Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities
محورهای موضوعی : Iranian Journal of Catalysis
Ayoob Bazgir
1
(Department of Chemistry, Shahid Beheshti University, P.O. Box 1983963113, Tehran, Iran.)
Seyyedeh Cobra Azimi
2
(Young Researchers Club, Rasht Branch, Islamic Azad University, Rasht, Iran)
کلید واژه: Ionic Liquid, Pyrimido[4, 5-d]pyrimidine-2, 4-dione, 6-Amino-uracil, Antibacterial activities,
چکیده مقاله :
A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity, simple workup and reusability of ionic liquid. These products were evaluated in vitro for their antibacterial activities.
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