Cell suspension culture of yew: an alternative method of taxol production
محورهای موضوعی : Phytochemistry
1 - the Department of Horticulture, Faculty of Agriculture University of Zanjan, IRAN
کلید واژه: Cell suspension culture, Taxol, Secondary metabolite, Anti-cancer drug, taxus,
چکیده مقاله :
Taxol is one of the most important anti-cancer drugs in the world, which is obtained from the genus of the Taxus. Taxol, with its antimicrobial properties, causes the death of proliferating cells by preventing the formation of abnormally dividing spindles. Abnormal division stops DNA transcription in the G2 / M division of mitosis and thus causes the proliferation of proliferating cells. Due to the low amount of taxol in the tissues of yew and also the very low growth of this plant, meeting the therapeutic need for this drug is the most important issue facing scientists. Commercially, taxol synthesis seems unlikely due to limited resources and the possibility of over-consumption of a natural product that could be found in endangered yew species. Therefore, a suitable alternative method for taxol production should be used. Yew cell suspension culture is one of the most important alternatives for long-term and sustainable production of taxol. This review is about cell suspension culture in different yew species.
Brincat, M. C., D. M. Gibson and M. L. Shuler, 2002. 'Alterations in Taxol production in plant cell culture via manipulation of the phenylalanine ammonia lyase pathway'. Biotechnology Progress, 18, 1149-56.
Bedi, Y., R. Ogra, K. Koul, B. Kaul and R. Kapil, 1996. 'Yew (Taxus spp.) A new look on utilization, cultivation and conservation'. Supplement to cultivation and utilization of medicinal plants. Jammu-Tawi: Regional Research Laboratory.
Bonfill, M., O. Expósito, E. Moyano, R.M. Cusidó, J. Palazón and M.T. Piñol, 2006. 'Manipulation by culture mixing and elicitation of paclitaxel and baccatin III production in Taxus'. In vitro Cellular and Developmental Biology – Plant, 42, 422–426.
Bentebibel. S, E. Moyano, J. Palazon, RM. Cusido, M. Bonfill, R. Eibl, 2005. 'Effects of immobilization by entrapment in alginate and scale-up on paclitaxel and baccatin III production in cell suspension cultures of Taxus baccata'. Biotechnol Bioeng 89:647–55.
Cusido, R. M. Palazon, J. Bonfill, M. Navia-Osorio, A. Morales, C. and Pinol, M. T. 2002. 'Improved paclitaxel and baccatin III production in suspension cultures of Taxus media'. Biotechnology Progress, 18, 418-23.
Cope, EA, 1998. 'Taxaceae: the genera and cultivated species'. Bot Rev. 64(4):291–322.
Croteau, R., REB. Ketchum, RM. Long, R. Kaspera and M. Wildung, 2006. 'Taxol biosynthesis and molecular genetics'. Phytochemistry Reviews 5: 75-97.
Croteau, R., REB. Ketchum, RM. Long, R. Kaspera and M. Wildung, 2006. 'Taxol biosynthesis and molecular genetics'. Phytochemistry Reviews 5: 75-97.
Cardenas-Manríquez, G., I. Vega-Muñoz, A. Villagómez-Aranda, M. León-Galvan, A. CruzHernandez, I. Torres-Pacheco, R. Rangel-Cano, R. Rivera-Bustamante and R. GuevaraGonzalez, 2016. 'Proteomic and metabolomic profiles in transgenic tobacco (N. tabacum xanthi nc) to CchGLP from Capsicum chinense BG-3821 resistant to biotic and abiotic stresses'. Environmental and Experimental Botany. 130, 33–41.
Dornenburg, H. and D. Knorr, 1995. 'Strategies for the improvement of secondary metabolite production in plant cell cultures'. Enzyme and Microbial Technology, 17, 674-684.
Fett-Neto, AG., H. Aoyagi, H. Tanaka and F. Dicosmo, 2004. 'Antitumor agents: Taxol and taxane production by yew cell culture. In RA Myers. Encyclopedia of Molecular Cell Biology and Molecular Medicine'. Wiley-VCH, Weinheim. pp: 415-438
Frense, D., 2007. 'Taxanes: perspectives for biotechnological production'. Appl Microbiol Biot 73:1233–40.
Gandhi, SG., V. Mahajan and YS. Bedi, 2015. 'Changing trends in biotechnology of secondary metabolism in medicinal and aromatic plants'. Planta 241: 303-317.
Holmes, F. A., A.P. Kudelka, J.J.Kavanagh, M . H. Huber, J. A. Ajani and V. Valero, 1995. ' Taxane anticancer agents'. Basic science and current status, (Georg GL, Chen TT, Ojima I, Vyas DM, ed.), PP: 3`-57. American Chimical Society, Washington DC.
Hezari, M., NG. Lewis and R. Croteau, 1995. 'Purification and characterization of taxa- 4(5),11(12)-diene synthase from pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis'. Archives of Biochemistry and Biophysics 322: 437-444.
Hortuwitz, SB, 1992. 'Mechanism of ction of taxol'. Treands. Pharmacol. Sci. 13: 134-136.
Itokawa, H. and K-H. Lee,2002. 'Taxus the genus Taxus'. Taylor and Francis. London and new york.
Itokawa, H. and K. H. Lee, 2003. 'Taxus: The genus of Taxus'. London: Taylor and Francis.
Jordon, M.A. and L. Wilson, 1995. 'Microtubule polymerization dynamics, mitotic block, and cell death by paclitaxel at low concentration'. American Chemical Society Symposium Series, Vol. 583, Chapter X 138 – 153.
Jennewein, S. and R. Croteau, 2001. 'Taxol: biosynthesis, molecular genetics, and biotechnological applications'. Applied Microbiology and Biotechnology, 57, 13-19.
Jennwein, S. and R. Croteau, 2001. 'Taxol: biosynthesis, molecular genetics, and biotechnological applications'. Applied Microbiology and Biotechnology, 57(2-1): 9-13.
Jennewein, S. and R. Croteau, 2001. 'Taxol biosynthesis, molecular genetics and biotechnological applications'. Applied Microbiology and Biotechnology 57(1-2): 9-13
Jha, S., D. Sanyal, B. Ghosh and T. B. Jha, 1998. 'Improved Taxol yield in cell suspension culture of Taxus wallichiana (Himalayan Yew)'. Planta Medica, 64, 270-272.
Ketchum, R. E. B., D. M. Gibson, R. B. Croteau and M. L. Shuler, 1999. 'The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate'. Biotechnology and Bioengineering, 62, 97-105.
Khosroushahi, A. Y., M. Valizadeh, A. Ghasempour, M. Khosrowshahli, H. Naghdibadi, M. R. Dadpour and Y. Omidi, 2006. 'Improved Taxol production by combination of inducing factors in suspension cell culture of Taxus baccata'. Cell Biology International, 30, 262-269.
Kajani, A. A., S. Moghim and M. R. Mofid, 2012. 'Enhanced taxane production and secretion from Taxus baccata cell culture by adding dimethyl sulfoxide'. Biotechnology and Applied Biochemistry. (wileyonlinelibrary.com).
Kolewe, ME., V. Gaurav, SC. Roberts, 2008. 'Pharmaceutically active natural product synthesis and supply via plant cell culture technology'. Mol Pharmaceut, 5:243–56.
Liu, WC., T. Gong and P. Zhu, 2016. 'Advances in exploring alternative Taxol sources'. Royal Society of Chemistry Advances; 6: 48800-48809.
Lee, D-H., S-G. Kim, S. Mun and JH. Kim, 2010. 'Evaluation of feeding and mixing conditions for fractional precipitation of paclitaxel from plant cell cultures'. Process Biochemistry, 45(7), 1134-1140.
Linden, J. C. and M. Phisalaphong, 2000. 'Oligosaccharides potentiate methyl jasmonate induced production of paclitaxel in Taxus canadensis'. Plant Science, 158, 41-51.
Mossadegh, A., 1993. 'Yew tree'. Research Report of University of California, Berkeley.
Mihaljevic, S. and I. Bjedow, 2002. 'Effect of explant source and growth regulators on in vitro callus growth of Taxus baccata L'. washingtonii. Food Technology. Biotechnology, 40(4): 299-303.
Malik, S., R. Cusido , M. Mirjalili , E. Moyano , J. Palazon and M. Bonfil, 2011. 'Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review'. Process Biochem. 46: 23-34.
Mustafa, NR., W. DeWinter, F. VanIren, R. Verpoorte, 2011. 'Initiation, growth and cryopreservation of plant cell suspension cultures'. Nature Protoc 6:715–742
Mejía-Teniente, L., I. Torres-Pacheco, M.M. González-Chavira, R.V. Ocampo-Velazquez, G. Herrera-Ruiz, A.M. Chapa-Oliver and R.G. Guevara-González, 2010. 'Use of elicitors as an approach for sustainable agriculture'. African Journal of Biotechnology. 9, 9155–9162.
Nicolau, K. C., Z. Yang, and J. Liu, 1994. 'Total synthesis of taxol'. Nature Biotechnology, 367(64), 630-634.
Nims, E., C. P. Dubois, S. C. Roberts and R. Walker, 2006. 'Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering'. Meta-engineering, 8:385–394.
Onrubia, M., RM. Cusido, K. Ramirez, L. Hernandez-Vazquez, E. Moyano, M. Bonfill and J. Palazon, 2013. 'Bioprocessing of plant in vitro systems for the mass production of pharmaceutically important metabolites: Paclitaxel and its derivatives'. Current Medicinal Chem. 20: 880-891.
Roberts, SC. and ML. Shuler, 1997. 'Large-scale plant cell culture'. Curr Opin Biotech 8:154–9.
Rao, SR., and GA. Ravishankar, 2002. 'Plant cell cultures: Chemical factories of secondary metabolites'. Biotechnology Advances 20: 101-153.
Shoeb, M., 2006. 'Anticancer agents from medicinal plants'. Bangladesh journal of pharmacology.;1(2):35-41.
Siegel, R. and A. Jemal, 2012. 'Cancer Facts & Figures'. American Cancer Society. 404: 1-64.
Suffness, M. and M.E. Wall, 1995. 'Discovery and development of taxol'. In: Taxol: Science and applications, press, Boca Raton, FL.
Schippmann, U. 2001. 'Medicinal plants significant trade study'. Germany: German Federal Agency for Nature Conservation Bonn.
Stierle, A., G. Strobel, D. Stierle, P. Grothaus and G. Bignami, 1995. 'The search for a taxol-producing microorganism among the endophytic fungi of the pacific yew, Taxus brevifolia'. Journal of Natural Products, 58(9), 1315-1324.
Sabater-Jara, A. B. and M. A. Pedreño, 2013. 'Use of à-cyclodextrins to enhance phytosterol production in cell suspension cultures of carrot (Daucus carota L.)'. Plant Cell Tissue and Organ Culture, 114: 249–58.
Tabata, H., 2004. 'Paclitaxel production by plant-cell-culture technology'. Advances in Biochemical Engineering Biotechnology, 87, 1-23.
Vazquez-Hernandeza, C., A. Feregrino-Perezb, I. Perez-Ramirezc, R.V. Ocampo-Velazqueza, E. Rico-Garcíaa, I. Torres-Pachecoa and R. G. Guevara-Gonzalez, 2019. 'Controlled elicitation increases steviol glycosides (SGs) content and gene expression-associated to biosynthesis of SGs in Stevia rebaudiana B'. cv. Morita II. Industrial Crops & Products, 139: 111479.
Vargas-Hernandez, M., I. Macias-Bobadilla, R.G. Guevara-Gonzalez, Sd.J. Romero-Gomez, E. Rico-Garcia, R.V. Ocampo-Velazquez, Ld.L. Alvarez-Arquieta, and I. TorresPacheco, 2017. 'Plant hormesis management with bio stimulants of biotic origin in agriculture'. Frontiers Plant Sciences. 8, 1762.
Wall, M.E. 1993. 'Campotothein and taxol'. In: Lednicer D., (ed.) Chronicies of Drug Discovery, Washington DC, pp:153-165. American Chemical Society.
Wani, M.C., H.L.Taylor, M.E. wall, P. Coggon and A.T. Mcphail, 1971. 'Plant antitumor agent The isolation and structure of taxol, a novel ant leukemic and antitumor agent from Taxus berevifolia'. Journal of the American Chemical Society, 93: 2325-2327.
Walker, K. and R. Croteau, 2000. 'Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli'. Proceedings of the National Academy of Sciences USA. 97 (2): 583-587.
Walker, K., K. Klettke, T. Akiyama and RB. Croteau, 2004. 'Cloning, heterologous expression, and characterization of a phenylalanine amino mutase involved in Taxol biosynthesis'. Journal of Biological Chem. 279: 53947-54.
Walker, K., S. Fujisaki, R. Long and R. Croteau, 2002. 'Molecular cloning and heterologous expression of the C-13 phenylpropanoid side Chain-CoA acyltransferase that functions in Taxol biosynthesis'. Proceedings of the National Academy of Sciences USA 99 (20): 12715-12720.
Walker, K., R. Long and R. Croteau, 2002. 'The final acylation step in Taxol biosynthesis: cloning of the taxoid C13-side-chain N-benzoyltransferase from Taxus'. Proceedings of the National Academy of Sciences USA 99: 9166-71.
Zhong, J., 2002. 'Plant cell culture for production of paclitaxel and other taxanes'. Journal of Bioscience and Bioengineering, 94(6), 591-599.
Zhang, C. H., J. Y. Wu and G. Y. He, 2002. 'Effects of inoculum size and age on biomass growth and paclitaxel production of elicitor-treated Taxus yunnanensis cell cultures'. Applied Microbiology and Biotechnology, 60, 396-402.
Zhang, C. H. and J. Y. Wu, 2003. 'Ethylene inhibitors enhance elicitor-induced paclitaxel production in suspension cultures of Taxus spp. cells. Enzyme and Microbial Technology, 32, 71-77.
Zhang, C. H., X. G. Mei, L. Liu and L. J. Yu, 2000. 'Enhanced paclitaxel production induced by the combination of elicitors in cell suspension cultures of Taxus chinensis'. Biotechnology Letters, 22: 1561–156
