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  1 - The effect of a five-week cafeteria diet after weaning on the density of dendritic spines in the hippocampus and striatum of young rats
  sahar Molaei Mahsa Jafarinejad Farzaneh Ganji Hamid Sepehri Zahra Nazari
  Introduction & Objective:  Feeding with a cafeteria diet resulted in increased total body weight and obesity. This research aims to evaluate the effect of a cafeteria diet on the density of dendritic spines of hippocampal and striatum neurons from the end of in More

  Introduction & Objective:  Feeding with a cafeteria diet resulted in increased total body weight and obesity. This research aims to evaluate the effect of a cafeteria diet on the density of dendritic spines of hippocampal and striatum neurons from the end of infancy to the beginning of puberty. Materials & Methods: 22-day-old male and female Wistar rats that passed through infancy were randomly divided into two control and cafeteria groups (n=6). The control group had access to standard rat food, but the cafeteria group received a cafeteria diet in addition to standard food for up to 30 days. During the treatment, the rats of both groups were weighed every week. After five weeks after the start of the treatments, the brains of the mice were extracted and prepared for Golgi staining by the Rapid Golgi method. Results: Our results showed that the body weight increased significantly in the cafeteria group compared to the control group (P<0/01). In addition, the results showed that the cafeteria diet significantly reduces the density of dendritic spines in the hippocampus (P<0/01) and striatum (P<0/05) compared to controls. Conclusion: According to the results of the present study, the reduction of dendritic spines in the hippocampus and striatum, two important structures in cognitive behaviors, may cause memory and learning disorders observed in people consuming a high-fat diet. Manuscript profile
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  2 - The Effect of Grape Seed Extract on Lipid Peroxidation Duo to Ischemia/Hypoperfusion in Male Rat Striatum
  مریم رفیعی راد علیرضا سرکاکی سید ابراهیم حسینی یعقوب فربود سیدمحمدتقی منصوری فرشته معتمدی
  Introduction: Cerebralischemialeads toneuronaldeath invulnerablesectionsof brain thatisdue tofreeradical productionandoxidative damage. This study aimed to evaluate the effect of 28 days oral administration of grape seed extract (GSE) (100 mg/pkg(on brain oxidative stre More

  Introduction: Cerebralischemialeads toneuronaldeath invulnerablesectionsof brain thatisdue tofreeradical productionandoxidative damage. This study aimed to evaluate the effect of 28 days oral administration of grape seed extract (GSE) (100 mg/pkg(on brain oxidative stress indices after permanent bilateral common carotid arteries occlusion (2VO) or ischemia/hypo perfusion in male adult rats. Materials and methods: a number of 30 rats were divided into test and control groups. To make animal model of permanent cerebral hypo perfusion/ischemia, carotid arteries were ligatured upper and lower and cut bilaterally.RatbraintissuetoseparateStriatumandmeasurement ofmalondialdehydewereextracted. Results: results showed that chronic two-vessel occlusion (2VO) hypo perfusion-ischemia increases brain oxidants such as lipid per oxidation (LPO) (pandlt;0.001. (Post ischemic GSE treatment significantlyreducedLPO in striatum) pandlt;0.001(. Conclusion: GSE administration could remove or scavenge oxidants from brain tissue and improve its functionandpossiblybe used asa wayto treatthisdisease. Manuscript profile