Synthesis of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates using nanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst
محورهای موضوعی : Iranian Journal of CatalysisJavad Safaei-Ghomi 1 , Mehrnoosh Asgari-Kheirabadi 2 , Hossein Shahbazi-Alvi 3 , Abolfazl Ziarati 4
1 - Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran.
2 - Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran.
3 - Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran.
4 - School of Chemistry, College of Science, University of Tehran, Tehran 14155-6455, Iran.
کلید واژه: One-pot, Multicomponent reaction, Catalytic activity, 3-c]pyrazole, Nano-ZnZr4(PO4)6, Pyrano[2,
چکیده مقاله :
Nanocrystalline ZnZr4(PO4)6 ceramics as an efficient catalyst have been used for the preparation of methyl 6-amino-5-cyano-4-aryl-2,4-dihydropyrano[2,3-c]pyrazole-3-carboxylates by the four component reaction of dimethylacetylenedicarboxylate, hydrazinehydrate, malononitrile and aromatic aldehydes in water at room temperature. In this research Nano-ZnZr4(PO4)6 coordinate with the active groups(particular C=O, C≡N and active H) thus increasing the activity of the groups. Also this nanoscale heterogeneous catalysts present higher surface areas which are mainly responsible for their catalytic activity. These surface atoms behave as the centers where the chemical reactions could be catalytically activated. The key advantages of this process are high yields, shorter reaction times, reusability of catalyst, easy work-up, milder reaction conditions and environmentally benign.
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