Evaluation of Chronic and Acute Effects of Gabapentin on Passive Avoidance Learning Process in Mice

محورهای موضوعی :

Hormoz Ayromlou ¹ , Nooshin Masoudian ² , Naser Ahmadi-Asl ³ , Parisa Habibi ⁴ , Nahid Masoudian ⁵ , Sasan Andalib ⁶ , Maria Yazdani ⁷ , Hossein Akbari ⁸

1 - Neurosciences Research Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2 - Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 - Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 - Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
5 - Department of Biology, Collage of Basic Sciences, Damghan Branch, Islamic Azad University, Damghan, Iran
6 - Neurosciences Research Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
7 - Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
8 - Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

تاریخ دریافت : 1393/06/01 تاریخ پذیرش : 1397/08/07 تاریخ انتشار : 1397/08/07

کلید واژه:

چکیده مقاله :

Gabapentin (GBP) is one of the new antiepileptic drugs (AEDs) applied extensively in neurology and psychiatry. The advantage of new AEDs includes newer mechanism of action, broad spectrum of anti-seizure effects, lesser drug interactions and fewer side effects. GBP is a cyclized analogue of GABA but it does not interact with GABA receptors, nor does it inhibit GABA uptake or prevent the degeneration of GABA. Restricted studies have been performed on acute and chronic effects of GBP on passive avoidance (PA) learning and little is known about its chronic phase. Therefore, the aim of the present study was to evaluate acute and chronic effects of GBP on passive avoidance learning in 100 mice (w=30 gr). Ten mg/kg GBP were injected interaperitoneally for assessment of memory in three steps (acquisition, consolidation and retrieval). Shuttle box trial was used for PA task assessment. Retrieval memory was tested 24h after injection, and the results indicated increased Step Through Latency (STL), showing the enhancement of memory. Moreover, in acute phase of PA, GBP enhanced acquisition and retrieval of memory. In chronic phase of PA, GBP showed no effect on memory. The present study suggests that GBP exerted no destructive effects on cognition; however, it improved emotional cognitive performance in mice in PA tasks.

منابع و مأخذ:

1. Meador K.J., 1996. Cognitive effects of epilepsy and of antiepileptic medications. In: The rreutment of epilepsy: principles and practice. 2nd ed. Williams. B., Eds., Wyllie_ E, ed. Pp. 1121-30.
2. Valley V., Broughton R., 1983. The physiological (EEG) nature of drowsiness it relation to performance deficits in narcoleptics. Electeroencephaloger clin Neurophysiol. 55: 243-51.
3. Reitan R.,Walform D.,1985. The Halsead-Reitan Neurophsiological test Battery. Clinical Neuropsychology Press. 1: 234-250.
4. Arora T., Mehta A.K., Sharma K.K., Mediratta P.K., Banerjee B.D., Garg G.R., Sharma A.K., 2010. Effect of carbamazepine and lamotrigine on cognitive function and oxidative stress in brain during chemical epileptogenesis in rats. Basic Clin Pharmacol Toxicol. 106: 372ââ‚‌“377.
5. Wolf S.M., Shinnar S., Kang H., Gil K.B., Moshe S.L., 1995. Gabapentin toxicity in children manifesting as behavioral changes. Epilepsia. 36: 1203-5
6. Childers M.K., Holland D., 1997. Psychomotor agitation following gabapentin use in brain injury. Brain Inj. 11: 537-40.
7. Jun S., Youqing C., Guoxiang L., Neng G., Zhenze L., Tianle X., Zhugang W., Jian F., 2012. Enhanced learning and memory in GAT1 heterozygous mice. Acta Biochem Biophys Sin. 44: 359ââ‚‌“366.
8. McLean M.J., Gidal B.E., 2003. Gabapentin dosing in the treatment of epilepsy. Clin Ther. 25: 1382ââ‚‌“1406.
9. Rosenberg J.M, Harrell C., Ristic H., Werner R.A., de Rosayro A.M., 1997. The effect of gabapentin on neuropathic pain. Clin J Pain. 13: 251ââ‚‌“255.
10. Young L.T., Robb J.C., Hasey G.M., MacQueen G.M., Patelis Siotis I., Marriott M., Joffe R.T., 1999. Gabapentin as an adjunctive treatment in bipolar disorder. J Affect Disord. 55: 73ââ‚‌“77.
11. Leach J.P., Girvan J., Paul A., Brodie M.J., 1997. Gabapentin and cognition: a double blind, dose ranging, placebo controlled study in refractory epilepsy. J Neurol Neurosurg Psychiatry. 62: 372ââ‚‌“376.
12. Saletu B., Grunberger J., Linzmayer L., 1986. Evaluation of encephalotropic and psychotropic properties of gabapentin in man by pharmaco EEG and psychometry. Int J clin Pharmacol Ther and Toxicol. 24: 362-73.
13. Meador K.J., Loring D.W., Huh K., Gallagher B.B., King D.W., 1990. Comparative cognitive effects of anticonvulsants. Neurology. 40: 391ââ‚‌“394.
14. Salinsky M.C., Binder L.M., Oken B.S., Storzbach D., Aron C.R., Dodrill C.B. 2002. Effects of gabapentin and carbamazepine on the EEG and cognition in healthy volunteers. Epilepsia. 43: 482ââ‚‌“490.
15. Salinsky M.C., Storzbach D., Spencer D.C., Oken B.S., Landry T., Dodrill C.B., 2005. Effects of topir-amate and gabapentin on cognitive abilities in healthy volunteers. Neurology. 64: 792ââ‚‌“798.
16. Yeganeh F., Nikbakht F., Rasouli H. 2011. The effect of acute ethanol and gabapentin administration on spatial learning and memory. Basic and Clinical Neuroscince. 2(2): 44-47.
17. Dimond K.R., Pdnde A.C., Lamoreaux L., Pierce M.W., 1996. Effect of gabapentin (Neurontino) on mood and well-being inpatients with epilepsy. Prog Neuro-psychopharmacol Biol Psychiatry. 20: 407-17.
18. Ogren S.O., Johansson C., Magnusson O., 1985. Forebrain serotonergic involvement in avoidance learning. Neurosci Lett. 58: 305ââ‚‌“309.
19. Ahmadiasl N., Alipour Mohammad R., Andalib S., Ebrahimi H., 2008. Effect of ghee oil on blood fat profile and passive avoidance learning in male rats. Medical Journal of Tabriz University of Medical Sciences. 30(3): 7-10.
20. Ortinski P., Meador K.J., 2004. Cognitive side effects of antiepileptic drugs. Epilepsy Behav. 311: 153ââ‚‌“156.
21. Celikyurt I. K, Mutlu O., Ulak G., Yildiz Akar F., Erden F., 2011. Gabapentin, A GABA analogue, en-hances cognitive performance in mice. Neurosci Lett. 492: 124ââ‚‌“128.
22. Acosta G.B., Boccia M.M., Baratti C.M., 2000. Gabapentin an antiepileptic drug improves memory storage in mice. Neurosci Lett. 279: 173ââ‚‌“176.
23. Blake M.G., Boccia M.M., Acosta G.B., Höcht C., Baratti C.M., 2007. Opposite effects of a single versus repeated doses of gabapentin on retention performance of an inhibitory avoidance response in mice. Neurobiol Learn Mem. 87: 192ââ‚‌“200.
24. Boccia M.M., Acosta G.B., Baratti C.M., 2001. Memory improving actions of gabapentin in mice: possible involvement of central muscarinic cholinergic mechanism. Neurosci Lett. 311: 153ââ‚‌“156.
25. Blake MG., Boccia M.M., Carcaboso A.M., Chiappetta D.A., Höcht C., Krawczyk M.C., Sosnik A., Baratti C.M., 2010. Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice. Epilepsy Behav. 17: 157-64.
26. Löscher W., Hocack D., Taylor C.P., 1991. Gabapentin increases aminooxyacetic acidinduced GABA accumulation in several regions of rat brain. Neurosci Lett 128: 150ââ‚‌“154.
27. McLean M.J., Gidal B.E., 2003. Gabapentin dosing in the treatment of epilepsy. Clin Ther. 25, 1382ââ‚‌“1406.
28. Young L.T., Robb J.C., Hasey G.M., Mac Queen G.M., Patelis Siotis I., Marriott M., Joffe T. 1999. Gabapentin as an adjunctive treatment in bipolar disorder. J Affect Disord. 55: 73ââ‚‌“77.