Some Biochemical Parameters and Level of Preptin in Newly Diagnosed Type 2 Diabetic Women Patients in Tikrit City
محورهای موضوعی :
Firas Faris Rija
1
,
Marwah Isam Sulaiman Musa
2
,
Hind T. Hamad
3
1 - Department of Biology, College of Science, Tikrit University, Tikrit, Iraq
2 - Department of Biology, College of Science, Tikrit University, Tikrit, Iraq
3 - Department of Prostheses, Al-Dour Technical Institute, Northern Technical University, Saladin, Iraq
تاریخ دریافت : 1400/01/09
تاریخ پذیرش : 1400/04/04
تاریخ انتشار : 1401/03/11
کلید واژه:
HbA1c,
Diabetes,
Preptin,
Type 2 DM,
Mellitus,
چکیده مقاله :
A chronic disease categorized by high blood sugar called diabetes mellitus (DM), Its prevalence is rapidly increasing all over the world. Peptin is a peptide produced by cells of pancreas. It plays as a physiologic enhancer of glucose-mediated insulin secretion. There, the current study aimed to note differences in the levels of newly diagnosed patients with T2DM controls. This study was directed at Salah el-Deen medical Clinic in Tikrit city and included women from Salah al-Din Hospital in Tikrit in the period since Feb to Jul 2020, 40 newly diagnosed patients T2DM and 40 healthy elderly women. Preptin, Hba1c, fasting blood glucose (FBS), blood urea (BU), and serum creatinine levels will be examined. The present study discovered a significant rise in Preptin (362.460.01pg ml-1), Hba1c (8.82.7 %), FBS (205±25.7mg dl-1), BU (20.71 ±4.3 mmol l-1), and creatinine (1.1±0.2mg dl-1) in female T2DM patients compared to the control group (222.8±30.7pg ml-1, 4.6±1.3 %, 99±15. The observed link between preptin level and diabetes mellitus a suggests that this peptide may play a role in the pathogenesis of DM, which may be of particular interest to a group DM that constitutes a major public health problem.
منابع و مأخذ:
American Diabetes Association, “2. Classification and diagnosis of diabetes: Standards of medical care in diabetes—2018, Diabetes Care, vol. 41, no. Supplement 1. pp. S13–S27,
International Diabetes Federation. IDF Diabetes Atlas. 8th edition. Brussels: International Diabetes Federation; 2017.
Akın S., Erdem M.E., Kazan S., Aliustaoğlu M., 2014. The relationship between helicobacter pylori infection and glycemic regulation intype 2 diabetic patients. Nobel Med.10, 32–5.
Cakir M., Ozcan S.S., Korkmaz M., Durusoy S., 2019. Decreased levels of plasma preptin in female patients with knee osteoarthritis. Annals of Medical Research. 26(9), 1805-1808.
Tomova I., Stoyanov G.S., Dzhenkov D.L., Petkova L., 2020. Late Pathomorphological Features of the Endocrine Pancreas in Patients With Type 2 Diabetes Mellitus. Cureus. 12(6), e8777. doi:10.7759/cureus.8777
Hamzah M.I., Kareem I.A.A., Al-bayati M., 2020. Expression of Amylin and Preptin in Iraqi Patients with Type 2 Diabetes Mellitus. Indian Journal of Public Health Research & Development. 11(2), 1384-1388.
Cakir M., Ozcan S.S., Korkmaz M., Durusoy S., 2019. Decreased levels of plasma preptin in female patients with knee osteoarthritis. Annals of Medical Research. 26(9), 1805-1808.
Yang G., Li L., Chen W., Liu H., Boden G. Li K., 2009. Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Annals of Medicine. 41(1), 52-56.
Celik O., Celik N., Hascalik S., Sahin I., Aydin S. Ozerol E., 2011. An appraisal of serum preptin levels in PCOS. Fertility and Sterility. 95(1), 314-316.
Cakir M., Ozcan S.S., Korkmaz M., Durusoy S., 2019. Decreased levels of plasma preptin in female patients with knee osteoarthritis. Annals of Medical Research. 26(9), 1805-1808.
Sunlong Biotech Co. Human Elisa kit. Availablefrom:https://www.sunlongbiotech.com/gory.php?id=66.[Accessed 2 December 2020].
Cakir M., Ozcan S.S., Korkmaz M., Durusoy S., 2019. Decreased levels of plasma preptin in female patients with knee osteoarthritis. Annals of Medical Research. 26(9), 1805-1808.
Reid I.R., 2002. Relationships among body mass, its components, and bone. Bone. 31(5), 547-555.
Rija F.F., Almahdawi Z.M.M. Hussein S.Z., 2019. Correlation between calcium sensing receptor with other calcium regulators in osteoporosis and osteomalacia patients. Plant Archives. 19(1), 1199-1207.
