List of Articles Noradrenalin

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  1 - The effect of intracerebroventricular injection of L-DOPA and 6-hydroxy-dopamine on noradrenaline-induced food intake in layer chickens
  F. Zanganeh, N. Panahi, M. Zendehdel,
  Food intake is regulated by a complex system of central and peripheral signals which ‎interact ‎together to modulate appetite. Noradrenaline has an essential role in the central ‎control of food ‎intake in birds. On the other hand, dopamine (DA) is a hyp More

  Food intake is regulated by a complex system of central and peripheral signals which ‎interact ‎together to modulate appetite. Noradrenaline has an essential role in the central ‎control of food ‎intake in birds. On the other hand, dopamine (DA) is a hypophagic ‎agent in birds. ‎The present ‎study aimed to investigate the effect of L-DOPA and 6-‎hydroxy-dopamine on noradrenaline-induced food intake in neonatal chickens. A total ‎of ninety-six neonatal female laying hens (Hy‎line) were randomly divided into two ‎experimental groups. Immediately after ‎intracerebroventricular (ICV) injection of ‎control diluent (normal saline) or drug solution, ‎cumulative food intake (g) was ‎measured based on the ‎percentage of the body weight (%BW). ‎Control solution (normal ‎saline, group1), L-DOPA (125 nmol, group 2), noradrenaline (300 nmol, ‎group 3), and ‎L-DOPA + noradrenaline (group 4) were injected in the first experiment.‎ In the ‎second ‎experiment, the control solution (group1), 6-hydroxy-dopamine (6-OH-DA, 2.5 nmol, ‎‎group 2), noradrenaline (300 nmol, group 3), and 6-OH-DA + noradrenaline (group 4) ‎were ‎injected. The results showed that ICV injection of noradrenaline decreased food ‎intake (P<0.05). ‎Furthermore, co-injection of L-DOPA and noradrenaline significantly ‎amplified noradrenaline-induced hypophagia in neonatal chicks (P<0.05). In contrast, ‎co-injection of 6-OH-DA and ‎noradrenaline significantly reduced hypophagia induced ‎by noradrenaline in chicks (P<0.05). ‎According to the results, noradrenaline-induced ‎food intake is probably mediated by the ‎dopaminergic system in neonatal chickens.‎ Manuscript profile
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  2 - Synergistic Effects of Noradrenalin, Serotonin, and Oxytocin with Nesfatin on Central Control of Food Intake in Broiler Chickens
  Takrokh Ashtari tavandashti , Morteza , Zendehdel Mehdi Rahnema Shahin Hasanpour , Masoumeh Asle-Rousta
  Introduction & Objective: Appetite modulation is a set of physiological mechanisms that influence the various areas of the central nervous system. Noradrenaline, serotonin, and oxytocin have an important role in the central control of food intake in birds. On the ot More

  Introduction & Objective: Appetite modulation is a set of physiological mechanisms that influence the various areas of the central nervous system. Noradrenaline, serotonin, and oxytocin have an important role in the central control of food intake in birds. On the other hand, nesfatin decreases food intake in birds. Therefore, the aim of this study was to explain the synergistic effects of noradrenalin, serotonin, and oxytocin with nesfatin on food intake in neonatal broiler chickens.Materials and Methods: A total of one hundred and forty-four neonatal chicks were randomly divided into three experimental groups. Each experiment had a control group and three treatment groups (n=12 in each group). In all experiments, 3-hour food-deprived birds received intracerebroventricular ‎injections of either control diluent or drug solution. Then, the birds had ad libitum access to the ‎food and fresh water, and then cumulative food intake (gr) was measured based on the ‎percentage of the body. In the first experiment, normal saline, noradrenalin, nesfatin, and noradrenalin plus nesfatin were injected.‎ In the second experiment, normal saline, serotonin, nesfatin, and serotonin + nesfatin were injected. In the third experiment, normal saline, oxytocin, nesfatin, and oxytocin plus nesfatin were injected.Results: The results of the present study showed that co-injection of noradrenalin and nesfatin, serotonin plus nesfatin, and oxytocin plus nesfatin significantly reduced food intake in broiler chickens (P<0.05).Conclusion: According to the results of the present study, there is probably a synergistic effect between noradrenalin, serotonin, and oxytocin with nesfatin on food intake control of neonatal broiler chickens.  Manuscript profile