List of Articles Nesfatin

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  1 - The role of MC3/MC4 melanocortin receptors on food intake induced by nesfatin-1 in broilers
  A. Heidarzadeh, مرتضی Zendehdel, حسن Gilanpour وهاب Babapour,
  10.30495/jcp.2022.20938
  Food intake is a set of physiological mechanisms affecting different central nervous system areas. The melanocortin system plays an important role in the central control of food intake in birds. Nesfatin-1 reduces food intake in birds. The present study was conducted to More

  Food intake is a set of physiological mechanisms affecting different central nervous system areas. The melanocortin system plays an important role in the central control of food intake in birds. Nesfatin-1 reduces food intake in birds. The present study was conducted to investigate the effect of the melanocortin system on food intake caused by nesfatin-1 in broiler chickens. 36 broilers were randomly divided into three experimental groups. Each experiment included a control group and 3 treatment groups (12 chickens in each group). In all experiments, after 3 hours of food deprivation (FD3), chicks received either control diluent or drug solution by intracerebroventricular (I.C.V.) injection. Then the birds had ad libitum access to the ‎food and fresh water, and then cumulative food intake (gr) was measured based on the ‎percentage of the body (%BW). In the first experiment, chickens in the first group were given the control solution, the second group nesfatin-1 (40 ng), the third group SHU9119 (0.5 nmol, antagonist of MC3/MC4 receptors), and the fourth group nesfatin-1 + SHU9119 intracerebroventricularly was injected. In the second experiment, chickens in the first group were injected with the control solution, the second group with nesfatin-1 (40 ng), the third group with MCL0020 (0.5 nmol, MC4 receptor antagonist), and the fourth group with nesfatin-1+ MCL0020. In the third experiment, chickens in the first group were injected with the control solution, the second group with nesfatin-1 (10 ng), the third group with MTII (2.45 pmol, an agonist of MC3/MC4 receptors), and the fourth group with nesfatin-1+ MTII. The results showed that the injection of nesfatin-1 with a dose of 40 ng decreased food intake (p<0.05). Co-injection of nesfatin-1 and SHU9119 and co-injection of nesfatin-1 and MCL0020 inhibited the hypophagia caused by nesfatin-1 (p < 0.05). Injection of Nesfatin-1 with a dose of 10 ng and MTII with a dose of 2.45 pmol did not affect food intake (p > 0.05). While the co-injection of nesfatin-1 with a dose of 10 ng and MTII with a dose of 2.45 pmol reduced food intake (p < 0.05). According to the results, food intake caused by nesfatin-1 in broilers is probably mediated by the melanocortin system. Manuscript profile
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  2 - Synergistic Effects of Noradrenalin, Serotonin, and Oxytocin with Nesfatin on Central Control of Food Intake in Broiler Chickens
  Takrokh Ashtari tavandashti , Morteza , Zendehdel Mehdi Rahnema Shahin Hasanpour , Masoumeh Asle-Rousta
  Introduction & Objective: Appetite modulation is a set of physiological mechanisms that influence the various areas of the central nervous system. Noradrenaline, serotonin, and oxytocin have an important role in the central control of food intake in birds. On the ot More

  Introduction & Objective: Appetite modulation is a set of physiological mechanisms that influence the various areas of the central nervous system. Noradrenaline, serotonin, and oxytocin have an important role in the central control of food intake in birds. On the other hand, nesfatin decreases food intake in birds. Therefore, the aim of this study was to explain the synergistic effects of noradrenalin, serotonin, and oxytocin with nesfatin on food intake in neonatal broiler chickens.Materials and Methods: A total of one hundred and forty-four neonatal chicks were randomly divided into three experimental groups. Each experiment had a control group and three treatment groups (n=12 in each group). In all experiments, 3-hour food-deprived birds received intracerebroventricular ‎injections of either control diluent or drug solution. Then, the birds had ad libitum access to the ‎food and fresh water, and then cumulative food intake (gr) was measured based on the ‎percentage of the body. In the first experiment, normal saline, noradrenalin, nesfatin, and noradrenalin plus nesfatin were injected.‎ In the second experiment, normal saline, serotonin, nesfatin, and serotonin + nesfatin were injected. In the third experiment, normal saline, oxytocin, nesfatin, and oxytocin plus nesfatin were injected.Results: The results of the present study showed that co-injection of noradrenalin and nesfatin, serotonin plus nesfatin, and oxytocin plus nesfatin significantly reduced food intake in broiler chickens (P<0.05).Conclusion: According to the results of the present study, there is probably a synergistic effect between noradrenalin, serotonin, and oxytocin with nesfatin on food intake control of neonatal broiler chickens.  Manuscript profile
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  3 - Effect of Resveratrol Supplementation on Changes of Inflammatory Profile in Response to One Bout of Exhaustive Exercise in Sedentary Young Overweight Men
  mehdi salemi Najmeh Rezaeian
  10.30495/nssem.2023.1967095.1005
  Introduction: Nesfatin-1 and Apelin as two inflammatory adipocytokines affected by various stresses, including exercise. The purpose of this study was to investigate the effect of 14 days of resveratrol supplementation on changes in serum levels of Apelin and nesfatin-1 More

  Introduction: Nesfatin-1 and Apelin as two inflammatory adipocytokines affected by various stresses, including exercise. The purpose of this study was to investigate the effect of 14 days of resveratrol supplementation on changes in serum levels of Apelin and nesfatin-1 in response to one bout of exhaustive exercise in young sedentary overweight men. Methods: 20 young sedentary overweight men (mean aged= 35.7±3.26 years, BMI= 28.73±1.18 kg/m2) selected and randomly divided into two groups (experimental and control). Subjects in both experimental and control groups participated in one bout of exhaustive exercise (Bruce Test). Then, subjects in experimental group (supplementation) consumed one capsule of 400-mg resveratrol per day for 14 days. In control group (placebo), subject consumed one capsule of 400-mg lactose per day for 14 days. First blood sample was taken before the study and second one was done immediately after Bruce test. At the fifteenth day and at the end of 14 days of supplementation, subjects in both groups perform the exhaustive exercise again and forth blood sample was taken immediately following their performance. According to t-test, in the experimental group and following supplementation, changes in serum levels of Nesfatin-1 were significant in response to one bout of exhaustive exercise. However, following supplementation, there were significant differences between mean changes of Apelin levels in response to one bout of exhaustive exercise in experimental group compared to control group. According to Pearson correlation, there existed significant correlations between primary levels of Nesfatin-1 and primary values of body weight. Manuscript profile
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  4 - The Effect of Aerobic Exercise and Oral Consumption of Iranian Saffron Flower on Nesfatin-1 and Omentin-1 in Obese Women with Type 2 Diabetes
  Seyed Ebrahim Hosseini Ali Akbar Nezhad Fatemeh Shabkhiz Rahman Soori
  The aim of this study was to investigate the effect of aerobic exercise and oral consumption of Iranian saffron flower on Nesfatin-1 and Omentin-1 in obese women with type 2 diabetes. Forty-four people from the research community were randomly selected and divided into More

  The aim of this study was to investigate the effect of aerobic exercise and oral consumption of Iranian saffron flower on Nesfatin-1 and Omentin-1 in obese women with type 2 diabetes. Forty-four people from the research community were randomly selected and divided into four groups (11 people in each group) 1. supplement + exercise, 2. exercise + placebo, 3. placebo and 4. supplement. The training protocol in the first session included 20 minutes of activity with an intensity of 40 to 45% of the maximum heart rate, increased by 5 minutes every week for 9 weeks and 5% of the intensity of activity every two weeks. Due to the lack of regular physical activity and low physical fitness of these people, aerobic exercise started with a heart rate of 40-45% of the maximum heart rate and the intensity and duration of exercise increased gradually and continuously every week. The placebo and saffron supplement groups were asked not to exercise during this period. The amount of 200 mg of powdered saffron flower in capsules of the same color and shape with placebo capsules containing 200 mg of wheat flour was prepared. The results within the group indicated a significant difference between the pre-test and post-test of omentin-1 and nesfatin-1 in all groups except the placebo group (P≤0.05). Besides, the comparison of the results between groups in the variables of omentin-1 and nesfatin-1 showed a significant difference between all groups receiving the intervention in the post-test phase with the placebo group (P=0.0001). Although exercise has benefits in improving diabetics, but according to the results of the present study, supplementation with saffron extract can lead to a further increase in omentin-1 and nesfatin-1. Manuscript profile