• صفحه اصلی
  • The Efficiency of Photodynamic Therapy in the Management of Pain in Patients with Oral Lichen Planus

اشتراک گذاری

آدرس مقاله


کد مقاله : 686355 بازدید : 135 صفحه: 189 - 196

10.22034/jchr.2021.686355

نوع مقاله: پژوهشی

The Efficiency of Photodynamic Therapy in the Management of Pain in Patients with Oral Lichen Planus

محورهای موضوعی :

Mona Abdallah Sabry 1 (Assistant Researcher, Surgery and Oral Medicine Department, National Research Center (NRC), Giza, Egypt)
Ali Mohamed Saafan 2 (Professor of Dental Laser applications, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Egypt)
Hanaa Mohamed El-Shennawy 3 (Professor of Oral & Dental Laser applications, Surgery and Oral Medicine department, National Research Center (NRC), Giza, Egypt)
Amal Ali Hussine 4 (Associate professor of Oral Medicine & Periodontology, Faculty of Oral &Dental Medicine, Cairo University, Egypt)
Doaa Mohamed Abd El- Aziz 5 (Associate professor of Chemical & Clinical Pathology, Faculty of Medicine, Ain Shams University, Egypt)
Doaa Ahmed Abdel Fadeel 6 (Lecturer of Laser Applications in Pharmaceutical Sciences, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Egypt)

تاریخ دریافت : 1400/04/16 تاریخ پذیرش : 1400/06/24 تاریخ انتشار : 1400/07/09

کلید واژه: pain, Oral lichen planus, Photodynamic therapy,

چکیده مقاله :

Photodynamic therapy (PDT) which is a type of photochemotherapy is a new method of treatment used in cases of erosive/atrophic oral lichen planus (OLP) to reduce symptoms of the disease. Assessment of the effect of PDT on pain scale in patients having erosive / atrophic oral lichen planus.30 patients having erosive/atrophic OLP were recruited in this study. The oral lesions were subjected to PDT twice per week for 2 months. Methylene blue (MB) oral gel was used as a photosensitizer applied to the oral lesions, then diode laser of 650 nm WL and 150 mW (milli Watts) powers was used in a non- contact mode for 2:30 minutes. Visual analogue scale (VAS); pain scale was used for clinical assessment. The results showed improvement in the severity of pain over the duration of treatment. There was a gradual decrease of the mean VAS score over 8 weeks duration from 8±1 to 4±2. The decrease was statistically significant in the mean VAS score in the first month from 7±2 to reach 5±2 by the end of the second month (p<0.001). The use of photodynamic therapy was found to be effective in management of erosive / atrophic OLP; it showed improvement in the subjective as well as objective signs and symptoms of the disease with no side effects.

چکیده انگلیسی:

منابع و مأخذ:


  1. Sapp J.P., Eversole L.R., Wysocki G.P., 1997. Contemporary oral and maxillofacial pathology. 1st ed., Elsevier, Mosby.
    2.
  2. Amirchaghmaghi M., Delavarian Z., Iranshahi M., Shakeri M.T., Mosannen M.P., Mohammadpour A.H., Farazi F., Iranshahy M., 2015. A Randomized Placebo-controlled Double Blind Clinical Trial of Quercetin for Treatment of Oral Lichen Planus. J Dent Res Dent Clin Dent Prospects. 9(1), 23-8.
    3.
  3. Jayachandran S., Koijam S., 2012. Management of Oral Lichen Planus: A Clinical Study. JIMSA. 25(3), 205-208.
    4.
  4. Sugerman P.B., Savage N.W., Walsh L.J., Zhao Z.Z., Zhou X.J., Khan A., 2002. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med. 13(4), 350-65.
    5.
  5. Lozada-Nur F. & Miranda C., 1997. Oral lichen planus: topical and systemic therapy. Semin Cutan Med Surg. 16, 295–300.
    6.
  6. Sousa F.A., Rosa L.E., 2008. Oral lichen planus: Clinical and histopathologi­cal considerations. Bras J Otorhinolaryngol. 74, 248-92.
    7.
  7. Chitturi R.T., Devy A.S., Nirmal R.M., 2014. Oral lichen planus: a review of etiopathogenesis, clinical, histological and treatment aspects. J Interdisciplinary Med Dent Sci. 2(5), 1-5.
    8.
  8. Eisen D.,1999. The evaluation of cutaneous, genital, scalp, nail, esophageal, and ocular involvement in patients with oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 88, 431-436.
    9.
  9. Sobaniec S., Bernaczyk P., Pietruski J., 2013. Clinical assessment of the efficacy of photodynamic therapy in the treatment of oral lichen planus. Lasers Med Sci. 28, 311-316.
    10.
  10. Saleh W.E., Khashaba O.H., El- nagdy S., Moustafa M.D., 2014. Photodynamic therapy of oral erosive lichen Planus in Diabetic and Hypertensive Patients. Mansoura Journal of Dentistry. 1(3), 119-123.
    11.
  11. Nelke K.H., Pawlak W., Leszczyszyn J., Gerber H., 2014. Photodynamic therapy in head and neck cancer. Postepy Hig Med Dosw. 68, 119-128.
    12.

 

  1. Jurczyszyn K., Ziółkowski P., Gerber H., Osiecka B.J., 2007. Potentiality of Photo-dynamic therapy in dentistry–Literature Review. Dent Med Probl. 44(2)255–258.
    2.
  2. Zeitouni N.C., Shieh F.S., Oseroff A.R., 2001. Laser and photodynamic therapy in the management of cutaneous malignancies. Clinics Dermatol. 19, 328–339.
    3.
  3. Chen Y., Zheng W. Y., Zhong J.J., Shen P., 2008. Apoptosis induced by methylene-blue-mediated photodynamic therapy in melanomas and the involvement of mitochondrial dysfunction revealed by proteomics. Cancer Sci. 99(10), 2019-2027.
    4.
  4. Mostafa D., Tarakji B., 2015. Photodynamic Therapy in Treatment of Oral Lichen Planus. J Clin Med Res. 7(6), 393-399.
    5.
  5. Baccaglini L., Thongprasom K., Carrozzo M., Bigby M., 2013. Urban legends series: lichen planus. Oral Dis. 19, 128–43.
    6.
  6. Thongprasom K., Prapinjumrune C., Carrozzo M., 2013. Review article: Novel therapies for oral lichen planus. J Oral Pathol Med. 42(10), 721-727.
    7.
  7. Soliman M., El Kharbotly A., Saafan A., 2005. Management of oral lichen planus using diode laser (980nm). A clinical study. Egy Derm. 1, 1-12.
    8.
  8. Cavalcanti T.M., Catão M.H., Lins R.D., Almeida-Barros R.Q., Feitosa A.P., 2011. Knowledge of the physical properties and interaction of laser with biological tissue in dentistry. A Bras Dermatol. 86, 955-960.
    9.
  9. Kulekcioglu S., Sivrioglu K., Ozcan O., Parlak M., 2003. Effectiveness of low-level laser therapy in temporomandibular disorder. Scand J Rheumatol. 32(2), 114-118.
    10.
  10. Pavlic V., Vujic-Aleksic V., 2014. Phototherapy approaches in treatment of oral lichen planus. Photodermatol Photoimmunol Photomed. 30, 15-24.
    11.
  11. Rad M., Hashemipoor M.A., Mojtahedi A., 2009. Correlation between clinical and histopathologic diagnosis of oral lichen planus based on modified WHO diagnostic criteria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 107, 796–800.
    12.
  12. Boddupalli B.M., Mohammed Z.K., Nath R.A., Banji D., 2010. Mucoadhesive drug delivery system: An overview. Journal of Advanced Pharmaceutical Technology & Research. 1(4), 381.
    13.
  13. Aslani A., Ghannadi A., Najafi H., 2013. Design, formulation and evaluation of a mucoadhesive gel from Quercus brantii L and coriandrum sativum L as periodontal drug delivery. Adv Biomed Res. 13(6), 484-493.
    14.
  14. Cafaro A., Arduino P.G., Massolini G., Romagnoli E., Broccoletti R., 2014. Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Lasers Med Sci. 29, 185-190.
    15.
  15. Othman N.A., Shaker O.G., Elshenawy H.M., 2016. The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients. J Clin Exp Dent. 8(5), 566–570.
    16.
  16. Al-Maweri S.A., Ashraf S., Kalakonda B., 2018. Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review. J Oral Pathol Med. 47, 326–32.
    17.
  17. Ferri E.P., Gallo C.B., Abboud C.S., Yanaguizawa W.H., Horliana A.T., Silva D.D., Pavani C., Bussadori S.K., Nunes F.D., Mesquita-Ferrari R.A., Fernandes K.S., Rodrigues M.D., 2018. Efficacy of photobiomodulation on oral lichen planus: a protocol study for a double-blind randomized controlled clinical trial. BMJ Open. 8(10), 1-7.
    18.
  18. Wiriyakijja P., Fedele S., Porter S.R., 2018. Patient-reported outcome measures in oral lichen planus: A comprehensive review of the literature with focus on psychometric properties and interpretability. J Oral Pathol Med. 47, 228–39.
    19.
  19. Manda G., Nechifor M., 2009. Reactive oxygen species, cancer and anti-cancer therapies. Curr Chem Biol. 3, 22-46.
    20.
  20. Mostafa D., Moussa E., Alnouaem M., 2017. Evaluation of Photodynamic Therapy in Treatment of Oral Erosive Lichen Planus in Comparison with Topically Applied Corticosteroids. Photodiagnosis and Photodynamic Therapy. 19, 56-66.
    21.
  21. Aghahosseini F., Fateh M., Djavid G., 2006. Treatment of oral lichen planus with photodynamic therapy mediated methylene blue: a case report. Med Oral Patol Oral Cir Buccal. 11(2), 126-129.
    22.
  22. Maloth K.N., Velpula N., Kodangal S., 2016. Photodynamic Therapy - A Non-invasive Treatment Modality for Precancerous Lesions. J Lasers Med Sci. 7(1), 30–36.
    23.
  23. Jajarm H.H., Falaki F., Sanatkhani M., Ahmadzadeh M., Ahrari F., Shafaee H., 2015. A comparative study of toluidine blue-mediated photodynamic therapy versus topical corticosteroids in the treatment of erosive-atrophic oral lichen planus: a randomized clinical controlled trial. Lasers Med Sci. 30(5), 1475–1480.
    24.
  24. Sulewska M., Duraj E., Sobaniec S., Graczyk A., Milewski R., Wróblewska M., Pietruski J., Pietruska M., 2017. A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: A case series. Photodiagnosis Photodyn Ther. 18, 12-19.
    25.
  25. Pandeshwar P., Roa M.D., Das R., 2016. Photobiomodulation in oral medicine: a review. J Investig Clin Dent. 7, 114–26.
    26.
  26. Lynch D., Haddad S., King V., Ott M., Straight R., Jolles C., 1989. Systemic immunosuppression induced by photodynamic therapy (PDT) is adoptively transferred by macrophages. Photochem Photobiol. 49(4), 453–458.
    27.
  27. Simkin G., Tao J., Levy J., Hunt D., 2000. IL-10 contributes to the inhibition of contact hypersensitivity in mice treated with photodynamic therapy. J Immunol. 164(5), 2457–2462.
    28.
  28. Qin B., Selman S., Payne K., Keck R., Metzger D., 1993. Enhanced Skin allograft survival after photodynamic therapy. Association with lymphocyte inactivation and macrophage stimulation. Transplantation. 56(6), 1481–1486.
    29.
  29. Chowdhary R., Ratkay L., Neyndorff H., Richter A., Obochi M., Waterfield J., Levy J., 1994. The use of transcutaneous photodynamic therapy in the prevention of adjuvant-enhanced arthritis in MRL/lpr mice. Clin Immunol Immunopathol. 72(2), 255–263.
    30.
  30. Mroz P., Hamblin M.R., 2011.The immunosuppressive side of PDT. Photochem Photobiol Sci. 10(5), 751–758.
    31.

سکوی نشر دانش

سند یا سکوی نشر دانش ،سامانه ای جهت مدیریت حوزه علمی و پژوهشی نشریات دانشگاه آزاد می باشد

پیوندهای سایت

مراکز مرتبط

پشتیبانی

صفحات رسمی

حقوق این وب‌سایت متعلق به سامانه مدیریت نشریات دانشگاه آزاد اسلامی است.
حق نشر © 1403-1400

صفحه اصلی| عضویت/ ورود| درباره سند| تماس با ما|
[English] [العربية] [en] [ar]