The Effect of Curcumin on Acetaminophen-Induced Toxicity on Performance and some Blood Parameters of Japanese Quail from 0-37 Days of Age
محورهای موضوعی : CamelM. Emadi 1 , A. Hadavi 2 , J. Ameri 3 , H. Kermanshahi 4
1 - Department of Animal Science, Facultyof Agriculture,Payame Noor University, Tehran, Iran
2 - Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
3 - Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
4 - Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran
کلید واژه: Performance, quail, Acetaminophen, Curcumin, liver,
چکیده مقاله :
This study was conducted to determine the effects of supplemented curcumin (CMN), derived from plant Curcuma longa, extract on performance and blood parameters of acetaminophen (ACT) induced quail hepatic injury. 240 quails from 0-37 days of age were used in a completely randomized design with 4 treatments of 4 replicates each and 15 chickens per replicate. All groups received 750 mg/kg body weight oral doses of ACT at 12 days of age. Japanese quails were divided into four groups: control (no CMN), commercial diet with 20 g CMN per ton, commercial diet with 40 g CMN per ton and commercial diet with 60 g CMN per ton. Feed intake and body weight gain were recorded weekly. Blood albumin, glucose, total protein, triglyceride, aspartate aminotransferase, alanine aminotransferase, bilirubin, uric acid and creatinine were determined at 28 and 35 days of age. Adding curcumin to the diets significantly increased serum aspartate aminotransferase at 28 days of age (P<0.05) and decreased triglyceride and bilirubin at 35 days of age (P<0.05). There were no significant differences in performance and other blood parameters among the treatment groups at 28 and 35 days of age. The data indicated that curcumin is a natural antioxidant hepatoprotective agent against hepatotoxicity induced by acetaminophen model. Thus, curcumin may have a therapeutic value in drug-induced hepatotoxicity as well as in acetaminophen therapy.
به منظور بررسی اثر کورکومین "استخراج شده از گیاه زردچوبه" بر شاخص‌های عملکرد و فراسنجه‌های خونی بلدرچین ژاپنی که متأثر از آسیب کبدی ناشی از استامینوفن بودند آزمایشی صورت گرفت. اعمال چهار تیمار با چهار تکرار با استفاده از 240 قطعه بلدرچین از روز اول شروع و برای یک دوره 37 روزه در 16 پن صورت گرفت. تیمارهای استفاده شده شامل: کنترل (بدون کورکومین)، جیره تجاری همراه با 20 گرم کورکومین در تن، جیره تجاری همراه با 40 گرم کورکومین در تن و جیره تجاری همراه با 60 گرم کورکومین در تن بودند. تمام تیمارها میزان 750 میلی‌گرم در کیلوگرم وزن بدن استامینوفن در 12 روزگی دریافت کردند. مصرف خوراک و اضافه وزن بدن در طول مدت آزمایش به صورت هفتگی اندازه‌گیری شده و مورد تجزیه و تحلیل آماری قرار گرفتند. برای اندازه‌گیری فراسنجه‌های خونی (آلبومین، گلوکز، پروتئین کل، تری گلیسیرید، آسپارتات آمینوترانسفراز، آلانین آمینوترانسفراز، بیلی روبین، اسید اوریک و کراتینین) خون‌گیری در روزهای 28 و 35 روزگی انجام شد. افزودن کورکومین به جیره مقدار آسپارتات آمینوترانسفراز سرم را در 28 روزگی افزایش داد و همچنین مقدار تری گلیسیرید و بیلی روبین را در 37 روزگی کاهش داد (05/0P<). این داده‌ها می‌توانند نشان دهند که کورکومین آنتی اکسیدانی طبیعی برای محافظت از کبد است هنگامی که آسیب کبدی ناشی از استامینوفن روی دهد. بنابراین به نظر می‌رسد کورکومین در درمان آسیب‌های ناشی از استامینوفن ارزش برابری با داروهای محافظت‌کننده از کبد داشته باشد.
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