List of Articles Tamoxifen

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  1 - Preparation of Novel Thermo-sensitive Polymer/βCD/WS2 Nano-carriers for invitro Drug Release of Tamoxifen in the Presence and Absence of Near-Infrared (NIR) Laser
  Abbas Bohloli Maryam Daghighi Asli Elham Moniri Azar Bagheri
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  2 - The Effect of Tamoxifen and Black Cohosh (Actaea racemosa) On The Changes In The Levels Of Sex Steroid Hormones And Oocytes Maturation Of Adult Female Gourami fish (Trichogaster trichopterus) from family (Osphronemidae)
  Mohsen Bagheri Tahereh Naji Homayoun Hosseinzade sahafi
  Introduction & Objective: One of the most common cancers in the menopausal age is breast cancer. To control menopause symptoms in women with breast cancer, given that hormone therapy is not recommended, alternative treatments such as phytoestrogen therapy can be con More

  Introduction & Objective: One of the most common cancers in the menopausal age is breast cancer. To control menopause symptoms in women with breast cancer, given that hormone therapy is not recommended, alternative treatments such as phytoestrogen therapy can be considered. Black cohosh is a phytoestrogen plant that is used to control menopause symptoms. The aim of this study was to compare the effect of tamoxifen with black cohosh plant on ovarian tissue ultrastructure and measurement of sex hormones in adult female three-spot gourami fish.Materials &Methods: For this purpose, the number of 120 pieces of three-spot gourami adult female fish with an average weight of 5±1 grams in 8 treatments with control groups including control 1 (intact) and control 2 (solvent, Ethanol 60 %) and treatments receiving doses of 10, 50, 100 mg/kg of tamoxifen drug and 10, 50, 100 mg/kg of black cohosh hydroalcoholic extract were divided. All the injections were done in 10 times and every other day for twenty days and in the amount of 0.02 ml between the dorsal fin muscle and the lateral line. Then, after anesthetizing the fish, the ovary was examined by light and electron microscope. For measuring the levels of steroid hormones, the fish tissue was homogenized by homogenizer.Results: Black cohosh extract decreased the level of 17-beta estradiol and testosterone hormones. Tamoxifen decreased the level of 17-beta estradiol, testosterone and progesterone hormones. Examining the light and electron microscope images showed that both tamoxifen and black cohosh had an inhibitory effect on oocyet maturation.Conclusion The results of this study showed that black cohosh plant extract and tamoxifen reduce oocyte maturation. Manuscript profile
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  3 - Effect of Tamoxifen on Oogenesis of the Female Wistar Rats
  زهرا کشتمند شهربانو عریان کاظم پریور
  Tamoxifen is a nonsteroidalantiestrogen which is prescribed for treatment of breast cancer. Some negative effects of this drug on the reproductive system have been observed.The major aim of this study is to investigate the effect of Tamoxifen on the oogenesis in female More

  Tamoxifen is a nonsteroidalantiestrogen which is prescribed for treatment of breast cancer. Some negative effects of this drug on the reproductive system have been observed.The major aim of this study is to investigate the effect of Tamoxifen on the oogenesis in female Wistar rats. Three group of rats (250 gr range ) gavaged with Tamoxifen doses of 200, 400 and 600 andmicro;g/kg B.W(exp.1, exp.2, exp.3 ) dissolved in solvent [ethanol 60 % and physiological solution] for 30 days. The sham group was gavaged with solvent and control did not receive solvent or drug. On days 1and 30 after the end of treatment, sections of ovary stained with Handamp;E method and were observed histologically. Results of the observation were analyzed by the one-way ANOVA, Tukey test and using SPSS software determined andplusmn;SEthe means Result were termed significant if Pandle;0.05. In the first sampling number of primordial follicle, secondary follicle ,graafian follicle and corpus luteum were decreased significantly in experimental groups which received Tamoxifen compared with control group [pandlt;0.001]. In the second sampling, number of primordial follicle secondary follicle, graafian follicle and corpus luteum increased compared with first sampling. The numbers of offsprings in experimental groups were less than control litters.These findings suggest thatTamoxifen decreases the fertilization ability and has negative effects on the oogenesis in female Wistar rats. Some of negative effects of Tamoxifen on reproduction ability, is abolished with time elapsed. Manuscript profile