List of Articles TGF-β

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  1 - Evaluation of Enzymatic changes in cholestasis index and TGF-β expression in cholestatic rat's liver were treated with ethanolic extract of Epimedium
  فاطمه Karimi, پژمان Mortazavi, A. Asghari,
  Liver fibrosis is one of the chronic and common diseases that is associated with increased production of excess collagen in the liver by star-shaped cells with increased TGF-β expression. Induction of cholestasis is one way which caused to liver fibrosis. The aim o More

  Liver fibrosis is one of the chronic and common diseases that is associated with increased production of excess collagen in the liver by star-shaped cells with increased TGF-β expression. Induction of cholestasis is one way which caused to liver fibrosis. The aim of the present study was to evaluate the antifibrotic effect of Epimedium extract on liver cholestasis induced by bile duct ligation (BDL) in rats. In this study, 40 male Wistar rats weighing 200-250 g were used. The rats were divided into 8 groups of 5, including healthy control, 3 healthy experimental were treated with doses of 100, 200 and 400 mg/kg of Epimedium extract, BDL group and 3 BDL were treated with mentioned doses. The rats were treated via intragastric gavage for 45 consecutive days (once per day). After 45 days, Alkalin phosphatase serumic level was measured after rats anesthesia and their serum isolation. Also, the rat's liver was fixed, colored and then evaluated via using the common immunohistochemical method with TGF-β antibody.The results showed a significant increase in serum levels of ALP enzyme and an increase in TGF-β expression in BDL group. Dose-dependent Treatment with Epimedium extract was able to improve these changes significantly. The results of this study showed that Epimedium extract probably improves the serum level of ALP enzyme by increasing the stability of cell membranes and also reduces the production and deposition of collagen in the liver by inhibiting the activation of stellar cells and inhibiting TGF-β expression.  Manuscript profile
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  2 - Protective effect of aerobic training and royal jelly on profibrogenic parameters of liver tissue and insulin resistance in obese rats
  Ali Asghar Ma'ghouli Ahmad Abdi asieh abbassi daloii
  10.30495/jftn.2022.64243.11164
  Introduction: Obesity is characterized by several metabolic complications such as increased profibrogenic parameters of liver tissue. Most anti-obesity drugs have liver side effects. The aim of this study was to investigate the protective effect of aerobic training and More

  Introduction: Obesity is characterized by several metabolic complications such as increased profibrogenic parameters of liver tissue. Most anti-obesity drugs have liver side effects. The aim of this study was to investigate the protective effect of aerobic training and royal jelly on profibrogenic parameters of liver tissue and insulin resistance in obese rats.Materials and Methods: In this experimental study, 45 male Wistar rats were divided into 5 groups: normal diet (ND), high fat diet (HFD), high fat diet - training (HFDT), high fat diet - royal jelly (HFDRJ) and high fat diet - training - royal jelly (HFDTRJ). The supplement groups received 100 mg of royal jelly (per kg of body weight) diluted in distilled water orally during the intervention period. Aerobic training program including running on treadmill with intensity of 50-60% VO2max was performed 5 days week for eight weeks. The genes expression of Transforming Growth Factor β (TGF-β) and Smad3 were measured by Real Time PCR. Results: There was significant increase of TGF-β, Smad3 and insulin resistance in HFD, HFDT, HFDRJ and HFDTRJ groups compared to ND group (P=0.001). Also, there was a significant decrease of TGF-β, Smad3 and insulin resistance in HFDT, HFDRJ and HFDTRJ groups compared to HFD group; and HFDTRJ compared to HFDRJ groups (P=0.001).Conclusion: It seems that the aerobic training with royal jelly can help to decrease of insulin resistance and improve the profibrogenic parameters of liver tissue in obesity caused by high-fat diet. Manuscript profile
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  3 - Effect Shrak cartilage on number and activity T-cell regulating cells in stomach cancer paitents
  razieh zareii محمد زهیر حسن صراف ابوالقاسم عجمی داریوش مسلمی امراله مصطفی زاده
  Introduction: Gastric cancer or gastric cancer, the fourth most common cancer and the second most common cancer in Iran and around the world Srtankshndh safety Ast.paskhhay in gastric cancer include innate and adaptive immunity Treg The cells in several malignancies inc More

  Introduction: Gastric cancer or gastric cancer, the fourth most common cancer and the second most common cancer in Iran and around the world Srtankshndh safety Ast.paskhhay in gastric cancer include innate and adaptive immunity Treg The cells in several malignancies including gastric cancer in Myyabdslvlhay increase in Treg immune response settings, maintaining homeostasis and immune tolerance, autoimmunity and cancer survival primarily as a treatment for cancer control Myknd.ghzrvf shark is .. Shark cartilage, a protein that angiogenesis (angiogenesis) in vitro and stop animal models. A network of blood vessels tumors need to survive and grow, so by blocking the blood supply to the tumor disappears,It was observed that in the group treated with shark cartilage cell viability Treg an average of 48/1% before treatment to 2/0% post treatment decrease the amount of cytokine inhibition of TGF-β from pg / ml183 before treatment pg / ml110 after treatment decreased, but the amount of cytokines in serum IFN-γ (pattern of cytokine TH1) of pg / ml160 before treatment pg / ml187 after treatment increased the amount of IL-4 (pattern of cytokine TH2) of pg / ml37 before treatment pg / ml30 after treatment decreased Is. In the control group there was no significant difference in the measurement.Final argument: Shark cartilage in people suffering from gastric cancer cell depletion inhibitory Treg and cytokine inhibiting TGF-β as well as a reduction in IL-4 (Aymvnyty cells, TH2) and increased production of IFN-γ (Aymvnyty cells, TH1) to enhance immune responses anti-tumor cell. Manuscript profile
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  4 - Comparison of the Effectiveness of Two Training Programs of Resistance Stretching and Plyometric Resistance on Hypertrophy (TGF-β1) and Muscle Strength in Female Handball Players
  zahra ahmadinia sareh hasani bahram abedi Mojtaba Khansooz
  Introduction: The present study was conducted with the aim of comparing the effect of resistance stretching and plyometric resistance exercises on TGF-β1 and muscle strength of female handball players.Methods: In this semi-experimental research, which was conducted More

  Introduction: The present study was conducted with the aim of comparing the effect of resistance stretching and plyometric resistance exercises on TGF-β1 and muscle strength of female handball players.Methods: In this semi-experimental research, which was conducted with a pre-test-post-test design, 36 female handball players in the age range of 18 to 30 years were randomly assigned to three groups of plyometric, stretching and control exercises. Muscle strength measurement and blood sampling were done in two stages, 24 hours before the intervention and 48 hours after the end of the intervention. They commented. The collected data were analized by dependent t-test, covariance and Bonferroni's post hoc test.Results: The results of the study showed that six weeks of plyometric resistance training and stretching resistance training have a significant effect on reducing the serum levels of TGF-β1 and increasing the muscle strength of the upper and lower limbs (P<0.05). Other results showed that there is a significant difference between the plyometric resistance training group and the stretching resistance training group in the levels of TGF-β1, upper and lower limb muscle strength (p<0.05). In addition, the results indicated a greater effect size of plyometric resistance training compared to stretching resistance training on research variables.Conclusion: According to the findings of the present study, it seems that plyometric resistance training can be more effective in reducing TGF-β1 serum levels and increasing muscle strength in female athletes than stretching resistance training. Manuscript profile
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  5 - بررسی ملکولی اگزون 2 ژن BMP15 به روش PCR-SSCP در گوسفند نژاد بلوچی ایران
  A. Gholibeikifard M. Amin Afshar M. Hosseinpour Mashhadi H. Mohammadi
  بالا بودن نرخ تخمک‌گذاری و بره‌زایی یکی از مهمترین عوامل تأثیرگذار بر افزایش کارآیی تولید مثل و به تبع آن افزایش کارآیی اقتصادی در صنعت پرورش گوسفند به حساب می‌آیند. علاوه بر تأثیر ژن‌های کوچک اثر، صفت چند‌قلوزایی تحت تأثیر ژن‌های بزرگ اثر نیز می‌باشد. پروتئین مورفوژنتی More

  بالا بودن نرخ تخمک‌گذاری و بره‌زایی یکی از مهمترین عوامل تأثیرگذار بر افزایش کارآیی تولید مثل و به تبع آن افزایش کارآیی اقتصادی در صنعت پرورش گوسفند به حساب می‌آیند. علاوه بر تأثیر ژن‌های کوچک اثر، صفت چند‌قلوزایی تحت تأثیر ژن‌های بزرگ اثر نیز می‌باشد. پروتئین مورفوژنتیک استخوان شماره 15 (BMP15) عضو فوق خانواده فاکتور رشد تغییر شکل دهنده بتا (TGF-β) می‌باشد که به طور خاص در اووسیت بیان شده و نقش تعیین کننده‌ای در باروری گوسفند دارد. گزارش شده جهش‌های مختلف در این ژن با روش حساس به دوز سبب افزایش نرخ تخمک‌گذاری و ناباروری در گوسفند می‌گردد. شش جهش در ژن BMP15 شناسایی شده‌اند که دارای اثر عمده بر روی باروری گوسفند است. هدف این پژوهش بررسی جهش لوکوس FecXL در باروری گوسفند نژاد بلوچی ایرانی بوده است. نمونه‌های خون کامل از وداج گردن و با استفاده از لوله خلاء دار حاوی ماده ضد انعقاد EDTA جمع‌آوری شدند و سپس DNA ژنومی از همه نمونه‌ها استخراج گردید. برای تعیین الگوهای باندی از روش چند شکلی فضایی تک رشته‌ای (SSCP) و همچنین توالی یابی استفاده گردید. نمونه‌های تعیین ژنوتیپ شده در این مطالعه وقوع آلل جهش یافته برای لوکاس FecXL را تأیید نکرد و تمامی نمونه‌ها در هر دو جایگاه از اگزون 2 ژن BMP15 دارای ژنوتیپ مونومورف بودند. Manuscript profile