List of Articles Oxaliplatin

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  1 - Quantum Mechanical Study of the Structure, NBO and HOMO–LUMO Analysis of Molecule Oxaliplatinium
  Reza Ghiasi Nooshin Parseh
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  2 - Theoretical insights into the encapsulation of anticancer Oxaliplatin drug into single walled carbon nanotubes
  Mahyar Rezvani Iran Ahmadnezhad Masoud Darvish Ganji Maria Fotukian
  10.22034/jna.2016.03.001
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  3 - Investigation of effect of oxaliplatin and paclitaxel drugs on colon cancer cells(HT29) and analysis of apoptotic genes expression caspase 3, caspase 9 and P53
  H. Mahmoodzadeh Javad Baharara Yeganeh Rezaiee Daloui
  10.30495/jdb.2023.1966139.1329
  Aim: In this study the effects of paclitaxel and oxaliplatin on colon cancer cell line (HT29) and expression of apoptotic genes caspase 3, 9, and p53 were examined.Material and methods: Using the MTT method, the cytotoxicity of paclitaxel and oxaliplatin and synergic ef More

  Aim: In this study the effects of paclitaxel and oxaliplatin on colon cancer cell line (HT29) and expression of apoptotic genes caspase 3, 9, and p53 were examined.Material and methods: Using the MTT method, the cytotoxicity of paclitaxel and oxaliplatin and synergic effect at different concentrations on the HT29 cell line was assessed. The IC50 of paclitaxel and oxaliplatin was determined.The expression level of caspase 3 and 9 was assessed using the Real-Time PCR method after the cells had been exposed to the IC50 concentration. Apoptosis of the cells was done using Annexin V/PI and DAPI staining.Results: The treatment of cells revealed that paclitaxel and oxaliplatin at concentrations of 3.25 and 0.00062 µg/ml , respectively, have the most cytotoxic effects and its IC50 value was determined to be 12.5 µg/ml and 0.00016 and treatment groups at concentrations of 3.25 and 0.00062 µg/ml , respectively, decreased the cell viability and its IC50 value was determined to be 12.5 µg/ml and0.00016µg/m. The expression level of caspase 3 and 9 P53 was also increased in the treated colon cancer cell line. DAPI staining showed apoptosis in the simultaneous treatment groups with. Using Annexin V/PI reveals that 98 percent of the cells in the control group are healthy and a considerable number of the cells in the treated groups have undergone apoptosis. Conclusion: Is. It is clear that paclitaxel and oxaliplatin are effective options for treating colon cancer given their cytotoxicity and stimulation of the apoptotic process in colon cancer cell lines. Manuscript profile
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  4 - Comparison of the Effects of Oxaliplatin on Nitric Oxide Synthase Activity in Colorectal Cancer (SW480) Compared to Normal Cells (HEK293)
  Seyed َAyoub Ahmadi Tahereh Naji Rahim Ahmadi
  10.22034/ascij.2023.1990060.1508
  Colon cancer is one of the most common tumors in the human population. There are many drugs on the market to treat different types of cancer, but their use is limited due to toxic effects and side effects, and in the last ten, experts in this field are looking for suita More

  Colon cancer is one of the most common tumors in the human population. There are many drugs on the market to treat different types of cancer, but their use is limited due to toxic effects and side effects, and in the last ten, experts in this field are looking for suitable alternatives to common anti-cancer drugs. This study was aimed to assess the comparison of the effects of oxaliplatin on the nitric oxide level in colorectal adenocarcinoma SW480 and non-tumor HEK293 cell lines. In this experimental study, Oxaliplatin was prepared at concentrations of 1.95, 3.90, 7.8, 15.6, 32.25, 62.5, 125, 250 and 500 μg/ml and the cytotoxic effect was investigated on HEK293 and SW480 cell lines using MTT method. Nitric oxide was measured by Grease method and Real Time PCR technique was applied to evaluate the iNOS gene expression. Finally, one-way ANOVA and t-test were used to analyze the data. The results of this study indicated that Oxaliplatin had a lethal effect on the SW480 cell line at concentrations of 7.8 to 250 μg/ml, but showed no cytotoxic effects on normal cell lines at other concentrations. Oxaliplatin at concentrations of 10, 20, and 40 μg/ml significantly increased nitric oxide production in SW480 cells compared to HEK293 cells, which served as the normal cell line. The results of Real Time PCR showed that the expression of the iNOS gene in both SW480 and HEK293 cells was not significantly different from the control group, but was higher. The results indicated that use of oxaliplatin can cause excellent therapeutic effects on cancer cell lines with minimum side effects. Manuscript profile