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Open Access Article
1 - Antibacterial effect and chemical composition of Satureja bachtiarica
Nikta Ebrahimi Saghar Ketabchi Vahid RowshanIn this study antimicrobial activity of methanolic extract and essential oil of Satureja bachtiarica were evaluated by “disk diffusion method” on Pseudomonas syringae pv. syringae, Rhizobium radiobacter, Ralstonia solanacearum, Xanthomona MoreIn this study antimicrobial activity of methanolic extract and essential oil of Satureja bachtiarica were evaluated by “disk diffusion method” on Pseudomonas syringae pv. syringae, Rhizobium radiobacter, Ralstonia solanacearum, Xanthomonas axonopodis pv. citri, Bacillis subtilis, Pectobacterium cartovorum and Pectobacterium atrosepticum. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) determined by using a serial dilution method. The lowest inhibitory consistency of MIC and MBC values of Satureja bachtiarica essential oil and methanolic extract was observe on Bacillus subtillis. Chemical composition of essential oil and methanolic extract were determined by GC-MS and HPLC respectively. The major components of essential oil were: Carvacrol 53.94, γ- terpinene13.08, Tymole 11.16, P-symene 6.54, E- caryophylene2.16, Bornole1.2, Linalool2.49, α- terpnene. HPLC analysis of methanolic extract showed ten type of compound: Carcacrol (461.48mlgr/lit), Quercetin (75.80mlgr/lit) Eugenol (60.61mlgr/lit) Hesperetin (24.29mlgr/lit), Hesperedin(13.75mlgr/lit), Rutin (13.23mlgr/lit), Catechin (9.721mlgr/lit), Vanillin(1.01mlgr/lit), Caffeic acid (0.0812ml gr/lit), P-coumaric acid (2mlgr/lit), that are present in varying amount.Our result indicated that Satureja bachtiarica essential oil showed high antibacterial activity against all selected bacteria whereas, methanolic extract showed antibacterial activity against Xanthomona saxonopodis pv. citri, Bacillis subtilis, Ralstonia solanacearum, Pseudomonas syringae pv. syringae. In general, essential oil and methanolic extract have strong antimicrobial activity against these pathogens. Manuscript profile -
Open Access Article
2 - Acaricidal effect of two plant essential oils Pimpinella anisum and Satureja bachtiarica on two-spotted spider mite Tetranychus urticae (Acari: Tetranychidae)
M. H. Pourshab J. Karimi H. Abbasipour A. AhadiyatThe two-spotted spider mite, Tetranychus urticae is an important pest because of the word wide distribution, extensive host range, severe damage, great rate of population growth and ability in creating resistance against pesticides. In the present study, the acaricidal MoreThe two-spotted spider mite, Tetranychus urticae is an important pest because of the word wide distribution, extensive host range, severe damage, great rate of population growth and ability in creating resistance against pesticides. In the present study, the acaricidal effect of the essential oils of two plant species, Pimpinella anisum L.and Satureja bachtiarica Bungewere tested against the adults of Tetranychus urticae. Air-dried plant materials including seeds of P.anisum and herbage of S.bachtiarica, were distilled using a circulatory Clevenger-type apparatus. The essential oil was dried over anhydrous sodium sulphate and stored at +4ºC until tested. The amounts of the essential oils for P.anisum applied were 3.33, 6.66, 13.33, 26.66 and 53.33 μl/L air and for S.bachtiarica were 0.166, 0.33, 0.66, 1.33 and 2.66 μl/L. The vapours of these two plant species were toxic to adults of T. urticae. The value of LC50 on adults were 10.63 μl/L air for P.anisum and 0.33 μl/L air for S.bachtiarica. Also with increasing oil concentration, mortality rate of adults increased. According to results the P.anisum and S.bachtiarica essentials oil are appropriate in integrated pest management of two-spotted spider mite and can be considered as bio-pesticide. Manuscript profile -
Open Access Article
3 - Essential oil analysis and antibacterial activity of Satureja bachtiarica Bunge. in Ardebile province
مریم Teimori,The genus Satureja represents with 15 species in Iran, with 9 endomic species. In this study, the aerial parts of Satureja bachtiarica Bunge. with local name "Merzeh" in blooming were collected in Ardabil Province. Plant materials were dried in shade; essential oil was MoreThe genus Satureja represents with 15 species in Iran, with 9 endomic species. In this study, the aerial parts of Satureja bachtiarica Bunge. with local name "Merzeh" in blooming were collected in Ardabil Province. Plant materials were dried in shade; essential oil was obtained by hydro-distillation and analyzed by capillary gas chromatography, using flame ionization and mass spectrometric detection. The results showed the essential oil of S. bachtiarica contained (20.6%) thymol, (14.19%) linalool, (2.3%) γ-terpinene, (26.4%) carvacrol, (5.94 %) α-Terpinene, (3.56%) myrcene, as main components. Due to the antimicrobial effect of phenolic compounds, thymol and carvacrol, the antimicrobial effects of these oils were determined against five gram positive bacteria (Bacillus subtilis, Bacillus cereus, Micrococcus loteus, Staphylococcus areous) and three gram negative bacteria (Kellebsiella pneumonia, Kellebsiella oxytoca and Pseudomonas aeroginosa). The result showed the essential oils exhibited antibacterial activity against the tested strains, but in variable degree. The data indicated that Pseudomonas aeroginosa and Kellebsiella oxytoca were the most sensitive strain tested to the oils of S. bachtiarica and Bacillus cereus is known to have a high level of intrinsic resistance to virtually all known antibacterial and antibiotics. Manuscript profile -
Open Access Article
4 - Essential oil Screening and antioxidant activity of Satureja bachtiarica Bunge. population in Ilam Province for Isolation of Promising Chemotypes
maryam Mohamad-Zarin Abaadi Mehdi Saidi Yahia MohamadiThis work carried out in order to evaluating of oil yield, phytochemical variation and antioxidant activity of essential oils in different populations of Satureja bachtiarica Bunge. In west of Iran. So the aerial parts of eight wild populations of this plant were collec MoreThis work carried out in order to evaluating of oil yield, phytochemical variation and antioxidant activity of essential oils in different populations of Satureja bachtiarica Bunge. In west of Iran. So the aerial parts of eight wild populations of this plant were collected from different regions of Ilam, Gilane-Gharb provinces and one sample was collected in greenhouse of Ilam University, during 2010 and 2011. The essential oils were obtained by hydro distillation method, were analyzed by GC/MS and the antioxidant activity of them were measured by DPPH assay. The analysis were showed that the populations had significant differences regarding yield, phytochemical composition and their antioxidant activity. Maximum and minimum oil yield were recorded from Shalam and Greenhouse populations, respectively. The main components of plant oil were thymol (39.28-87.30%), p-cymene (0.15-30.63%), γ-terpinene (2.04-14.71%) and carvacrol (0-8.41%). The Shalam population had the highest phytochemical diversity and then the Shalam, Soregeh, KabirKooh and Ghalaarang populations were the most similar populations according to their phytochemical composition. Cluster analysis of populations, which using Ward Algorithm were divided them into three chemotypes. The highest and lowest total phenols contents were recorded in Ghalaarang (292.5±0.91 mg Pyrocatechol/ml) and Gerdakaan (194.04 ±1.08 mg Pyrocatechol/ml) population, respectively. The antioxidant activity of these populations varied from 59.1±0.9 to 73.8±0.45 % in Green house and Badreh, respectively .The Shalam population had the highest (IC50=0.67 mg/ml) in comparison with synthetic antioxidant BHT (0.11 mg/ml). In cluster B including populations of Soregah, Ghalaarang, Shalam, KabirKooh, Renou, and Badreh were remarked for further domestication processes. Manuscript profile -
Open Access Article
5 - Variation in the Essential Oil Constituents and Polyphenolic Contents of Satureja bachtiarica Bunge. from Six Populations of Fars Province
sahar yoosefi vahid Rowshan Kambiz Larijani Hasanali Naghdi Badi Ebrahim SabokiAbstract Satureja is belonging to the family Lamiaceae. Satureja bachtiarica Bunge. is one of the endemic species. In this study, aerial parts of S. bachtiarica were colleted in full flowering stages from six populations of Fars Province and after were dried in laborato MoreAbstract Satureja is belonging to the family Lamiaceae. Satureja bachtiarica Bunge. is one of the endemic species. In this study, aerial parts of S. bachtiarica were colleted in full flowering stages from six populations of Fars Province and after were dried in laboratory conditions, the essential oils (EOs) and extracts were obtained by hydrodistillation and macetation methods. Chemical compositions of the EOs were analyzed by GC-FID and GC-MS and the phenolic contents were determined by HPLC analysis. EO yields were from 1.1 to 2.4 % (w/w) based on dried material. The major constituents of the EOs were thymol ( 10.9-49.8 %), carvacrol (1.1-49.7 %), p-cymene (18.0-32.8 %), γ-terpinene (4.3-7.5 %), linalool (3.3-5.1 %) and caryophyllene oxide (1.6-2.3 %). Among six populations, the EOs from the Kohanjan and Abadeh-Didegan populations had the highest thymol and carvacrol amount (49.8 and 49.7 %), respectively. Narengenin, carvacrol, hesperedin, eugenol, hesperetin, rosmarinic acid and thymol were the main phenolic copmounds in six studied regions. These results showed that variation of ecological characters had effect on quality of S. bachtiarica EOs and extracts. Manuscript profile -
Open Access Article
6 - Evaluation of the foliar application effect of salicylic acid on the morpho-physiological and phytochemical traits of the essential oil from Satureja bachtiarica Bunge. under deficit irrigation conditions
َAzam Shaykh Samani Prof. Abdollah Ghasemi Pirbalouti Mmehrab Yadegari F. RajabzadehCultivation of Satureja bachtiarica Bunge. in dry conditions requires the use of novel methods to obtain the highest yield of the effective medicinal substances. This investigation was done to investigate the effect of foliar application of salicylic acid (SA) at 1 mM o MoreCultivation of Satureja bachtiarica Bunge. in dry conditions requires the use of novel methods to obtain the highest yield of the effective medicinal substances. This investigation was done to investigate the effect of foliar application of salicylic acid (SA) at 1 mM on the morpho-physiological and phytochemical traits of S. bachtiarica under water deficit conditions during two experimental years (2017-2018 and 2018-2019) in Shahrekord, Iran. The experiment was performed as a factorial in a CRBD with three replications, which irrigation treatment in two levels [normal irrigation (irrigation after draining 30% F.C.) and deficit irrigation (irrigation after draining 50% F.C.)], and the foliar application at two levels (control and SA) were considered. The essential oil from the aerial parts of the herb was extracted by water distillation and analyzed by GC/MS. The content of chlorophyll a, b and total at 663 and 645 nm, carotenoids at 470 nm and the content of proline at 520 nm were determined using a spectrophotometer. According to the results, water deficit stress caused the physiological and phytochemical changes in S. bachtiarica. As the amount of proline (139%), chlorophyll a (57%), b (46%) and total (55%), the essential oil content (7%) and carvacrol as the major compound (7%) increased under water deficit stress. The highest values of the essential oil content (1.67% v/w), the concentrations of carvacrol (45.7%) and p-cymene (18.6%) were obtained under deficit irrigation under SA. The maximum levels of thymol and β-caryophyllene were achieved from the herbs under deficit irrigation as well as SA foliar application. Totally, SA as a defense factor reduced the negative effects of deficit irrigation conditions on most of the evaluated traits. In conclusion, the foliar-spraying of salicylic acid is recommended for stabilize of the quantity and quality of the active substance yield of S. bachtiarica under water deficit stress. Manuscript profile -
Open Access Article
7 - بررسی اثر عصاره الکلی مرزه بختیاری بر زخم معده القا شده با الکل در موش صحرایی
فیروزه سقایی عبدالرسول نامجوBackground & Aim: Free radicals play an important role in the development of some diseases, including gastrointestinal ulcers. Current gastric ulcer drugs have side effects, so the tendency to use herbs and replace them with synthetic drugs has increased. In this re MoreBackground & Aim: Free radicals play an important role in the development of some diseases, including gastrointestinal ulcers. Current gastric ulcer drugs have side effects, so the tendency to use herbs and replace them with synthetic drugs has increased. In this regard, plants of the Satureja family have been studied in terms of healing and antioxidant properties. The aim of this study was to evaluate the protective effects of Satureja bachtiarica ethanolic extract on ethanol-induced gastric mucosal ulcers in rats.Experimental: Thirty rats were divided into 5 equal groups. Group 1 received 200 mg / kg of ethanolic extract of Satureja bachtiarica (EESB), group 2 received 400 mg / kg EESB, group 3 received 20 mg / kg omeprazole, group 4 received 1 mL of CMC and group 5 received 1 mL of normal saline. One hour after treatment, each animal received absolute ethanol (1ml / rat) orally by gavage. The other 30 mice were treated with oral ethanol after induction of gastric ulcer as described above, but all treatments were once a day for 14 days. At the end of both tests, ulcer index, histopathologic exams, Malonedialdehyde (MDA) and Superoxide dismutase (SOD) were measured.Results: Ethanolic extract of Satureja bachtiarica (400 mg/kg) and omeprazole had a significant effect on reducing ulcer index and increasing ulcer inhibition. It significantly preserved the gastric wall mucosa and reduced the formation of ethanol-induced gastric lesions. Also in this study a significant increase in superoxide dismutase (SOD) activity and a significant decrease in Malonedialdehyde (MDA) in gastric tissue were observed.Recommended applications/industries: The anti-ulcer effect of this plant seems to be due to the reduction of oxidative stress, which is probably due to the presence of thymol and carvacrol in the plant extract. This plant may be considered officially in the treatment and prevention of stomach ulcers in the future. Manuscript profile -
Open Access Article
8 - کاهش نیتریت در سوسیس با استفاده از روش سطح پاسخ و بکارگیری اسانس مرزه ی بختیاری و پودر گوجه
بنفشه محمدی نفیسه جهانبخشیان مریم جعفریBackground & Aim: The use of synthetic additives is one of the main approaches for preventing microbial growth and oxidative reactions in meat products. These preservatives were recently marked as unhealthy to humans; therefore, the consumers demand for fresh, natur MoreBackground & Aim: The use of synthetic additives is one of the main approaches for preventing microbial growth and oxidative reactions in meat products. These preservatives were recently marked as unhealthy to humans; therefore, the consumers demand for fresh, natural, and negligibly processed products with lower content of artificial additives is increasing.Experimental: The effect of Satureja bachtiarica Bunge essential oil (EO) and tomato powder (TP) to optimize sausage formulation with reduced nitrite content was investigated. Response surface methodology (RSM) was used to investigate the effects of different levels of EO (200-400 ppm), TP (5-15%) as Hurdles, and sodium nitrite (SN) (0-300 ppm) in sausage formulation during storage (0- 24 days). Dependent variables including residual nitrite, pH, color indices, microbial load, and hardness were investigated and finally model optimization and validation were conducted.Results: The results showed that residual nitrite was strongly depending on initial added nitrite and storage time (p<0.001), so the use of nitrite substituent was undeniable to have an improved sausage formulation without microbial defect. RSM represented a quadratic model for all responses except in texture which was linear and the pH and microbial load showed interaction. The optimized predicted values for SN, EO and TP were 56 ppm, 378 ppm and 5%, respectively. The model validation revealed that the results of the experiments were in good agreement with the predicted values.Recommended applications/industries: The results of the present study can be useful for consideration in meat products industry to reduce the nitrite level in sausage formulation. Manuscript profile -
Open Access Article
9 - اثر اسانس چند گیاه دارویی بر سیستم ایمنی ماهی قزل آلای رنگین کمان Oncorhynchus mykiss
عبدالله قاسمی پیربلوطی اسماعیل پیرعلی غلام رضا پیشکار سید محمدعلی جلالی مهدی رئیسی محسن جعفریان دهکردی بهزاد حامدیمقدمه و هدف: اهمیت ماهی قزل آلا رنگین کمان (Oncorhynchus mykiss) در صنعت آبزی پروری ایران از یک سو و افزایش تلفات ناشی از تنش های مختلف مانند شیوع بیماری های عفونی و عدم تأثیر داروهای سنتزی از سوی دیگر، ما را بر آن داشت تا تحقیق حاضر را به منظور بهبود سیستم ایمنی و کاهش Moreمقدمه و هدف: اهمیت ماهی قزل آلا رنگین کمان (Oncorhynchus mykiss) در صنعت آبزی پروری ایران از یک سو و افزایش تلفات ناشی از تنش های مختلف مانند شیوع بیماری های عفونی و عدم تأثیر داروهای سنتزی از سوی دیگر، ما را بر آن داشت تا تحقیق حاضر را به منظور بهبود سیستم ایمنی و کاهش تلفات این ماهی با استفاده از ترکیبات طبیعی مانند اسانس گیاهان دارویی به مرحله اجرا درآوریم. روش تحقیق: به منظور بررسی اثر چند گیاه دارویی بر سیستم ایمنی ماهی قزل آلای رنگین کمان، آزمایشی در قالب یک طرح کاملاً تصادفی با 7 تیمار و 3 تکرار و در هر تکرار 12 قطعه ماهی در مجموع با 252 قطعه ماهی با میانگین وزن 5 ±50 گرم به مدت 8 هفته انجام گرفت. هفت تیمار آزمایش شامل 1% اسانس مرزه بختیاری، آویشن دنایی، مرزه خوزستانی، زرین گیاه، پونه کوهی، جیره معمولی+روغن زیتون و جیره معمولی (شاهد) بود. نتایج و بحث: نتایج این پژوهش نشان داد که بالاترین میزان صفات مربوط به شاخص های ایمنی یعنی درصد فاگوسیتوز و تعداد جرم فاگوسیته شده و میزان Igm در اثر تغذیه اسانس 3 گیاه پونه کوهی، مرزه خوزستانی، زرین گیاه بود (05/0>p). میزان لنفوسیت ها و هتروفیل های خون ماهی های تغذیه شده با جیره حاوی اسانس مرزه بختیاری در مقایسه با شاهد به ترتیب کاهش و افزایش مشاهده گردید (05/0>p). توصیه کاربردی/ صنعتی: در مجموع نتایج این تحقیق نشان داد که افزودن 1% اسانس گیاهان دارویی به خصوص پونه و مزره بختیاری به روغن زیتون به همراه جیره غذایی ماهی قزل آلای رنگین کمان سبب تقویت سیستم ایمنی ماهی می شود. Manuscript profile -
Open Access Article
10 - اثر ضد درد و ضد التهاب عصاره هیدروالکلی گیاه مرزه بختیاری بر موش سوری
فیروزه سقایی صادق معتمدیمقدمه و هدف: استفاده از داروهای ضد درد و ضد التهاب در طب بالینی ضروری و اجتناب ناپذیر است. از طرفی مصرف روز افزون داروهای شیمیایی، عوارض جانبی متعددی را به همراه دارد که اغلب خطرناک بوده و لذا استفاده از گیاهان دارویی با عوارض جانبی احتمالی کمتر، به عنوا Moreمقدمه و هدف: استفاده از داروهای ضد درد و ضد التهاب در طب بالینی ضروری و اجتناب ناپذیر است. از طرفی مصرف روز افزون داروهای شیمیایی، عوارض جانبی متعددی را به همراه دارد که اغلب خطرناک بوده و لذا استفاده از گیاهان دارویی با عوارض جانبی احتمالی کمتر، به عنوان تسکین درد و التهاب از اهمیت بالایی برخوردار است. گیاه مرزه بختیاری با داشتن ترکیبات تیمول، پاراسایمن، منتون و کارواکرول احتمالاً میتواند درد را تسکین و التهاب را کاهش دهد. روش تحقیق: از 75 سر موش سوری نر (با وزن 30 - 20 گرم) در 15 گروه آزمایشی استفاده شد. روش کار شامل آزمون رایزینگ و فرمالین برای بررسی اثرات ضد درد و آزمون گزیلن برای بررسی اثر ضد التهاب بود. عصاره گیاه در دوزهای 400 و 600 و 800 میلیگرم بر کیلوگرم وزن موش، مرفین ( 10میلی گرم بر کیلوگرم) در آزمون درد و دگزامتازون (10 میلی گرم بر کیلوگرم) در آزمون التهاب به عنوان کنترل مثبت استفاده شدند. نتایج و بحث: عصاره الکلی گیاه مرزه بختیاری در مقایسه با گروه کنترل به طور معناداری سبب کاهش درد گردید ولی اثر ضد التهاب این دارو با آزمون گزیلن اثبات نشد که نیاز به بررسی بیشتر از طریق آزمونهای دیگر دارد. توصیه کاربردی/صنعتی: با توجه به نتایج، اثر ضد درد عصاره با مرفین قابل مقایسه بوده است، لذا به نظر میرسد با تحقیقات بیشتر در آینده بتوان از این گیاه در تسکین درد بهره برد. Manuscript profile -
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11 - اثر سمیت سلولی عصاره هیدروالکلی مرزه بختیاری بر روی رده سلول های سرطانی Hela
آناهیتا اروند شوشتر حسین سازگار عبداله قاسمی پیربلوطیمقدمه و هدف: سرطان دهانه رحم شایع­ترین سرطان دستگاه تناسلی زنان و دومین سرطان شایع زنان در دنیاست. با توجه به این­که ترکیبات گیاهی قرن­هاست که برای درمان سرطان استفاده می­شود، هدف از این مطالعه بررسی اثر سمیت سلولی عصاره هیدروالکلی مرزه بختیاری بر روی رد Moreمقدمه و هدف: سرطان دهانه رحم شایع­ترین سرطان دستگاه تناسلی زنان و دومین سرطان شایع زنان در دنیاست. با توجه به این­که ترکیبات گیاهی قرن­هاست که برای درمان سرطان استفاده می­شود، هدف از این مطالعه بررسی اثر سمیت سلولی عصاره هیدروالکلی مرزه بختیاری بر روی رده سلول­های سرطانی Hela بود. روش تحقیق:رده سلول­های سرطانی Hela و رده سلول­های طبیعی فیبروبلاست به ترتیب در محیط کشت RPMI 1640 و DMEM حاوی سرم جنین گاو و آنتی­بیوتیک کشت گردیدند. این سلول­ها در مجاورت دوز­های مختلف عصاره هیدروالکلی مرزه بختیاری (156/0، 312/0، 625/0، 25/1 و 5/2 میلی­گرم بر میلی­لیتر) قرار گرفتند و به مدت 24، 48 و 72 ساعت انکوبه شدند. پس از پایان مدت انکوباسیون، از روش تغییر یافته آزمون رنگ­سنجی MTT جهت تعیین سمیت سلولی عصاره استفاده شد. نتایج و بحث: نتایج حاصل از تستMTT نشان داد که عصاره هیدروالکلی مرزه بختیاری اثر ضد سرطانی وابسته به دوز و زمان بر سلول­های سرطانی Hela دارد، به طوری که با افزایش غلظت عصاره و انکوباسیون 72 ساعت بیشترین درصد مرگ سلولی مشاهده شد (05/0p<). عصاره گیاه سمیت سلولی قابل توجهی بر روی رده سلول­های طبیعی فیبروبلاست نشان نداد. لذا به نظر می­رسد با تحقیقات بیشتر در آینده می­توان از ترکیبات آن­ در درمان سرطان بهره جست. توصیه کاربردی/صنعتی: با توجه به اثرات جانبی کم داروهای گیاهی بویژه آنتی­اکسیدان­ها از جمله مرزه بختیاری می­تواند در درمان سرطان در کنار دارو درمانی استفاده شود. Manuscript profile -
Open Access Article
12 - Protecting Effect Extracts of Satureja bachtiarica and Thymus daenensis Celak against Hepatic Fibrosis Induced by Thioacetamide on Rat
H. Sazegar F. Fadaei Sh. Mashadizadeh N. Ziajahromi F. Sadeghi Samaninowadays, one of the problems of human societies is liver diseases and using chemical drugs with their side effects, causing the researchers change their approaches towards new sources of herbal drugs .The aim of this study was to investigate the effect of Satureja bach Morenowadays, one of the problems of human societies is liver diseases and using chemical drugs with their side effects, causing the researchers change their approaches towards new sources of herbal drugs .The aim of this study was to investigate the effect of Satureja bachtiarica and Thymus daenesis Celak the liver damage is caused by injection thioacetamide. 54 male wistar rats were randomly selected and divided into 9 groups of 6 each groups the (first sahed, second of positive control, third of negative control, fourth, fifth, sixth extracts of Satureja bachtiarica with 5, 10 and 20 miligram per kilogram ,seven , eight and nine extract of Thymus daenensis Celak with 5, 10 and 20 mg/kg extract were given by gavage.Thioacetamide first for three week and twice weekly a rats of 1cc to all groups except the control group were injection then gavage for 14 days savory and thyme extract groups were treated with the extract and the positive drug control group treated with 8 mg/kg capsule sibilinin slap for 14 days.then the blood samples were taken and liver of rats. Histopathologic study suggests that liver lesions compared to the control group is related to the negative control group .Aspartate aminotransferase and alanine aminotransferase well as in the study were assessed and showed that extracts of thyme daenensis has a positive effect on liver fibrosis. By studying the findings, it seems that Flavonoid compounds and phenolic in Thymus daenesis Celak and Satureja bachtiarica can decrease the toxic effects induced By thioacetamide In liver tissue of Mice. Manuscript profile
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