Internet of Things (IoT) technology offers a structured approach to address aspects of health care delivery in terms of health and remote monitoring for patients with specific conditions and life-threatening diseases. The Internet of Things will generate an unprecedente More
Internet of Things (IoT) technology offers a structured approach to address aspects of health care delivery in terms of health and remote monitoring for patients with specific conditions and life-threatening diseases. The Internet of Things will generate an unprecedented amount of data that can be processed using cloud computing, which will result in huge delays due to resource limitations. But for real-time remote health monitoring applications, the delay caused by transferring data to the cloud and back to the application is unacceptable. we proposed remote monitoring of patient health in smart homes using the concept of fog computing in smart gateway. The FOG detection system implemented under fog computing consisted of a linear map and a Mobius map in combination with fuzzy logic to create a multi-level output (MLFM-map) that exploits different spatial resolutions in motion data analysis. The model architecture and parameters are designed to provide optimal performance while reducing computational complexity and testing time. The proposed approach showed good to excellent classification performance, with an accuracy of more than 90% of FOG episodes detected on average with very low latency in the original dataset
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Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta More
Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta through a 30-gauge cannula. The group control1 received saline on the left side of the Substantia Nigra pars compacta.Then, to investigate the effect of the Naringenin, group control2 received distilled water and other groups received Naringenin via gavage for two weeks, and apomorphine induced rotation, catalepsy, and behavioral tests were assessed in all groups. Hematoxylin and eosin staining was performed and the percentage of the neurons on the left side of the Substantia Nigra pars compacta were calculated. In this study, in cell culture model, dopaminergic-like neurons cultured in DMEM medium were counted, and cells were used and incubated to evaluate the effect of naringinin against 6-hydroxy dopamine. Concentrations were 50 for 6-hydroxy dopamine solution and 0.25, 0.1 and 0.01 for NAR solution. Finally, cell viability was assessed using MTT and trypan blue methods.Results: 6-Hydroxy dopamine increased catalepsy and contralateral turns compared to the control group. Naringin reduced catalapsy and contralateral turns, it reduced anxiety and depressive-like behaviours besides that it increased swimming time and locomotor activity compared to the control group. Conclusion: it seems that Naringin is a therapeutic option for neurodegenerative disorders, such as Parkinson's disease.
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مینه وهدف: بیماری پارکینسون نوعی تحلیل در سیستم عصبی است که با اختلالات حرکتی متعددی شناخته می‌شود. عواملی از قبیل استرس اکسیداتیو از مهم‌ترین علل دژنراسیون نورون‌های دوپامینرژیکی جسم سیاه و ایجاد پارکینسون به شمار می روند. بنابراین داروهایی که دارای عمل آنت ی اکسیدانی More
مینه وهدف: بیماری پارکینسون نوعی تحلیل در سیستم عصبی است که با اختلالات حرکتی متعددی شناخته می‌شود. عواملی از قبیل استرس اکسیداتیو از مهم‌ترین علل دژنراسیون نورون‌های دوپامینرژیکی جسم سیاه و ایجاد پارکینسون به شمار می روند. بنابراین داروهایی که دارای عمل آنت ی اکسیدانی م ی باشند، می توانند ب ه عنوان هدف جالب توجهی برای درمان اختلالات حرکتی پارکینسون باشند . بابونه منبع طبیعی آنتی اکسیدان است. مواد و روش ها: در این مطالعه از 50 سر موش صحرایی نر بالغ استفاده‌گردید که به‌طور تصادفی به گروه‌های 10تایی کنترل، پارکینسونی، و سه گروه پارکینسونی که روزانه یک‌بار به مدت 14روز به ترتیب دوزهای mg/kg10،25و 50 عصاره گل بابونه را به روش گاواژ دریافت نمودند، تقسیم شدند. بیماری پارکینسون با تزریق 8میکروگرم سم عصبی 6_هیدروکسی دوپامین (6-OHDA) در 2میکرولیتر سالین دارای 1% اسید اسکوربیک درون دسته میانی_قدامی (MFB)نیمکره چپ مغز موش‌ها القاء شد. نتایج به صورت میانگین و انحراف از معیار( mean± SEM)، آنالیز و واریانس یک طرفه و تست پشتیبان TUKEY ارائه شدند. یافته ها: ضایعه در MFB سمت چپ مغز با 6-OHDA موجب‌گردید تا 14 روز بعد از ضایعه حیوانات متعاقب تجویز زیرجلدی mg/kg 5/2 آپومورفین در جهت راست به میزان 10< دور در دقیقه چرخش 360 درجه داشته باشند و نیز در تست‌های حرکتی (حفظ تعادل، بی‌حرکتی و طول قدم) نسبت به گروه کنترل اختلاف معنی‌داری را نشان دادند. درمان حیوانات پارکینسونی با دوزهای مختلف عصاره گل بابونه در مقایسه با گروه پارکینسونی بدون درمان، موجب بهبودی معنی‌دار فعالیت‌های حرکتی گردید و دوز mg/kg10 و 50 بیشترین اثرات درمانی را نشان دادند. توصیه های کاربردی/صنعتی: عصاره گل بابونه احتمالا ًبه‌دلیل خاصیت آنتی‌اکسیدانی قوی و تداخل با فعالیت گیرنده‌های مسیرهای حرکتی می‌تواند جهت بهبود و کاهش اختلالات حرکتی پارکینسون مورد استفاده قرار گیرد.
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Oxidative stress and neuroinflammation play a role in Parkinson's disease. Antioxidants and anti-inflammatories such as polyphenol compounds and flavonoids inhibit neuronal death. The aim of the present study is the effect of xanthone and 6-hydroxyflavone in Parkinson's More
Oxidative stress and neuroinflammation play a role in Parkinson's disease. Antioxidants and anti-inflammatories such as polyphenol compounds and flavonoids inhibit neuronal death. The aim of the present study is the effect of xanthone and 6-hydroxyflavone in Parkinson's disease in laboratory mice. Animals are cannulated by stereotaxic surgery and unilateral injection of 6-hydroxy-dopamine is performed in the dense area of the substantia nigra (SNc) of the brain. Xanthone and 6-hydroxyflavone were injected intraperitoneally. Three weeks after surgery, movement evaluations and pseudo-anxiety and pseudo-depression behaviors were performed. Counting of all the neurons in the dense area of the substantia nigra was done. Injection of 6-hydroxydopamine increased the number of apomorphine rotations. Catalysis time increased. Neurons in the substantia nigra decreased. 6-Hydroxyflavone (50 and 100 mg/kg) and xanthone (100 and 200 mg/kg) reduced vertigo and catalepsy. In the elevated plus shape maze test, 6-hydroxyflavone in doses of 25 and 50 mg/kg and xanthone in doses of 50 and 100 mg/kg increased motor activity. In the forced swimming test, xanthone in doses of 50, 100 and 200 mg/kg reduced immobility in parkinsonian rats. The number of substantia nigra neurons increased with the treatment of 6-hydroxyflavone in doses of 50 and 100 mg/kg and 200 mg/kg xanthone. Xanthone and 6-hydroxyflavone improved movement disorder and catalepsy and increased the number of nerve cells in the substantia nigra. Xanthon was able to reduce depression. Probably, part of these central protective effects are mediated by the antioxidant and anti-inflammatory effects of xanthone and 6-hydroxyflavone, which prevent cell death by reducing free radicals and inflammatory cytokines, and as a result, they improve cognitive and movement disorders.
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