Investigating the effect of mesenchymal stem cells on airway hyper-responsiveness in asthma
محورهای موضوعی : پزشکی ترمیمی
Kambiz Moghaddasi
1
,
Saeed Hesaraki
2
,
Farnoosh Arfaee
3
,
Seyyed Shamsadin Athari
4
1 - Department of Clinical Sciences, Faculty of Specialized Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Pathobiology, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Clinical Sciences, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 - Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
کلید واژه: Allergy, Cell therapy, Asthma, Lung, Treatment,
چکیده مقاله :
Asthma is a lung disease characterized by eosinophilic inflammation, mucus secretion, airway hyper-responsiveness (AHR), and airway obstruction. AHR is a crucial factor in asthma. Mesenchymal stem cells (MSCs) have a regulatory effect on the immune response and may be useful in treating asthma. MSCs have low immunogenicity and are considered safe for application. Additionally, a study was conducted to investigate the effect of MSCs on controlling AHR in an asthma model. MSCs were isolated and used to treat asthmatic male BALB/c mice. To produce an animal model of asthma, the mice were sensitized and challenged with OVA. On days 30 and 40, to measure AHR, a Methacholine challenge test was performed to determine the Penh value. AHR was recorded and analyzed. Treatment of asthmatic mice with MSCs resulted in a significant difference (p<0.05) in controlling AHR during the MCh challenge test. MSCs are almost non-immunogenic and can be used to treat asthma and control AHR. The use of MSCs as an anti-asthma treatment presents a new and applicable strategy for controlling AHR in asthma.
Asthma is a lung disease characterized by eosinophilic inflammation, mucus secretion, airway hyper-responsiveness (AHR), and airway obstruction. AHR is a crucial factor in asthma. Mesenchymal stem cells (MSCs) have a regulatory effect on the immune response and may be useful in treating asthma. MSCs have low immunogenicity and are considered safe for application. Additionally, a study was conducted to investigate the effect of MSCs on controlling AHR in an asthma model. MSCs were isolated and used to treat asthmatic male BALB/c mice. To produce an animal model of asthma, the mice were sensitized and challenged with OVA. On days 30 and 40, to measure AHR, a Methacholine challenge test was performed to determine the Penh value. AHR was recorded and analyzed. Treatment of asthmatic mice with MSCs resulted in a significant difference (p<0.05) in controlling AHR during the MCh challenge test. MSCs are almost non-immunogenic and can be used to treat asthma and control AHR. The use of MSCs as an anti-asthma treatment presents a new and applicable strategy for controlling AHR in asthma.
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