Antimalarial activities of Breynia Nivosa
محورهای موضوعی : مجله گیاهان داروییجود اکوکون 1 , کوفرش داویس 2 , آزار ب.آ 3
1 - گروه فارماکولوژی و سم شناسی، دانشکده داروسازی، دانشگاه Uyo، Uyo، نیجریه.
2 - گروه فیزیولوژی، دانشکده علوم پزشکی، دانشگاه Uyo، Uyo، نیجریه.
3 - گروه علوم زیستی، دانشگاه ابوجا، نیجریه.
کلید واژه: Antiplasmodial, Breynia nivosa, Antimalarial, herbal remedy,
چکیده مقاله :
Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosawas evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosawas investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control control (p Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.
Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control control (p Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.
Amadi, E.S., Oveka, C.A., Onveagba, R.A., Ugbogu, O.C., Okoli, I. 2007. Antimicrobial screening of Breynia nivosus and Ageratum conzynoides against dental caries organisms. Journal of Biological Sciences., 7(2): 354 -358.
Christensen, S. B., Kharazmi, A. 2001. Antimalarial natural products. Isolation, characterization and biological properties. In. Bioactive compounds from natural sources: Isolation, characterization and biological properties. Ed. Tringali, C. London, Taylor & Francis. Pp.379- 432.
Homburger, F. 1989. In vivo testing in the study of toxicity and safety evaluation. In: A guide to general toxicology. Marquis J. K . (Ed). 2nd Edn Karger, New York
Kirby, G. C.,O’Neill, M. J., Phillipson, J. D., Warhurst, D. C. 1989. In vitro studies on the mode of action of quassinoids with against chloroquine resistant Plasmodium falciparum. Biochemical Pharmacology., 38: 4367- 4374.
Knight, D. J., Peters, W. 1980. The antimalarial action of N- Benzyloxydihydrotriazines and the studies on its mode of action. Annals of Tropical Medicine and Parasitology., 74,393 -404.
Liao, Y.F., Kupchan, S. M., Horwitz, S. B. 1976. Mode of action of antitumour compound bruceantin, an inhibitor of protein synthesis. Molecular Pharmacology., 12: 167 – 176.
Lorke, D. 1983. A New Approach to Practical Acute Toxicity Testing. Archieves of Toxicology., 54: 275-286.
Lui, K. C., Yang, S. C., Roberts, M. F. 1992. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plants Cell II., 637 - 640.
Odetola, A., Basir, O. 1980. Evaluation of Antimalarial properties of some Nigerian Medicinal Plants. In: Sofowora A, Editor. Proceeding of African Bioscience Network, Federal Ministry of Science and Technology, Nigerian Society of Pharmacology and Drug Research and Production unit, University of Ife organized Workshop, Ife. pp. 275 – 283.
Onyegbule, F.A., Ilouno, I.O., Ikeh, C., Umeokoli, B.O., Eze, P.M. 2014. Evaluation of phytochemical constituents, analgesic, anti-inflammatory, antimicrobial and antioxidant activities of extracts of Breynia nivosa leaves. Planta Med., 80 - LP18. DOI: 10. 1055/s-0034-1395078
Peters, W. 1965. Drug Resistance in Plasmodium berghei. Experimental Parasitology., 17, 80-89.
Philipson, J. D., Wright C. W. 1991. Antiprotozoal compounds from plants sources. Planta Medica., 57: 553-559.
Retnam K. R., DeBritto A. J. 1988. Preliminary phytochemical screening of three medicinal plants of tirunelveli hills. Journal of Economy Texas Botany., 22: 42.
Ryley, J.F., Peters, W. 1970. The antimalarial activity of some quinolone esters. Annals of Tropical Medicine and Parasitology.,84: 209-222.
Smith A C. 1981. Flora Vitiensis nova: a new flora of Fiji. National Tropical Botanical Garden, Lawai, Kauai, Hawaii., 2: 466-467.
