Preparation and characterization of a dual acidic Ionic Liquid functionalized Graphene Oxide nanosheets as a Heterogeneous Catalyst for the Synthesis of pyrimido[4,5-b] quinolines in water
محورهای موضوعی : Iranian Journal of Catalysis
Mohanad Saleh
1
,
Ghufran Sadeek
2
,
Shakir Saied
3
1 - Department of Chemistry, College of Education for pure Science, Mosul University, Ministry of High Education and Scientific Research, Mosul, Iraq
2 - Department of Chemistry, College of Education for pure Science, Mosul University, Ministry of High Education and Scientific Research, Mosul, Iraq
3 - Department of Medical Laboratory Techniques, Al-Noor University College, Iraq
کلید واژه: Ionic liquid, Graphene oxide, Reusability, Green catalyst, pyrimido[4, 5-b]quinolones,
چکیده مقاله :
Pyrimido[4,5-b]quinolones play a significant role in medicinal chemistry owing to their various biological properties, including antihistaminic, antimalarial, antifungal, anticancer, antioxidant, antiviral, anti-microbial, and anti-inflammatory activities. A dual acidic ionic liquid anchored on graphene oxide nanosheets (GO-Si-Pr-Lysin-SO3H) was provided and characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR). The six-step process was utilized to create this catalyst, beginning with graphite powder. This catalyst was capable to develop the one-pot and three components (6-amino-1,3-dimethyluracil, dimedone, and different aromatic aldehydes) synthesis of pyrimido[4,5-b]quinolone derivatives at moderate temperature in water as a green medium (12 derivatives). The results obtained indicated that this method could be an effective approach for synthesizing pyrimido[4,5-b]quinolones with high yields ranging from 86% to 98% in a short reaction time of 15 to 40 minutes. In addition, the pointed catalyst shows reusability and recoverability without remarkable loss of catalytic activity.
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