Smirnovia Iranica Whole Herb Extract: Antioxidant, Radical Scavenging, Anti-microbial and Anti-Cancer Effects
محورهای موضوعی :
Leila Monjazeb Marvdashti
1
(
Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran|Cancer Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran
)
Samaneh Arab
2
(
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran|Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
)
Marjan Bahraminasab
3
(
Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran|Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
)
Mina Roustaei
4
(
Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran
)
Samaneh Souri
5
(
Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran
)
Mojtaba Heydari Majd
6
(
Zabol University of Medical Sciences, Zabol, Iran
)
Anna Abdolshahi
7
(
Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran
)
تاریخ دریافت : 1400/08/05
تاریخ پذیرش : 1400/12/18
تاریخ انتشار : 1402/03/11
کلید واژه:
Smirnovia iranica,
IC50,
Anti-Microbial Agents,
Anti-Oxidant effect,
Anticancer agent,
چکیده مقاله :
In this study, the biological activities of whole herb extract of a medicinal plant named Smirnovia Iranica were investigated. The extraction was performed using Supercritical CO2 and phytochemical compounds, total phenolic content (TPC), total flavonoid content (TFC), antioxidant, anti-bacterial, and anti-cancer effect were determined in the extract. Based on the results, high TPC concentration (120.36 mg GAE/100 g FW) and TFC (17.41 mg quercetin/100g FW) were obtained in the extract. Besides, the extract showed significant antioxidant activity (IC50=53.97 µg mL-1). Moreover, the extract showed a notable inhibitory effect againstEscherichia coli(MIC=15.63 mg mL-1) andSalmonella enterica (MIC=31.25 mg mL-1). On the other hand, this extract showed the cytotoxic effect on glioblastoma cancer cell lines in the MTT assay. This is the first, yet comprehensive, scientific report about the chemical composition and pharmacological properties of the extract of Smirnovia Iranica whole herb. According to current results, the Smirnovia Iranica extract has excellent antioxidant properties for application as bioactive components for various objects such as as food supplements. The experiment confirmed the efficacy of the extracts as natural antimicrobials and suggested the possibility of employing them in drugs for the treatment of infectious diseases caused by the test organisms.
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