Black seeds (Nigella sativa) for the management of dengue viral disease: insight into the evidence and POM analyses for the identification of antiviral pharmacophore sites: a review

محورهای موضوعی : مجله گیاهان دارویی

Naina Mohamed Pakkir Maideen ¹ , Taibi Ben Hadda ² , Faisal Almalki ³ , Hamid Laarousi ⁴ , Sameh Soliman ⁵ , Sarkar Kawsar ⁶

1 - Pharmacologist, Dubai Health Authority, Dubai, UAE;
2 - Umm Al-Qura University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Makkah Almukkarramah 21955, Saudi Arabia;
3 - Umm Al-Qura University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Makkah Almukkarramah 21955, Saudi Arabia;
4 - Mohammed Premier University, Faculty of Science, Laboratory of Applied Chemistry & Environment, BP 524, Oujda 60000 , Morocco;
5 - Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates;
6 - Laboratory of Carbohydrate and Nucleoside Chemistry, Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong-4331, Bangladesh;

تاریخ دریافت : 1401/07/28 تاریخ پذیرش : 1401/12/06 تاریخ انتشار : 1402/03/01

کلید واژه: Nigella sativa, Thymoquinone, Black seeds, Dengue virus infection, POM (Petra/Osiris/Molinspiration) theory, Identification of antiviral pharmacophore site,

چکیده مقاله :

Background & Aim: The number of dengue virus (DENV) infection cases has increased dramatically over the past two decades, with an estimated 3.9 billion cases across the globe potentially at risk. Patients with a DENV infection are managed symptomatically and by supportive care since there is no approved antiviral drug yet for its management. On the other hand, N. sativa has been highlighted as a potential antiviral, particularly against DENV.Experimental: Hence, the anti-DENV potential of N. sativa is analyzed in this review using major databases, including Medline/PMC/PubMed, Scopus, EBSCO, EMBASE, Google Scholar, and Science Direct. Moreover, the Petra/Osiris/Molinspiration (POM) bioinformatics platform-2019 was used to analyze a series of compounds (1-15) identified in N. sativa (black seeds) to identify those with promising antiviral pharmacophore sites.Results: Preliminary research showed the potential of N. sativa in the control of Aedes aegypti mosquitoes and the enhancement of platelet counts. In addition, several clinical, animal, in vitro and in vivo studies have demonstrated the antiviral, immunomodulatory and anti-inflammatory properties of N. sativa. Furthermore, calculation of the physico-chemical properties of N. sativa compounds using POM analyses indicated that dithymoquinone possesses potential antiviral activity with two (O, O’) pharmacophore sites.Recommended applications/industries: As a result, N. sativa can be employed as an adjuvant/supportive therapy in the management of DENV infection in the early stages of the illness. Furthermore, N. sativa can be a source of new lead anti-DENV drugs.

چکیده انگلیسی:

Background & Aim: The number of dengue virus (DENV) infection cases has increased dramatically over the past two decades, with an estimated 3.9 billion cases across the globe potentially at risk. Patients with a DENV infection are managed symptomatically and by supportive care since there is no approved antiviral drug yet for its management. On the other hand, N. sativa has been highlighted as a potential antiviral, particularly against DENV.Experimental: Hence, the anti-DENV potential of N. sativa is analyzed in this review using major databases, including Medline/PMC/PubMed, Scopus, EBSCO, EMBASE, Google Scholar, and Science Direct. Moreover, the Petra/Osiris/Molinspiration (POM) bioinformatics platform-2019 was used to analyze a series of compounds (1-15) identified in N. sativa (black seeds) to identify those with promising antiviral pharmacophore sites.Results: Preliminary research showed the potential of N. sativa in the control of Aedes aegypti mosquitoes and the enhancement of platelet counts. In addition, several clinical, animal, in vitro and in vivo studies have demonstrated the antiviral, immunomodulatory and anti-inflammatory properties of N. sativa. Furthermore, calculation of the physico-chemical properties of N. sativa compounds using POM analyses indicated that dithymoquinone possesses potential antiviral activity with two (O, O’) pharmacophore sites.Recommended applications/industries: As a result, N. sativa can be employed as an adjuvant/supportive therapy in the management of DENV infection in the early stages of the illness. Furthermore, N. sativa can be a source of new lead anti-DENV drugs.

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