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Open Access Article
1 - Efficient Synthesis of Thiazolo[4,5-d]pyrimidine derivatives without solvent
Mohsen Nikpour4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a mu More4-Amino-5-bromo-2-substituted-aminopyrimidines were successfully reacted with various isothiocyanates in the alkaline alumina under Microwave irradiation to achieve a group of reported 2- aminothiazolo[4,5-d]pyrimidine derivatives . These compounds also carried out a multicomponent condensation with carbondisulfid and alkylhalides to furnish a group of reported 2- alkylsulfanylthiazolo[4,5-d]pyrimidine derivatives. Manuscript profile -
Open Access Article
2 - Synthesis 3 and 4-Dihydropyrimidinone and Thiones using Multi-Walled Carboxylated Carbon Nanotube Catalysts
maryam moghaddasIn the present study, the synthesis of 3 and 4-dihydropyrimidinone and thiones was investigated by Biginelli reaction in the presence of carbon dioxide nanoparticles (MWCNT COOH) as a catalyst. The use of carbon nanotubes has many advantages, including ease of product s MoreIn the present study, the synthesis of 3 and 4-dihydropyrimidinone and thiones was investigated by Biginelli reaction in the presence of carbon dioxide nanoparticles (MWCNT COOH) as a catalyst. The use of carbon nanotubes has many advantages, including ease of product separation, catalyst recovery capability, and environmental compatibility compared to liquid acidic catalysts. These catalysts are insoluble in most organic solvents and cause little corrosion. In addition, the catalyst is recovered without any reduction in its activity. Therefore, these catalysts can be used as a substitute for catalysts such as sulfuric acid. To investigate the effect of the catalyst on the organic reaction mentioned and to find the optimal conditions, first the synthesis of a derivative is selected as the reaction model and the effect of different reaction conditions such as the amount of catalyst, solvent type and temperature on it is examined. Other derivatives were then prepared under optimal conditions. In most cases, high product efficiency was achieved in a relatively short period of time. Comparing the conditions and results of the reactions performed in this study with other methods reported in the articles shows that the catalyst studied in this study was able to make the conditions of the reaction discussed in terms of time and efficiency, simple separation of products possible. Manuscript profile -
Open Access Article
3 - Quantitative monitoring of chromium (III) by a selective sensor based on dibenzo-18-crown-6 as a neutral ion carrier
Maryam Alaie Arezoo GhaemiIn present study a chromium (III) selective sensor based on dibenzo-18-crown-6 as a macrocyclic ionophore was fabricated. The best operation obtained in the membrane including: 5.0 mg dibenzo-18-crown-6 (DB-18C6), 4.0 mg sodium tetraphenylborate (NaTPB), 61.0 mg dioctyl MoreIn present study a chromium (III) selective sensor based on dibenzo-18-crown-6 as a macrocyclic ionophore was fabricated. The best operation obtained in the membrane including: 5.0 mg dibenzo-18-crown-6 (DB-18C6), 4.0 mg sodium tetraphenylborate (NaTPB), 61.0 mg dioctyl sabacate (DOS) and 30.0 mg polyvinyl chloride (PVC). This electrode has a good selectivity respect to Cr3+ cation, with a nernstian slope of 19.6±0.1 mV/decade in a linear concentration range of 1.0×10-5 M-1.0×10-1 M. The detection limit of the electrode is 8.8×10-6 M. The porposed sensor has a fast response time of 5 s and good reproducibility. It can be used for a period of 63 days without any significant changes in its potential. The effects of the pH and possible interfering ions were investigated. This electrode was employed as an indicator electrode in potentiometric titrations of chromium cation with EDTA solutions and a sharp break in titration curves around the equivalent point was observed. This sensor was successfully used for the determination of chromium (III) in real samples. Manuscript profile -
Open Access Article
4 - Synthesis and Characterization of 1-(2-Methyl-4-(4-methylbenzoyl)-7-thioxo-5-p-tolylpyrazolo[1,5-f]pyrimidin-1(7H)-yl)propan-2-one
Zülbiye Kökbudak Halime Aslan Zeynep Çimen Senem AkkoçCompounds containing pyrimidine ring attract researchers' attention due to their different properties. For example, Ishida et al. synthesized Cu(II) complexes having pyrimidine ring, and investigated their magnetic properties. By Wiśniewski et al., Ru(III), Rh(III), Pd( MoreCompounds containing pyrimidine ring attract researchers' attention due to their different properties. For example, Ishida et al. synthesized Cu(II) complexes having pyrimidine ring, and investigated their magnetic properties. By Wiśniewski et al., Ru(III), Rh(III), Pd(II) and Pt(II) metal complexes containing pyrimidine ring were designed and tested as in vitro against A549, LS-180 and MCF-7 cell lines for learning their cell proliferation activities. In the conducted study by Kökbudak et al., a series of various metal complexes were prepared from a Schiff base having pyrimidine core, and the cytotoxic activity properties of the complexes were screened against human lung cell line.In this study, 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)pyrimidin-2(1H)-thione (1) was prepared in two steps by the reaction of furan-2,3-dione and acetophenon thiosemicarbazone. 1-(2-Methyl-4-(4-methylbenzoyl)-7-thioxo-5-p-tolylpyrazolo[1,5-f]pyrimidin-1(7H)-yl)propan-2-one (2) was synthesized from compound 1 with α-chloracetone. The structure of new compound 2 was verified by FT-IR, 1H NMR, 13C NMR and elemental analyses. The theoretical properties of compound 2 was also calculated using Gaussian 09 program. Manuscript profile -
Open Access Article
5 - An Efficient One-Pot Synthesis of 1H-Pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives using MCM-41
Adel Ghasemi Haleh SanaeishoarAza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This work a new and efficient synthesis of phtha MoreAza heterocyclic compounds are major interest for organic chemists because of their mainly pharmacological activities and clinical applications such as antianxiety, antitumor, anticonvulsant, cardiotonic and vasorelaxant. This work a new and efficient synthesis of phthalazine drivatives from the three-component condensation reaction of malononitrile, phthalhydrazide and aromatic aldehydes using MCM-41 as catalyst. The features of this procedure are mild reaction conditions, good to excellent yields, short reaction times and operational simplicity.Mesoporous solids synthesized using micelles as structure directing agents have been found to posses’ large specific surface area, large pore volume, regular order of pore structure and tuneable pore characteristics Recently, the discovery of a new family of mesoporous molecular sieves designated as MCM-41 has been reported by researchers at the Mobil Corporation [3]. The MCM-41 material possesses a uniform hexagonal array of cylindrical pores embedded within a silica-based matrix. The material is synthesized through a hydrothermal reaction of silicate gel in the presence of a surfactant. Manuscript profile -
Open Access Article
6 - Green synthesis of pyranopyrazoles using Tungestic acid/Zr bio-based MOF as an efficient heterogeneous catalyst
Shima Khademi Saeed Zahmatkesh Alireza Aghili Rashid BadriThis reported work aims to fabricate an eco-friendly Zr bio-based MOF as a new magnetic nanocatalyst based on the immobilization of tungstic acid onto new design robust, cost-effective, green and scalable Zirconium-L-aspartate amino acid metal-organic framework (MOF)-gr MoreThis reported work aims to fabricate an eco-friendly Zr bio-based MOF as a new magnetic nanocatalyst based on the immobilization of tungstic acid onto new design robust, cost-effective, green and scalable Zirconium-L-aspartate amino acid metal-organic framework (MOF)-grafted L-(+)-tartaric acid stabilized magnetite nanoparticles (Fe3O4/Tart-NPs) was successfully prepared by two successive hydrothermal method. This catalyst was characterized by FT-IR, XRD, FE-SEM and TGA-DTA analysis. This catalyst is outstanding to prepare l ‐ (4 ‐ phenyl) ‐ 2,4 ‐ dihydropyrano [2,3 ‐ c] pyrazole derivatives in aqueous media due to the open metal sites, high and steady proton conductivity in the zirconium-MOF, MIP-202(Zr), MOF and also due to Brønsted acid properties of tungstic acid. This acidic catalyst can easily be extracted by an outward magnetic field after completion of the reaction without any deactivation or selectivity loss. The products were characterized by spectroscopic analysis (1HNMR,13CNMR and also FTIR). The optimized reaction conditions and a possible reaction mechanism is outlined. Manuscript profile
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