Y., Dina Abu Z., Rania N S., Reham F.F., Mona A.A., Eman A., Azza O., Yasmin G.G., 2022. Circulating Spexins in Children with Obesity: Relation to Cardiometabolic Risk. European Journal of Clinical Nutrition. 76 (1), 119–25. https://doi.org/10.1038 /s41430-021-00912-7.
