Review On Suspension & Nanosuspension
محورهای موضوعی : میکروبیولوژیChetan Borase 1 , Amol Jagdale 2 , Monika Sonawane 3 , Akshay Katkale 4 , ROSHAN LANDGE 5 , Shubham kothawade 6
1 - MVP college of Pharmacy nashik
2 - NDMVP SAMAJ COLLEGE OF PHARMACY NASHIK
3 - NDMVP COLLEGE OF PHARMACY
4 - NDMVP SAMAJ COLLEGE OF PHARMACY NASHIK
5 - NDMVP COLLEGE OF PHARMACYNASHIK
6 - NDMVP SAMAJ COLLEGE OF PHARMACY ,NASHIK
کلید واژه: Suspensions, Suspending agents, Stability, Dissolution, Nanosuspension,
چکیده مقاله :
Pharmaceutical Suspension is a coarse dispersion of insoluble solid particles in a liquid medium. The particle diameter of the suspension is usually greater than 0.5 μm. However, establishing sharp boundaries between suspensions and dispersions with finer particles is difficult and impractical. Suspensions are an important class of pharmaceutical dosage forms. Advantages of suspension formulations include effective administration of hydrophobic drugs; refusal to use co-solvents; It masks the unpleasant taste of some ingredients. ensuring resistance to degradation of drugs due to hydrolysis, oxidation or microbial activity; It can be easily swallowed by young and elderly patients. Effective intramuscular depot therapy. In addition, relatively higher drug concentrations may be included in suspension products compared to solution formulations. This review provides an overview of various aspects of suspensions, such as classification of suspensions, suspension theory, various suspending agents, aspects of suspension formulations, packaging of suspensions, evaluation of suspensions, stability of suspensions, and recent research in progress. pendant. Solubility is a decisive factor in the effectiveness of a drug regardless of the route of administration. Most of the recently discovered drugs are insoluble in water and have low bioavailability, so development has failed. These so-called "Brickellia" candidates can now be formulated and delivered as nanosuspensions. Nanosuspension technology solves the problem of drugs that are poorly soluble in water and have low bioavailability. Nanosuspension technology can be used to improve drug stability and bioavailability. The preparation of nanosuspension is simple and applicable to all water-insoluble drugs. Nanosuspensions are prepared using wet mills, high pressure homogenizers, emulsion and solvent evaporation, melt emulsification, and supercritical fluid methods. Nanosuspensions can be prepared using stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmagents and cryoprotectants
Pharmaceutical Suspension is a coarse dispersion of insoluble solid particles in a liquid medium. The particle diameter of the suspension is usually greater than 0.5 μm. However, establishing sharp boundaries between suspensions and dispersions with finer particles is difficult and impractical. Suspensions are an important class of pharmaceutical dosage forms. Advantages of suspension formulations include effective administration of hydrophobic drugs; refusal to use co-solvents; It masks the unpleasant taste of some ingredients. ensuring resistance to degradation of drugs due to hydrolysis, oxidation or microbial activity; It can be easily swallowed by young and elderly patients. Effective intramuscular depot therapy. In addition, relatively higher drug concentrations may be included in suspension products compared to solution formulations. This review provides an overview of various aspects of suspensions, such as classification of suspensions, suspension theory, various suspending agents, aspects of suspension formulations, packaging of suspensions, evaluation of suspensions, stability of suspensions, and recent research in progress. pendant. Solubility is a decisive factor in the effectiveness of a drug regardless of the route of administration. Most of the recently discovered drugs are insoluble in water and have low bioavailability, so development has failed. These so-called "Brickellia" candidates can now be formulated and delivered as nanosuspensions. Nanosuspension technology solves the problem of drugs that are poorly soluble in water and have low bioavailability. Nanosuspension technology can be used to improve drug stability and bioavailability. The preparation of nanosuspension is simple and applicable to all water-insoluble drugs. Nanosuspensions are prepared using wet mills, high pressure homogenizers, emulsion and solvent evaporation, melt emulsification, and supercritical fluid methods. Nanosuspensions can be prepared using stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmagents and cryoprotectants
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