Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds

محورهای موضوعی :

Rasim Farraj Muslim ¹ (Department of Environmental Sciences, College of Applied Sciences-Hit, University of Anbar, Hit, Anbar, Iraq)
Ismaeel Majeed ² (Department of chemistry, College of education for pure science-Ibn Al-Haitham University of Baghdad, Baghdad, Iraq)
Suheb Eaid Saleh ³ (Directorate of Education in Anbar, Ministry of Education, Ramadi, Anbar 31001, Iraq)
Marwan Mahmood Saleh ⁴ (Department of Biophysics, College of Applied Sciences-Hit, University of Anbar, Hit, Anbar, Iraq)
Mustafa Nadhim Owaid ⁵ (Department of Heet Education, Directorate of Education in Anbar, Ministry of Education, Hit, Anbar, Iraq)
Jalal Abdulkareem Abbas ⁶ (Department of Chemistry, Faculty of Science, Gazi University, Teknikokullar, Ankara, Turkey)

تاریخ دریافت : 1400/07/03 تاریخ پذیرش : 1400/09/06 تاریخ انتشار : 1401/09/10

کلید واژه: Biological activity, Heterocyclic, Oxazolidine-5-one, MICs,

چکیده مقاله :

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J1-J5 derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff's bases were synthesized. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J1-J5 derivatives. The compounds J1-J5 were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 μg ml-1 for J4 against the two pathogenic bacteria, while J1, J4, and J1 did not show any inhibitory effect against all bacteria. Finally, the best chemical created, 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J4), inhibited the development of both gram-negative and positive bacteria.

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