Natural Bioactive Products from an Ornamental- Medicinal Flower (Catharanthus roseus (L.) G. Don) forms Promising Therapeutics: A Critical Review of Natural Product-Based Drug Development
محورهای موضوعی : مجله گیاهان زینتی
Somashekara Rajashekara
1
(Centre for Applied Genetics, Department of Studies in Zoology, Bangalore University, Jnana Bharathi Campus, Off Mysuru Road, Bengaluru 560 056, India)
Utpal Baro
2
(Centre for Applied Genetics, Department of Studies in Zoology, Bangalore University, Jnana Bharathi Campus, Off Mysuru Road, Bengaluru 560 056, India)
کلید واژه: Anticancer Activity, antioxidant activity, Antimicrobial Activity, antidiabetic activity, Antileukemia activity, Chemotherapeutic drugs,
چکیده مقاله :
Catharanthus roseus (L.) G. Don (Apocynaceae) commonly called as “flower of immortality”, “the flower of death”, “violet of the sorcerers” and “an emblem of friendship”. It is a well-known weed to employed for treating various disorders. The study aims at far-reaching review on phytochemistry, pharmacological activities, ethnopharmacology, characterization, chemical composition, and biological applications of C. roseus plants which aids to provide scientific evidence for the ethnobotanical claims and to identify gaps required to be conducted as a future research requirement. Most of the traditional and systematic uses obtained from the extraction of C. roseus plants were validated by the scientific studies such as antimicrobial activity, anticancer activity, antidiabetic activity, antileukemia activity, antioxidant activity, chemotherapeutic drugs and therapy, wound healing, production of nanoparticles and nanoproducts, etc. Isolated compounds, mainly terpenoid indole alkaloids (TIA) such as ajmalicine, anhydrovinblastine, catharanthine, serpentine, vindoline, vinblastine, vincristine, and vindolinine were confirmed and showed potent activity. This review article explores the phytochemistry, ethnopharmacological, pharmacological and biological activities of C. roseus plants which gives the evidence of a potent and commercial drug which up on further research leads to the most viable drug for variety of treatments.
پریوش (خانواده خرزهره) معمولا تحت عنوان "گل نامیرا"، "گل مرگ"، "بنفشه جادوگر" و "سمبل دوستی" نامیده می ­شود. این گیاه یک علف هرز شناخته شده در درمان عوارض گوناگون است. از اهداف این مطالعه، دستیابی به کاربردهای فایتوشیمی، فعالیت­ های دارویی، اتنوفارماکولوژی، تشخیص، ترکیبات شیمیایی و زیستی گیاه پریوش است که باعث افزایش مدارک علمی در مورد خواص اتنوبوتانیکی این گیاه شده و به تشخیص خلاءهای موجود کمک کرده و نیازهای تحقیقاتی آینده را مشخص می­ کند. بیشتر استفاده ­های سنتی و سیستمیک که از عصاره این گیاه می­ شود، با مطالعات علمی ضد میکروبی، ضد سرطان، ضد قند خون، ضد سرطان خون، آنتی اکسیدانی، شیمی درمانی، التیام زخم، تولید نانوذرات، محصولات نانو و غیره به تایید رسیده است. محصولات جداسازی و خالص مثل آلکالوئیدهای ایندول ترپنوئیدی (TIA) شامل: آجمالایسین، آنهیدرووینبلاستین، کاتارانتین، سرپنتین، ویندولین، وینبلاستین، وینکریستین و ویندولینین قبلا تهیه، تایید و فعالیت آن­ ها به اثبات رسده است. این مقاله مروری به بررسی فعالیت ­های فایتوشیمیایی،اتنوفارکوماکولوژیکی، فارماکولوژیکی و زیستی گیاه پریوش می­ پردازند که مدرک معتبری در رابطه با داروهای تجاری باشد که با تحقیقات بیشتر بتوان داروهای مناسب­تری برای انواع درمان­ ها تولید کرد.
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