Antiulcerogenic activity of stem extract and fractions of Homalium Letestui
محورهای موضوعی : مجله گیاهان داروییلوییس آمازو 1 , جواد اکوکون 2 , لوکی نوییدا 3
1 - Department of Pharmacology and Therapeutics, College of Medicine,Evans Enwerem University, Orlu Campus, Imo State
2 - Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
3 - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State
کلید واژه: Homalium letestui, Gastric protective, Antiulcer,
چکیده مقاله :
Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties. Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models. Results & Discussion: The extract (200 – 600 mg/kg) inhibited ethanol, indomethacin, reserpine and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001). The effects of the extract/fraction were comparable to that of the standard drugs used in indomethacin and ethanol-induced ulcer models with the dichloromethane fraction having the highest activity. Industrial and practical recommendations: The present study demonstrates that stem extract of Homalium letestui might to be useful for the treatment of ulcer.
مقدمه و هدف: Homalium letestui که به طور سنتی توسط مردم ایبی بیو در جنوب نیجریه برای درمان زخم معده، مالاریا و سایر بیماریها استفاده می شود جهت بررسی ویژگیهای ممانعت کنندگی از ایجاد زخم معده مورد مطالعه قرار گرفت. روش تحقیق: تاثیر عصاره اتانولی ساقه (600-200 میلی گرم در کیلوگرم) و فراکشنها (آبی و دی کلرومتان؛ 400 میلی گرم در کیلوگرم) در زخم القا شده در شرایط آزمایشگاهی مورد مطالعه قرار گرفت. نتایج و بحث: عصاره (600-200 میلی گرم در کیلوگرم) از ایجاد زخم القا شده در مدلهای اتانول، ایندومتاسین، رزرپین و هیستامین به صورت وابسته به دوز ممانعت کرد و درجات ممانعت کنندگی از نظرآماری (p<0.05, 0.01, 0.001) معنی دار بودند. تاثیر عصاره قابل مقایسه با داروهای استاندارد مورد استفاده در مدلهای زخم القا شده توسط ایندومتاسین و اتانول بود و فراکشنهای به دست آمده توسط دی کلرومتان بیشترین فعالیت را داشتند. توصیه های کاربردی/صنعتی: این تحقیق نشان داد که عصاره ساقه Homalium letestui می تواند در درمان زخم موثر باشد.
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