تهیه، شناسایی و بررسی فعالیت پادباکتری چندسازه های فیبری چندجزئی پلیاکریلونیتریل/چارچوب فلز-آلی نقره/نانوذره های کیتوسان/N-استیل¬سیستیئن
محورهای موضوعی : شیمی معدنیزینب انصاری اصل 1 , حدیث رشیدی کیا 2 , اسماعیل داراب پور 3
1 - دانشیار گروه شیمی، دانشگاه شهید چمران اهواز، اهواز، ایران.
2 - دانشجوی کارشناسی ارشد گروه شیمی، دانشگاه شهید چمران اهواز، اهواز، ایران.
3 - استادیار گروه زیست¬شناسی، دانشگاه شهید چمران اهواز، اهواز، ایران.
کلید واژه: چارچوب فلز-آلی, کیتوسان, N-استیل¬سیستئین, پلی¬اکریلونیتریل, چندسازه, فعالیت پادباکتری.,
چکیده مقاله :
در این کار پژوهشی، چندسازههای فیبری با ویژگی پادباکتری شامل پلیاکریلونیتریل، نانوذرههای کیتوسان (CSNPs)، چارچوب فلز-آلی نقره و N-استیل‌سیستیئن (NAC) بهروش الکتروریسی تهیه شدند. فیبرهای تهیه‌شده با روشهای طیفسنجی فروسرخ تبدیل فوریه (FTIR)، پراش پرتو ایکس (XRD)، میکروسکوپی الکترونی روبشی (SEM) و نگاشت عنصری شناسایی شدند. نتیجههای بهدست‌آمده از بررسی ویژگی پادباکتری ترکیبهای تهیه‌شده در برابر باکتریهای گرم منفی اشریشیا کلی و گرم مثبت استافیلوکوکوس اورئوس نشان داد افزودن چارچوب فلز-آلی نقره و همچنین، ترکیبهای پادباکتری کیتوسان و NAC منجر به بهبود ویژگی پادباکتری فیبرها شدند؛ به‌گونه‌ای‌که نانوفیبر PAN/0.5%Ag-MOF/10%CSNPs/5%NAC بیشترین اثر را در کاهش تعداد سلولهای اشریشیا کلی و استافیلوکوکوس اورئوس نشان داد. ازاین‌رو، می‌توان گفت این ترکیبها قابلیت کاربرد در زمینههای پزشکی مانند استفاده بهعنوان زخمپوش را دارند.
In this research, fibrous composites with antibacterial activities including polyacrylonitrile (PAN), chitosan nanoparticles (CSNPs), silver metal-organic framework, and N-acetylcysteine (NAC) were prepared by electrospinning method. The prepared fibers were studied using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and elemental mapping using energy-dispersive X-ray spectroscopy (EDS). The obtained results of the antibacterial studies against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) showed that the addition of silver metal-organic framework as well as the antibacterial compounds such as CSNPs and NAC led to the improvement of the antibacterial properties of the fibers. Therefore, these compounds have the potential to be used in medical fields such as wound healing
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