• صفحه اصلی
  • The Effects of Two Weeks Quercetin Supplementation in Adolescent Swimmer Girls on The Oxidative Stress and Inflammatory Mediator’s Response to Acute Swimming Session

اشتراک گذاری

آدرس مقاله


کد مقاله : JCHR-2106-1344 (R1) بازدید : 207 صفحه: 599 - 607

10.22034/jchr.2021.1934089.1344

نوع مقاله: پژوهشی

The Effects of Two Weeks Quercetin Supplementation in Adolescent Swimmer Girls on The Oxidative Stress and Inflammatory Mediator’s Response to Acute Swimming Session

محورهای موضوعی :

Masoumeh Gholaman 1 , Maryam Khodabakhsh Nokola 2 , Zahra Ghorbani Ganjeh 3 , Shokoufeh Sokhanvardastjerdi 4 , Mandana Gholami 5 , Maryam Kasiri 6

1 - Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 - Department of Exercise Physiology, South Branch, Islamic Azad University, Tehran, Iran
5 - Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
6 - Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

تاریخ دریافت : 1400/04/05 تاریخ پذیرش : 1400/08/15 تاریخ انتشار : 1402/06/10

کلید واژه: Inflammation, Oxidative stress, Quercetin,

چکیده مقاله :

Quercetin could modulate the oxidative stress and inflammation, but its effects on exercise related oxidative stress and inflammation has attracted little attention. The present study conducted aimed to identify the effect of quercetin supplementation on oxidative stress and inflammatory mediator’s response following the acute swimming session. In semi-experimental study, the 20 trained swimmer girls (15.1±0.21 yrs old and BMI, 21.05±2.3 kg m-2) randomly allocated in two equal groups including quercetin (n= 10) and placebo (n= 10) groups. Subjects in quercetin group received 1000 mg quercetin daily for two weeks. Subsequently, participants completed the high intensity (>85% MHR) exhausting swimming session. In order to measurement the inflammatory (IL-6, CRP) and oxidative stress related markers, blood samples collected at the baseline, pre (after two-week quercetin supplementation) and immediately after completing the swimming session. Repeated-measures ANOVA test used for data analysis and significant levels considered at p<0.05. IL-6 significantly increased immediately after exercise in both groups (p<0.001), but IL-6 response to exercise in quercetin group was significantly less than placebo group (p<0.05). However, CRP don’t show significant changes (p>0.05). TAC doesn’t change, but significant increase in MDA, SOD, GPx and Catalase were observed in placebo and quercetin group immediately after swimming session (p<0.05) and MDA response to exercise session in quercetin group was significantly lower compared to placebo group (p<0.05). Quercetin modulated the IL-6 and MDA response after exhausting exercise and Quercetin can be considered as supplement for combating exercise induced inflammation and oxidative stress.

چکیده انگلیسی:

منابع و مأخذ:


  1. Yin J., Ren W.K., Wu X.S., Yang G., Wang J., Li T.J., Ding J.N., Cai L.C., Su D.D., 2013. Oxidative stress-mediated signaling pathways: a review. J. Food Agric. Environ. 11(2), 132-139.
    2.
  2. Singh Z., Karthigesu I.P., Singh P., Rupinder K.A.U.R., 2014. Use of malondialdehyde as a biomarker for assessing oxidative stress in different disease pathologies: a review. Iranian J Public Health. 43(3), 7-16.
    3.
  3. Giera M., Lingeman, H., Niessen W.M., 2012. Recent advancements in the LC-and GC-based analysis of malondialdehyde (MDA): a brief overview. Chromatographia. 75(9-10), 433-440.
    4.
  4. Lee S.G., Wang T., Vance T.M., Hurbert P., Kim D.O., Koo S.I., Chun O.K., 2017. Validation of analytical methods for plasma total antioxidant capacity by comparing with urinary 8-isoprostane level. J Microbiol Biotechnol. 27(2), 388-394.
    5.
  5. Bondia-Pons I., Ryan L., Martinez J.A., 2012. Oxidative stress and inflammation interactions in human obesity. J Physiol Biochem. 68(4), 701-711.
    6.
  6. Hasegawa H., Mizoguchi I., Chiba Y., Ohashi M., Xu M., Yoshimoto T., 2016. Expanding diversity in molecular structures and functions of the IL-6/IL-12 heterodimeric cytokine family. Front Immunol. 7,479.
    7.
  7. Fischer C.P., Berntsen A., Perstrup L.B., Eskildsen P., Pedersen B.K., 2007. Plasma levels of interleukin‐6 and C‐reactive protein are associated with physical inactivity independent of obesity. Scand J Med Sci Sports. 17(5), 580-587.
    8.
  8. D’aiuto F., Nibali L., Parkar M., Patel K., Suvan, J., Donos N., 2010. Oxidative stress, systemic inflammation, and severe periodontitis. J Dent Res. 89(11), 1241-46.
    9.
  9. Roberts C.K., Won D., Pruthi S., Kurtovic S., Sindhu R.K., Vaziri N.D., Barnard R.J., 2006. Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors. J Appl Physiol. 100(5), 1657-65.
    10.
  10. Sallam N., Laher I., 2016. Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases. Oxid Med Cell Longev. 7239639.
    11.
  11. Wadley A.J., Chen Y.W., Lip G.Y., Fisher J.P., Aldred S., 2016. Low volume–high intensity interval exercise elicits antioxidant and anti-inflammatory effects in humans. J Sports Sci. 34(1), 1-9.
    12.
  12. Freitas D.A., Rocha-Vieira E., Soares B.A., Nonato L.F., Fonseca S.R., Martins J.B., Mendonça V.A., Lacerda A.C., Massensini A.R., Poortamns J.R., Meeusen R., 2018. High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats. Physiol Behav. 184, 6-11.
    13.
  13. Bogdanis G.C., Stavrinou P., Fatouros I.G., Philippou A., Chatzinikolaou A., Draganidis D., Ermidis G., Maridaki M., 2013. Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans. Food Chem Toxicol. 61, 171-7.
    14.
  14. Zhang H., Tsao R., 2016. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr. Opin Food Sci. 8, 33-42.
    15.
  15. Rauf A., Imran M., Khan I.A., ur‐Rehman M., Gilani S.A., Mehmood Z., Mubarak M.S., 2018. Anticancer potential of quercetin: A comprehensive review. Phytother Res. 32(11), 2109-2130.
    16.
  16. Patel, R.V., Mistry, B.M., Shinde, S.K., Syed, R., Singh, V., Shin, H.S., 2018. Therapeutic potential of quercetin as a cardiovascular agent. Eur J Med Chem. 155, 889-904.
    17.
  17. Xu D., Hu M.J., Wang Y.Q., Cui Y.L., 2019. Antioxidant activities of quercetin and its complexes for medicinal application. Molecules. 24(6), 1123.
    18.
  18. Gholami M., Ardestani M., 2018. Effects of Quercetin Supplementation on Exercise Induced Inflammation and Immune Cell Changes After Exhausting Swimming in Adolescent Girls. Asian J Sport Med. 9(3), e60157.
    19.
  19. Morillas-Ruiz J.M., García J.V., López F.J., Vidal-Guevara M.L., Zafrilla P., 2006. Effects of polyphenolic antioxidants on exercise-induced oxidative stress. Clin Nutr. 25(3), 444-453.
    20.
  20. O’Fallon K.S., Kaushik D., Michniak-Kohn B., Dunne C.P., Zambraski E.J., Clarkson P.M., 2012. Effects of quercetin supplementation on markers of muscle damage and inflammation after eccentric exercise. Int J Sport Nutr Exerc Metab. 22(6), 430-437.
    21.
  21. Askari G., Ghiasvand R., Paknahad Z., Karimian J., Rabiee K., Sharifirad G., Feizi A., 2013. The effects of quercetin supplementation on body composition, exercise performance and muscle damage indices in athletes. Int J Prev Med. 4(1), 21-6.
    22.
  22. Penry J.T., Wilcox A.R., Yun J., 2011. Validity and reliability analysis of Cooper's 12-minute run and the multistage shuttle run in healthy adults. J Strength Cond Res. 25(3), 597-605.
    23.
  23. Cooper K.H., 1968. A means of assessing maximal oxygen intake: correlation between field and treadmill testing. JAMA. 203(3), 201-204.
    24.
  24. Nieman D.C., Henson D.A., Davis J.M., Angela Murphy E., Jenkins D.P., Gross S.J., Carmichael M.D., Quindry J.C., Dumke C.L., Utter A.C., McAnulty S.R., 2007. Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA. J Appl Physiol. 103(5), 1728-1735.
    25.
  25. Ahmadizad S., Avansar A.S., Ebrahim K., Avandi M., Ghasemikaram M., 2015. The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers. Horm Mol Biol Clin Investig. 21(3), 165-173.
    26.
  26. Azizbeigi K., Stannard S.R., Atashak S., Haghighi M.M., 2014. Antioxidant enzymes and oxidative stress adaptation to exercise training: Comparison of endurance, resistance, and concurrent training in untrained males. J Exerc Sci Fit. 12(1), 1-6.
    27.
  27. Baghaiee B., Teixeira A.B., Tartibian B., 2016. Moderate aerobic exercise increases SOD-2 gene expression and decreases leptin and malondialdehyde in middle-aged men. Sci & Sport. 31(3), 55-63.
    28.
  28. Benzie I.F., Strain J.J., 1999. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol. 299, 15-27.
    29.
  29. McKenzie M.J., Goldfarb A., Garten R.S., Vervaecke L., 2014. Oxidative stress and inflammation response following aerobic exercise: role of ethnicity. Int J Sports Med. 35(10), 822-827.
    30.
  30. Febbraio M.A., Pedersen B.K., 2002. Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles. The FASEB J. 16(11), 1335-1347.
    31.
  31. Pedersen B.K., Fischer C.P., 2007. Beneficial health effects of exercise–the role of IL-6 as a myokine. Trends Pharmacol Sci. 28(4), 152-156.
    32.
  32. Kasapis C., Thompson P.D., 2005. The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol. 45(10), 1563-1569.
    33.
  33. Aguirre L., Arias N., Teresa Macarulla M., Gracia A., P Portillo M., 2011. Beneficial effects of quercetin on obesity and diabetes. Open Nutraceuticals J. 4(1), 189-198.
    34.
  34. McAnulty S.R., McAnulty L.S., Nieman D.C., Quindry J.C., Hosick P.A., Hudson M.H., Still L., Henson D.A., Milne G.L., Morrow J.D., Dumke C.L., 2008. Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation. Appl Physiol Nutr Metab. 33(2), 254-262.
    35.
  35. Nair M.P., Kandaswami C., Mahajan S., Chadha K.C., Chawda R., Nair H., Kumar N., Nair R.E., Schwartz S.A., 2002. The flavonoid, quercetin, differentially regulates Th-1 (IFNγ) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells. Biochim Biophys Acta. 1593(1), 29-36.
    36.
  36. Li Y., Yao J., Han C., Yang J., Chaudhry M.T., Wang S., Liu H., Yin Y., 2016. Quercetin, inflammation and immunity. Nutrients. 8(3), 167.
    37.
  37. Konrad M., Nieman D.C., Henson D.A., Kennerly K.M., Jin F., Wallner-Liebmann S.J., 2011. The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. Int J Sport Nutr Exerc Metab. 21(4), 338-346.
    38.
  38. Askari G., Ghiasvand R., Feizi A., Ghanadian S.M.,Karimian J., 2012. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci. 17(7), 637-41.
    39.
  39. Fisher G., Schwartz D.D., Quindry J., Barberio M.D., Foster E.B., Jones K.W., Pascoe D.D., 2011. Lymphocyte enzymatic antioxidant responses to oxidative stress following high-intensity interval exercise. J Appl Physiol. 110(3), 730-737.
    40.
  40. Belviranlı M., Gökbel H., 2006. Acute exercise induced oxidative stress and antioxidant changes. Eur J Gen Med. 3(3), 126-31.
    41.
  41. Watson T.A., Callister R., Taylor R.D., Sibbritt D.W., MacDonald-Wicks L.K., Garg M.L., 2005. Antioxidant restriction and oxidative stress in short-duration exhaustive exercise. Med Sci Sports Exerc. 37(1), 63-71.
    42.
  42. Accattato F., Greco M., Pullano S.A., Carè I., Fiorillo A.S., Pujia A., Montalcini T., Foti D.P., Brunetti A., Gulletta E., 2017. Effects of acute physical exercise on oxidative stress and inflammatory status in young, sedentary obese subjects. PloS one. 12(6), e0178900.
    43.
  43. Ribeiro-Samora G.A., Rabelo L.A., Ferreira A.C.C., Favero M., Guedes G.S., Pereira L.S.M., Parreira V.F., Britto R.R., 2017. Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration. Braz J Med Biol Res. 50(9), e6393.
    44.
  44. Quindry J.C., McAnulty S.R., Hudson M.B., Hosick P., Dumke C., McAnulty L.S., Henson D., Morrow J.D., Nieman D., 2008. Oral quercetin supplementation and blood oxidative capacity in response to ultramarathon competition. Int J Sport Nutr Exerc Metab. 18(6), 601-616.
    45.
  45. Shanely R.A., Knab A.M., Nieman D.C., Jin F., McAnulty S.R., Landram M.J., 2010. Quercetin supplementation does not alter antioxidant status in humans. Free Radic Res. 44(2), 224-231.
    46.

سکوی نشر دانش

سند یا سکوی نشر دانش ،سامانه ای جهت مدیریت حوزه علمی و پژوهشی نشریات دانشگاه آزاد می باشد

پیوندهای سایت

مراکز مرتبط

پشتیبانی

صفحات رسمی

حقوق این وب‌سایت متعلق به سامانه مدیریت نشریات دانشگاه آزاد اسلامی است.
حق نشر © 1403-1400

صفحه اصلی| عضویت/ ورود| درباره سند| تماس با ما|
[English] [العربية] [en] [ar]