Green synthesis of isoquinoline derivatives using mlticomponent reaction of ninhydrin

محورهای موضوعی : Iranian Journal of Organic Chemistry

Samanehsadat Sharifi ¹ , Narjes Haeizadeh ²

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تاریخ دریافت : 1401/12/09 تاریخ پذیرش : 1401/12/09 تاریخ انتشار : 1401/11/12

کلید واژه: Ninhydrin, Spiro compounds, Acetylenedicarboxylates, N-Heterocycles,

چکیده مقاله :

In this work, The 1,3-dipolar intermediates generated by addition of isoquinoline to dialkyl acetylenedicaboxylates are trapped by ninhydrin to produce spiro compounds in excellent yields. In addition, for investigation of antioxidant ability radical trapping by DPPH and reducing power of ferric ion experiments was performed. As a result, synthesized compounds show excellent radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product and catalyst.