Effect of diluents on the compaction and compressional characteristics of the stem bark extract of Terminalia avicennoides

محورهای موضوعی : مجله گیاهان دارویی

جانسون ایساک ¹ , اولوبونمی اولایمی ² , کوکونه ایکره ³ , رشیدا عبدالهی ⁴ , یوهانس اوبوغاره ⁵ , جودیت جان ⁶ , ابراهیم مهدی ⁷ , کریستیانا ایسیمی ⁸

1 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛
2 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛
3 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛
4 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛
5 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛
6 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛
7 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛
8 - بخش فناوری دارویی و توسعه مواد خام، موسسه ملی تحقیقات و توسعه دارویی (NIPRD)، منطقه کاداستر، نیجریه؛

تاریخ دریافت : 1400/07/03 تاریخ پذیرش : 1400/10/19 تاریخ انتشار : 1400/10/01

کلید واژه: stem bark extract, Tablets, Terminalia avicennoides, Diluents, Heckel, Kawakita,

چکیده مقاله :

Background & Aim: Herbal medicines have historical use and is currently being used in treatment of various diseases largely due to its relative availability and cheap cost. Standardization and development of suitable dosage forms for herbal medicines is therefore pertinent for both practitioners and patients. This study aims to evaluate effect of diluents (microcrystalline cellulose, lactose and magnesium carbonate) on the compaction and compression properties of the stem bark extract of Terminalia avicennoides.Experimental: The crushed powdered stem bark was macerated in 70 % ethanol for 72 h at room temperature with intermittent stirring. The filtrate was concentrated over a water bath at 100 °C to obtain the dried extract (TAE). Granules of the extract were prepared by wet granulation. Flow properties and moisture content of the granules were determined. Compatibility between the extract and the diluents was investigated by Fourier Transform Infrared (FTIR). Compacts were made and properties evaluated using the Heckel and Kawakita models.Results: Results of FTIR spectra showed no interaction between the ingredients of the tablet formulations. Granules prepared with microcrystalline cellulose (T-MCC) possessed better flow and showed more propensities to be compacted than the other tablet batches. All the tablet formulations were observed to exhibit plastic deformation but T-MCC showed faster onset of deformation, closer packing, less cohesiveness, greater densification and easier compaction ability than tablets prepared with lactose (T-LAC) and magnesium carbonate (T-MAG). Although T-MAG showed the highest tensile strength, it was the only formulation that disintegrated within the 30 min official specification for herbal tablets.Recommended applications/industries: However, based on other parameters apart from disintegration time, microcrystalline cellulose is considered as the diluent of choice for preparation of standardized and robust tablets of stem bark extract of Terminalia avicennoides.

چکیده انگلیسی:

Background & Aim: Herbal medicines have historical use and is currently being used in treatment of various diseases largely due to its relative availability and cheap cost. Standardization and development of suitable dosage forms for herbal medicines is therefore pertinent for both practitioners and patients. This study aims to evaluate effect of diluents (microcrystalline cellulose, lactose and magnesium carbonate) on the compaction and compression properties of the stem bark extract of Terminalia avicennoides.Experimental: The crushed powdered stem bark was macerated in 70 % ethanol for 72 h at room temperature with intermittent stirring. The filtrate was concentrated over a water bath at 100 °C to obtain the dried extract (TAE). Granules of the extract were prepared by wet granulation. Flow properties and moisture content of the granules were determined. Compatibility between the extract and the diluents was investigated by Fourier Transform Infrared (FTIR). Compacts were made and properties evaluated using the Heckel and Kawakita models.Results: Results of FTIR spectra showed no interaction between the ingredients of the tablet formulations. Granules prepared with microcrystalline cellulose (T-MCC) possessed better flow and showed more propensities to be compacted than the other tablet batches. All the tablet formulations were observed to exhibit plastic deformation but T-MCC showed faster onset of deformation, closer packing, less cohesiveness, greater densification and easier compaction ability than tablets prepared with lactose (T-LAC) and magnesium carbonate (T-MAG). Although T-MAG showed the highest tensile strength, it was the only formulation that disintegrated within the 30 min official specification for herbal tablets.Recommended applications/industries: However, based on other parameters apart from disintegration time, microcrystalline cellulose is considered as the diluent of choice for preparation of standardized and robust tablets of stem bark extract of Terminalia avicennoides.

منابع و مأخذ:

Adane, M., Endale, A., Bultosa, G., Gamal, M.A. and Gebre-Mariam, T. 2006. Isolation and  physicochemical characterization of godare (Colocasia esculenta) starch from Ethiopia. Ethiopian Pharmaceutical Journal, 24: 13–22.

Adedokun, M.O., Ayorinde, J.O. and Odeniyi, M.A. 2014. Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations. Current Issues in Pharmacy and Medical Sciences, 27(3): 187–194.

Adeleye, O.A., Femi-Oyewo, M.N. and Odeniyi, M.A. 2015. Effect of compression pressure on mechanical and release properties of tramadol matrix tablets. Current Issues in Pharmacy and Medical Sciences, 28(2): 120–125.

Adetunji, O.A., Odeniyi, M.A. and Itiola, O.A. 2006. Compression, mechanical and release properties of chloroquine phosphate tablets containing corn and trifoliate yam starches as binders. Tropical Journal of Pharmaceutical Research, 5(2):589–596.

Afolabi, O., Akanbi, O.M. and Bakare, O.S. 2019. Effects of powdered stem bark of Terminalia avicennioides made as dietary feed fed to mice infected with Plasmodium berghei, on liver function. Asian Journal of Biochemistry, Genetics and Molecular Biology, 2(4): 1–11.

Akanbi, O.M., Elekofehinti, O., Olatokunbo, A., Adejuyigbe, A. and Jegede, A. 2018. Anti-malarial activity of total saponins from Terminalia avicenniodes and its effects on liver and hematological of infected mice. Drug Design, 7(2):1–6.

Akanbi, OM., Saliu, J.A., Adejuyigbe, A., Adefala, T., Goodluck, A. and Adedoyin, D. 2017. Combination therapy of methanolic leaf extracts of Anogeissus leiocarpus and Terminalia avicennioides on malaria parasite count and its effect on some biochemical parameters in mice infected with plasmodium berghei. International Journal of Tropical Diseases & Health, 25(2):1–9.

Alebiowu, G. and Itiola, O.A. 2002. Compressional characteristics of native and pregelatinized forms of sorghum,   plantain,   and   corn   starches   and   the mechanical properties of their tablets compressional characteristics of native and pregelatinized forms of sorghum, plantain, and corn starch. Drug Development and Industrial Pharmacy, 28(6): 663–672.

Ansel, H.C. and Loyd, V. 2011. Ansel’s Pharmaceutical Dosage  Forms  and  Drug  Delivery Systems. 10^th ed. Walters Kluwer.

Archer, M., Kumadoh, D., Naana, G., Odoi, M., Kofi, E., Antwi, S. and Ampomah, A. 2020. Formulation and evaluation of capsules containing extracts of Cassia sieberiana for improved therapeutic outcome. Scientific African, 10:e00609.

Chattoraj, S. and Sun, C.C. 2018. Crystal and particle engineering strategies for improving powder compression and flow properties to enable continuous tablet manufacturing by direct compression. Journal of Pharmaceutical Sciences, 3:1–7.

Desai1, A.R., Hiremath, S.V., Halakatti, P.K. and Srinivas, Y. 2020. Formulation and evaluation of herbal anti-inflammatory gel containg Daucus Carota Linn extract.World Journal of Pharmacy and Pharmaceutical Sciences, 9(11): 1570–1590.

Emeje, M., Christianah, I., Amaka, I. and Olubunmi, O. 2017. Effects of some channelling agents on the compaction properties of the mixed stem bark extracts of Anogeissus leiocarpus and Prosopis africana. Journal of Herbal Drugs, 8(1): 9–14.

Emeje, M.O., Isimi, C.Y., Oqua, D.A. and Kunle, O.O. 2005. Some compaction characteristics of the hot water leaf extract of Nauclea latifiola: A potential antimalarial agent. Journal of Herbal Pharmacotherapy, 5(4):23–30.

Geldart, D., Abdullah, E.C., Hassanpour, A., Nwoke, L.C. and Wouters, I. 2006. Characterization of powder flowability using measurement of angle of repose related papers. China Particuology, 4(3):104–107.

Iyiola, O.A., Tijani, A.Y. and Lateef, K.M. 2020. Antimalarial activity of ethanolic stem bark extract of Alstonia boonei in mice. Asian Journal of Biological Sciences, 4(3): 235–243.

Kaur, M., Oberoi, D.P.S., Sogi, D.S. and Gill, B.S. 2011. Physicochemical , morphological and pasting properties of acid treated starches from different botanical sources, Journal of Food Science and Technology, 48(4): 460–465.

Lai, Z.Y., Chua, H.B. and Goh, S.M. 2013. Influence of process parameters on the strength of oil palm kernel shell pellets, Journal of Material Science, 48: 1448–1456.

Mahours, G.M., Shaaban, D.E.Z., Shazly, G.A. and Auda, S.H. 2017. The effect of binder concentration and dry mixing time on granules, tablet characteristics and content uniformity of low dose drug in high shear wet granulation. Journal of Drug Delivery Science and Technology, 17: 1–23.

Nwaorgu, O.C. and Orajaka, B.N. 2011. Prevalence of malaria among children 1–10 years old in communities in Awka north local government area, Anambra State South East Nigeria. African Research Review, 5(22): 1–10.

Omonkhua, A.A., Cyril-olutayo, M.C., Akanbi, O.M. and Adebayo, O.A. 2013. Antimalarial, hematological, and antioxidant effects of methanolic extract of Terminalia avicennioides in Plasmodium berghei -infected mice. Parasitology Research, 1:1-7.

Osamura, T., Takeuchi, Y., Onodera, R., Kitamura, M., Takahashi, Y., Tahara, K. and Takeuchi, H. 2018. Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures. Asian Journal of Pharmaceutical Sciences, 13(2):113–119.

Panda, D.S., Choudhury, N.S.K., Yedukondalu, M., Si, S. and Gupta, R. 2018. Evaluation of gum of Moringa oleifera as a binder and release retardant in tablet formulation. Indian Journal of Pharmaceutical Sciences, 1(5): 1–5.

Patil, S.G., Jadhav, V.M. and Kadam, V.J. 2012. Formulation and evaluation of herbal gel. Indian Journal of Natural Products and Resources, 3(4): 501–505.

Pongpiachan, S. 2014. FTIR spectra of organic functional group compositions in PM collected at Chiang-Mai city, Thailand during the haze episode in march 2012. Journal of Applied Sciences, 14(22):2967–2977.

Shuaibu, M.N., Wuyep, P.A., Yanagi, T. and Hirayama, K. 2008. The use of microfluorometric method for activity-guided isolation of antiplasmodial compound from plant extracts. Parasitology Research, 102:1119–1127.

Sun, C.C. and Himmelspach, M.W. 2006. Reduced tabletability of roller compacted granules as a result of granule size enlargement. Journal of Pharmaceutical Sciences, 95(1): 200–206.

Virtanen, S., Antikainen, O., Raikkonen, H. and Ylirusi, J. 2010. Granule size distribution of tablets. Journal of Pharmaceutical Sciences, 99(4): 14–17.

WHO. 2015. Guidelines for the Treatment of Malaria. In World Health Organization (WHO).