تأثیر یک دوره تمرین هوازی-مقاومتی بر بیان ژن گیرنده‌ی فعال‌کننده پرولیفراسیون پروگسیزوم گاما بیماران بای‌پس عروق کرونری

محورهای موضوعی : فصلنامه زیست شناسی جانوری

امین زاهدی انارکی ¹ (گروه تربیت ‌بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران)
رامبد خواجه ای ² (گروه تربیت ‌بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران)
امیر رشید لمیر ³ (گروه بیوشیمی و متابولیسم ورزشی، دانشکده علوم ورزشی, دانشگاه فردوسی مشهد، مشهد، ایران)
امنه برجسته یزدی ⁴ (گروه تربیت ‌بدنی و علوم ورزشی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران)

تاریخ دریافت : 1399/11/17 تاریخ پذیرش : 1400/01/15 تاریخ انتشار : 1400/09/01

کلید واژه: تمرینات هوازی, تمرینات مقاومتی, CABG, PPAR,

چکیده مقاله :

گیرنده های فعال کننده ی پرولیفراسیون پروگسیزوم گاما فاکتوری یک عامل رونویسی فعال‌شده به وسیله لیگاند می باشد که نقش مهمی در متابولیسم لیپیدها دارد. هدف از پژوهش حاضر اثر هشت هفته تمرینات هوازی- مقاومتی بر بیان ژن گیرنده ی فعال کننده پرولیفراسیون پروگسیزوم گاما در بیماران بای پس عروق گرونری بود. روش پژوهش حاضرنیمه تجربی و با طرح پیش آزمون-پس آزمون بود. جامعه آماری کلیه بیماران بای پس عروق کرونری شهر مشهد بودند.در مطالعه حاضر نمونه پژوهشی شامل 26 مرد میان‌سال با دامنه سنی 75/3 ± 73/56 (سال)، قد 03/0 ± 58/1 (متر)، وزن 54/5 ± 11/68 (کیلوگرم)، شاخص توده بدن 47/2 ± 18/27 (کیلوگرم/مترمربع) و سابقه ی بیماری 75/8 ± 20/25 (ماه) پس از عمل بای پس عروق کرونر تشکیل‌شده بود. بر اساس معیارهای ورود به تحقیق، در دو گروه در تجربی (14) و کنترل (12) قرار گرفتند. داده ها با استفاده از آزمون تی مستقل وتی همبسته در سطح معنی داری 05/0≥p و نرم افزار SPSS نسخه 21تحلیل شدند. نتایج نشان داد که هشت هفته تمرینات هوازی-مقاومتی سبب افزایش بیان ژن PPAR در گروه تمرین ترکیبی نسبت به گروه کنترل شد (001/0=p ). همچنین نتایج آماری آزمون تی همبسته نشان داد که افزایش بیان ژن PPAR در گروه تمرین ترکیبی افزایش معناداری در پس‌آزمون نسبت به پیش آزمون داشت (001/0=p ) که این افزایش در گروه کنترل معنی دار نبود (081/0=p ). داده های پژوهش حاضر نشان داد تمرینات هوازی-مقاومتی با افزایش بیان ژن PPAR می تواند در متابولیسم چربی ها و فرآیند های وابسته به آن در بیماران بای پس عروق کرونری تأثیرگذار باشد.

چکیده انگلیسی:

Gamma-factor progesterone proliferation activating receptors are a ligand-activated transcription factor playing an important role in lipid metabolism. The present study was aimed at evaluating the effect of eight weeks of aerobic-resistance training on the expression of gamma progesterone proliferator-activating receptor gene in patients with coronary artery bypass grafting. The research method was quasi-experimental and pre-test-post-test. The statistical population included all patients with coronary artery bypass grafting in Mashhad (Iran). Height 1.58 ± 0.03 (m), weight 68.11 ± 5.54 (kg), body mass index (BMI) 27.18 ± 2.47 (2 kg / m2) and disease history 75 8.75 ± 25/20 (month) were formed after coronary artery bypass surgery. According to the inclusion criteria, they were divided into experimental (14) and control (12) groups. Data were analyzed using independent t-test and paired t-test at the significance level of P≥0.05 and SPSS software version 21. The results showed that eight weeks of aerobic-resistance training increased the expression of PPARɣ gene in the combined training group compared to the control group (P = 0.001). Moreover, the results of the correlation test showed that the increase in PPAR gene expression in the combined training group had a significant increase in the post-test compared to the pre-test (P = 0.001), not significant in the control group (p = 0.081). The data of the present study showed that aerobic- resistance training with increasing PPARɣ gene expression could be effective in fat metabolism and related processes in patients with coronary artery bypass grafting.

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