Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions

محورهای موضوعی : Iranian Journal of Catalysis

Farzaneh Mohamad Pour ¹ (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran.)
Malek Taher Maghsoodlou ² (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran.)
Reza Heydari ³ (Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran.)
Mojtaba Lashkari ⁴ (Faculty of Science, Velayat University, Iranshahr, Iran.)

تاریخ دریافت : 1394/05/16 تاریخ پذیرش : 1394/10/12 تاریخ انتشار : 1395/03/12

کلید واژه: 3, Biginelli reaction, Oxalic acid.2H2O, Green methodology, 4-Dihydropyrimidinone,

چکیده مقاله :

Oxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is studied. The most remarkable benefits of this synthetic method include the green methodology, an eco-friendly, inexpensive and non-toxic catalyst, solvent-free conditions, the availability of materials, and a simple operational procedure with no column chromatographic separation. The products were characterized by melting points, IR and 1H NMR spectroscopy.

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