Impact of Reactive Oxygen Species on Spermatozoa: ABalancing Act between Beneficial and Detrimental Effects

محورهای موضوعی : Camel

اس. ساراسوات ¹ ( Male Reproduction Laboratory, PRSM Division,Central Institute for Research on Goats, Makhdoom,Farah, Mathura, 281122, India )
اس.دی. خرچه ² ( Male Reproduction Laboratory, PRSM Division,Central Institute for Research on Goats, Makhdoom,Farah, Mathura, 281122, India )
اس.کا. جینتا ³ ( Male Reproduction Laboratory, PRSM Division,Central Institute for Research on Goats, Makhdoom,Farah, Mathura, 281122, India )

تاریخ دریافت : 1391/11/01 تاریخ پذیرش : 1391/12/26 تاریخ انتشار : 1392/12/10

کلید واژه: Semen, reactive oxygen species,

چکیده مقاله :

Reactive oxygen species (ROS)plays an important role in sperm motility. The physiological generation at low concentration induces beneficial effects on sperm functions and plays a significant role in sperm metabolism. Meanwhile, the excessive generation of reactive oxygen species can overwhelm protective mechanism and triggers changes in lipid and protein layers of sperm plasma membrane, which induces lipid damage, protein damage, DNA damage, motility impairment and alteration in capacitation and acrosome reaction. Reactive oxygen species (ROS) can be measured by variable biomarkers as melondialdehyde (MDA) concentration, individual free radicals, etc. The quantification of free radicalsin livestock semen is also briefly reported.

چکیده انگلیسی:

گونه­های اکسیژن فعال (ROS) نقش مهمی در تحرک اسپرم دارند. تولید فیزیولوژیکی آن‌ها در غلظت­های پایین سبب القای آثار سودمند بر عملکرد اسپرم شده و نقش مهمی در سوخت و ساز اسپرم ایفا می­نمایند. در ضمن، تولید بیش از حد گونه­های اکسیژن فعال می­تواند مکانیسم حفاظتی را خنثی نموده و سبب بروز تغییراتی در لایه­های چربی و پروتئینی غشای پلاسمایی اسپرم شود. این امر سبب ایجاد آسیب در چربی، پروتئین و DNA شده و باعث ایجاد اختلال در تحرک اسپرم و تغییر در ظرفیت­پذیری و واکنش آکروزومی می­شود. گونه­های اکسیژن فعال (ROS) می­توانند به وسیله نشانگرهای زیستی مختلفی نظیر غلظت مالون دی آلدئید، رادیکال­های آزاد منفرد و غیره اندازه­گیری شوند. شیوه‌ی تعیین کمّی رادیکال­های آزاد در منی حیوانات مزرعه­ای نیز به اختصار گزارش می­شود.

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