Effect of the essential oil of thyme on intestinal morphology in Rat
محورهای موضوعی : مجله گیاهان دارویی
حشمت سپهری مقدم
1
(گروه کشاورزی، دانشگاه پیام نور تهران، تهران، ایران)
مژده عمادی
2
(گروه کشاورزی، دانشگاه پیام نور تهران، تهران، ایران)
الهام ملاشاهی
3
(گروه کشاورزی، دانشگاه پیام نور تهران، تهران، ایران)
کلید واژه: Small intestine, volatile oil, Indomethacin, Thymus vuglaris,
چکیده مقاله :
Background & Aim: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical medicine. The adverse effects they produce in the gastrointestinal tract however, often limit their utility. Oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. In view of this, the effect of thyme essential oil, an agent with anti-oxidant properties, was evaluated on indomethacin-induced small intestinal damage in a rat model. Experimental: The chemical composition of thyme essential oil was identified by gas chromatography mass spectrometry. Tissues morphology affected by indomethacin, with and without treatment with thyme, was measured. Results & Discussion: The small intestine morphology (villus height, villus width, and crypt depth and crypt width of duodenum, jejunum and ilea) from indomethacin-treated animals with thyme oil was significantly improved than those from indomethacin animals. Treatment with thyme oil was found to ameliorate these drug-induced changes. Recommended applications/industries: The essential oil of thyme appears to hold promise as an agent that can potentially reduce non-steroidal anti-inflammatory drugs induced small intestinal damage.
مقدمه و هدف: داروهای ضدالتهاب غیراستروئیدی در پزشکی بالینی استفاده می شوند. اگرچهگاهی اثرات خاصی در دستگاه گوارش ایجاد می­نمایند. استفاده خوراکی داروی ایندومتاسین باعث بروز استرس اکسیداتیو در روده کوچک می­شود. روش تحقیق: تاثیر آویشن که دارای خصوصیات آنتی­اکسیدانی است بر موش­هائی که با ایندومتاسین تغذیه اجباری شده­بودند, بررسی شد.مواد موثره آویشن از طریق اسپکتوفتومتری گاز کروماتوگرافی تعیین شد. نتایج و بحث: ارتفاع پرز, عرض پرز, ارتفاع کریپت و عرض کریپت در دئودنوم, ژژنوم و ایلئوم موش­­های تغذیه شده با ایندومتاسین و تیمار شده با آویشن در مقایسه با موش­های تغذیه شده با ایندومتاسین بهبود معنی­داری نشان داد. توصیه کاربردی/ صنعتی: تیمول حاصل از انسانس آویشن به عنوان ماده ای موثر در جهت کاهش اثرات زیانبار داروی ایندومتاسین توصیه می­شود.
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