The Effect of ANGIPARS™ on Wound Healing in Patients with Diabetes: A Systematic Review
محورهای موضوعی :Mohamad Karimian 1 , Ali Gholami 2 , Mohammad Hosein Farzaei 3 , Azzurra Stefanucci 4 , Adriano Mollica 5 , Yosof Mahmoudi 6 , sana shahrabady 7 , asma tarjoman 8 , Milad Borji 9
1 - Assistant Professor of Vascular Surgery, clinical research development center of Imam Khomeini Hospital, Ilam University of Medical Science, Ilam, Iran
2 - Assistant Professor of Anesthesiology, Department of Anesthesiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 - Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 - Department of Pharmacy, G. d'Annunzio University of Chieti-pescara, Chieti 66100, Italy
5 - Department of Pharmacy, G. d'Annunzio University of Chieti-pescara, Chieti 66100, Italy
6 - Student Research committee, kermanshah University of Medical Sciences, kermanshah, Iran
7 - master of psychiatric nursing, Young Researchers Club, School of nursing, Islamic Azad University, Bandargaz Branch, Bandargaz, Iran
8 - Student Research committee, Ilam University of Medical Sciences, Ilam, Iran
|Zoonotic Disease Research Center, Ilam University of Medical Sciences, Ilam, Iran
9 - Department of Nursing, Faculty of Nursing and Midwifery, kermanshah University of Medical Science, kermanshah, Iran
کلید واژه: Systematic Review, Diabetic Foot Ulcer, Angioparesis,
چکیده مقاله :
About 15% of patients with diabetes develop a Diabetic foot ulcer (DFU). It is an open sore or wound commonly located on the bottom of the foot.ANGIPARS™ is an Iranian-produced herbal remedy based on the extract of Melilotus officinalis. The aim of this study was to make a systematic review focused on determination of the effect of ANGIPARS™ on wound healing in patients with diabetes. The study was conducted in accordance with the PRISMA guidelines. Articles included in the review cover the period from the discovery of ANGIPARS™ to August 18, 2018. The data were analyzed using a descriptive method of Excel 2007 Software.Five articles with total number of 171 patients were included in the systematic review (SR) phase. In three articles, the methods were based on mm2 units and in the two others on cm2 units. Patients' follow-up varied from 4 weeks to 6 months after the intervention. In all patients, ANGIPARS™ responds well to the DFU disease. Due to the positive effect of the herbal drug, it is recommended to administer it for wound healing in patients with diabetes.
1. Azami G., Soh K.L., Sazlina S.G., Salmiah M.S., Aazami S., Mozafari M., Taghinejad H., 2018. Effect of a nurse-led diabetes self-management education program on glycosylated hemoglobin among adults with type 2 diabetes. Journal of Diabetes Research. 26(141), 192-204. https://doi.org/10.1155/2018/4930157
2. Azami G., Lam S.K., Shariff-Ghazali S., Said S.M., Aazami S., Mozafari M., 2018. Validation of the Iranian/Persian version of the perceived therapeutic efficacy scale for type 2 diabetes. Arch Iran Med. 21(8), 356–361.
3. Taghinejad H., Tavan H., 2018. Evaluating the Effect of Using Training CDs on the Patients with Type II Diabetes. Iran J Public Health. 47(2), 301-302.
4. Afzali H., Norouzirad R., Khaksari M., 2019. The Role of Nitric Oxide Donors in Wound Healing in Diabetes Mellitus. Iranian Journal of Endocrinology and Metabolism. 21(1), 46-57.
5. Almasi S., Salehiniya H., 2014. The prevalence of gestational diabetes mellitus in Iran (1993-2013): a systematic review. J Isfahan Med Sci. 32 (299), 1396-1412.
6. Azami M., Sayehmiri K., 2016. Prevalence of diabetes mellitus in Iranian patients with thalassemia major: a systematic review and meta-analysis. Journal of Mazandaran University of Medical Sciences. 26(141), 192-204.
7. Kiadaliri A.A., Najafi B., Mirmalek-Sani M., 2013. Quality of life in people with diabetes: a systematic review of studies in Iran. Journal of Diabetes & Metabolic Disorders. 12(1), 54-68. https://doi.org/10.1186/2251- 6581-12-54
8. Khalighi Z., Badfar G., Mahmoudi L., Soleymani A., Azami M., Shohani M., 2019. The prevalence of depression and anxiety in Iranian patients with diabetes mellitus: A systematic review and meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13(4), 2785-2794. DOI: 10. 1016 /j. dsx. 2019.07.004
9. Vouillarmet J., Josset-Lamaugarny A., Michon P., Saumet J. L., Koitka-Weber A., Henni S., Fromy B., Sigaudo-Roussel D., 2019. Neurovascular response to pressure in patients with diabetic foot ulcer. Diabetes. 68(4), 832-836.
10. Ibrahim A., 2017. IDF Clinical Practice Recommendation on the Diabetic Foot: A guide for healthcare professionals. Diabetes Research and Clinical Practice. 127, 285-287.
11. Moeini M., Shahriari M., Yousefi H., Esfandiari J., Babaahmadi M., 2017. An investigation on the wound severity and its association with predisposing factors in patients with diabetic foot. Journal of Clinical Nursing and Midwifery. 5(4), 67-75.
12. Rasekh A., 2011. Topical estrogen accelerates wound healing in diabetic rats. Iranian Journal of Endocrinology and Metabolism. 12(5), 544-551.
13. Crawford F., Inkster M., Kleijnen J., Fahey T., 2007. Predicting foot ulcers in patients with diabetes: a systematic review and meta-analysis. Journal of the Association of Physicians. 100(2), 65-86.
14. Aghakhani N., Broomand A., Alinejad V., Torabi M., Nikoonejad A., 2016. The effect of education on quality of life in patients with diabetic foot in educational hospital of urmia. The Journal of Urmia Nursing and Midwifery Faculty. 14(4), 380-388.
15. Bahrami A., Aliasgarzadeh A., Sarabchian M., Mobasseri M., Heshmat R., Gojazadeh N., 2010. Efficacy of oral ANGIPARS in chronic diabetes foot ulcer: a double blind placebo controlled study. Iranian Journal of Endocrinology and Metabolism. 11(6), 647-732.
16. Pastar I., Ojeh N., Glinos G.D., Stojadinovic O., Tomic-Canic M., 2018. Physiology and Pathophysiology of Wound Healing in Diabetes The Diabetic Foot. Springer. pp. 109-130.
17. Matos M., Mendes R., Silva A.B., Sousa N., 2018. Physical activity and exercise on diabetic foot related outcomes: a systematic review. Diabetes Research and Clinical Practice. 139, 81-90.
18. Subrata S., Phuphaibul R., Kanogsunthornrat N., Siripitayakunkit A., 2019. ADIE-nursing interventions of diabetic foot ulcer: An integrative review of the literature. Current diabetes reviews, 16(1), 40-51. DOI: https://doi.org/10.2174/1573399815666190307164119
19. Zanboori V., Ostovar A., Heshmat H., Larijani B., 2010. Randomized Double-Blind Placebo-Controlled Trial of AngiparsTM in Diabetic Foot Ulcer, Study Protocol. Journal of Diabetes and Metabolic Disorders. 9(1), 14-28,
20. Larijani B., Heshmat R., Bahrami A., Delshad H., Mohammad K., Heidarpour R., Kamali K., Farhadi M., Gharibdoust F., Madani S., 2008. Effects of intravenous Semelil (ANGIPARSTM) on diabetic foot ulcers healing: A multicenter clinical trial. DARU Journal of Pharmaceutical Sciences. 16 (Suppl. 1), 35-40.
21. Ebrahimi M., Bakhshayeshi S., Heshmat R., Shahbazi S., Aala M., Peimani M., Khushechin G., Tehrani M. M., Shojaeefard A., Kamali K., 2015. Post marketing surveillance on safety and effectiveness of ANGIPARS in treatment of diabetic foot ulcers. DARU Journal of Pharmaceutical Sciences. 1, 45-49.
22. Abdollahi M., Farzamfar B., Salari P., Khoram K.H., Farhadi M., Madani S., 2008. Evaluation of acute and sub-chronic toxicity of semelil (ANGIPARS™), a new phytotherapeutic drug for wound healing in rodents.
23. Farzamfar B., Abdollahi M., Kabinezhadian S., Heshmat R., Shah H.M.H., Novitsky Y., Farhadi M., 2008. Sub-chronic toxicity study of a novel herbal-based formulation (Semelil) on dogs. Compelete 16(Suppl. 1), 15-19.
24. HR K.K., Sadeghi B., Heshmat R., Abdollahi M., Salari P., Farzamfar B., Madani S.J.D.J. O.P.S., 2008. In vivo and in vitro genotoxicity studies of Semelil (ANGIPARSTM). 16 (Suppl. 1), 20-24.
25. Abdollahi M., Farzamfar B., Salari P., HR K.K., Larijani B., Farhadi M., Madani S., 2008. Evaluation of acute and sub-chronic toxicity of Semelil (ANGIPARSTM), a new phytotherapeutic drug for wound healing in rodents. DARU Journal of Pharmaceutical Sciences, 16 (Suppl. 1), 7-14.
26. Farzamfar B., Abdollahi M., Ka'abinejadian S., Heshmat R., Shahhosseiny M., Novitsky Y., Farhadi M., 2008. Sub-chronic toxicity study of a novel herbal-based formulation (Semelil) on dogs. DARU Journal of Pharmaceutical Sciences, 16 (Suppl. 1), 15-19.
27. HR K.K., Sadeghi B., Heshmat R., Abdollahi M., Salari P., Farzamfar B., Madani S., 2008. In vivo and in vitro genotoxicity studies of Semelil (ANGIPARSTM). DARU Journal of Pharmaceutical Sciences. 16(Suppl. 1), 20-24.
28. Asadi-Shekaari M., Vaghefi H.E., Talakoub A., Khorshid H.K., 2010. Effects of Semelil (ANGIPARS™) on focal cerebral ischemia in male rats. Daru: Journal of Faculty of Pharmacy. Tehran University of Medical Sciences. 18(4), 265-269. PMID: 22615626
29. Fleming P.S., Seehra J., Polychronopoulou A., Fedorowicz Z., Pandis N., 2012. A PRISMA assessment of the reporting quality of systematic reviews in orthodontics. The Angle Orthodontist. 83(1), 158-163.
30. Masoompour S., Bagheri M., Novitsky Y., Sadeghi B., Gharibdoust F., Larijani B., 2008. Effect of ANGIPARSTM, a new herbal drug on diabetic foot ulcer: A phase 2 clinical study. DARU Journal of Pharmaceutical Sciences. 16(Suppl. 1), 31-34.
31. Bahrami A., Kamali K., Ali-Asgharzadeh A., Hosseini P., Heshmat R., HR K.K., Gharibdoust F., Madani S., Larijani B., 2008. Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial. DARU Journal of Pharmaceutical Sciences. 16(Suppl. 1), 41-48.
32. Ansari G., Delbari A., Karimi M., Akbari Kamrani A. A., Abolfathi Momtaz Y., mohamadi s., Sahaf R., 2019. The Effect of Melilotous Officinalis Oil on the Physical Function of Older Adults With Mild to Moderate Knee Osteoarthritis: A Double-Blind Randomized Controlled Trial. Salmand: Iranian Journal of Ageing. 14(2), 132-143.
33. Wang Y., Cao H.J., Wang L.Q., Lu C.L., Yan Y.Q., Lu H., Zhang K., Zhang H.M., Liu J.P., 2019. The effects of Chinese herbal medicines for treating diabetic foot ulcers: A systematic review of 49 randomized controlled trials. Complementary Therapies in Medicine. 44, 32-4.
