One-pot pseudo-five-component synthesis of dihydropyrano[2,3-g] chromenes using sodium phthalimide/[BMIM]BF4 as high efficient catalytic system
محورهای موضوعی : Iranian Journal of CatalysisLeila Moradi 1 , Maryam Aghamohammad Sadegh 2
1 - Department of Organic Chemistry, Faculty of Chemisry, University of Kashan, Kashan, Iran, P.O. Box 8731753153.
2 - Department of Organic Chemistry, Faculty of Chemisry, University of Kashan, Kashan, Iran, P.O. Box 8731753153.
کلید واژه: One-pot synthesis, Multicomponent reaction, Heterocycles, Dihydropyrano[2, 3-g] chromenes, [BMIM]BF4, Sodium phthalimide,
چکیده مقاله :
An efficient route for the synthesis of dihydropyrano[2,3-g] chromenes via one-pot pseudo-five component cyclization reaction of an aldehyde, malononitrile and 2,5-dihydroxy-1,4-benzoquinone in the presence of an effective and mild catalytic system containing sodium phthalimide and 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) ionic liquid (SPI/IL) was studied. The reaction products were characterized using 1H NMR, 13C NMR, FTIR, Mass spectroscopy and elemental analysis. Environmentally eco-friendly catalyst, clean reaction with easy work-up (through simple filtration) and high yield products with no more purification are the main merits of this protocol. Presented method can be used for the synthesis of mentioned products (with pharmacology and Biologic properties) in large scales.
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