Naringenin

Open Access Article

1 - A study of the effect of Naringinin derived amyloid and animal curvature and applied with 6-hydroxydopamine dermatosis in Parkinson's disease
BAHAR haghani Maryam khosravi jalal solati ramin haji

Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta More

Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta through a 30-gauge cannula. The group control1 received saline on the left side of the Substantia Nigra pars compacta.Then, to investigate the effect of the Naringenin, group control2 received distilled water and other groups received Naringenin via gavage for two weeks, and apomorphine induced rotation, catalepsy, and behavioral tests were assessed in all groups. Hematoxylin and eosin staining was performed and the percentage of the neurons on the left side of the Substantia Nigra pars compacta were calculated. In this study, in cell culture model, dopaminergic-like neurons cultured in DMEM medium were counted, and cells were used and incubated to evaluate the effect of naringinin against 6-hydroxy dopamine. Concentrations were 50 for 6-hydroxy dopamine solution and 0.25, 0.1 and 0.01 for NAR solution. Finally, cell viability was assessed using MTT and trypan blue methods.Results: 6-Hydroxy dopamine increased catalepsy and contralateral turns compared to the control group. Naringin reduced catalapsy and contralateral turns, it reduced anxiety and depressive-like behaviours besides that it increased swimming time and locomotor activity compared to the control group. Conclusion: it seems that Naringin is a therapeutic option for neurodegenerative disorders, such as Parkinson's disease. Manuscript profile

Open Access Article

2 - protective effect of Naringenin (Citrus flavonone) on incipient diabetic nephropathy in the rats with alloxan-induced diabetes
Yousef Doustar رامین Kaffash Elahi داریوش Mohajeri

Diabetes mellitus is a metabolic abnormality that has a relatively high prevalence all over the world. Kidney failure is one of the main complications of diabetes. Many therapeutic methods have been introduced from all over the world to treat diabetes. The aim of the pr More

Diabetes mellitus is a metabolic abnormality that has a relatively high prevalence all over the world. Kidney failure is one of the main complications of diabetes. Many therapeutic methods have been introduced from all over the world to treat diabetes. The aim of the present study was to assess the protective effect of Naringenin on early kidney injuries in alloxan-induced diabetic rats. Forty male Wistar rats were randomly allocated into 4 equal groups, including: healthy control, normal healthy receiving Naringenin, diabetic and diabetic receiving Naringenin. Diabetes was also induced by intraperitoneal injection of a single dose of naloxone (120 mg/kg). Naringenin treatment groups received the drug (50 mg/kg) daily for 3 weeks through the gavage. Finally, serum levels of kidney function markers including urea, uric acid and creatinine as well as amount of lipid peroxidation product (MDA) and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GR) were assessed in kidney hemogenates. Moreover, histopathological observation was assayed at the degree of renal injury. Significant differences among the groups were determined by one-way analysis of variance followed by Tukey post-test. Statistical significance was considered at p<0.05. In alloxanized diabetic rats, Naringenin significantly decreased the levels of serum urea, uric acid and creatinine (p<0.05), and significantly decreased the lipid peroxidation and elevated the levels of antioxidant enzymes in these rats (p<0.05). Histopathological changes were in agreement with biochemical findings. The results of the present study showed that naringenin with antioxidant properties can prevent early diabetic kidney damage. Manuscript profile

Open Access Article

3 - Study on protective effect of Naringenin (Citrus flavonone) on incipient diabetic hepatopathy in alloxan-induced diabetic rats
daryoush mohajeri ghafour mousavi ramin kaffashielahi mehrdad neshatgharamaleki

Abstract    Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. Hepatic insufficiency is one of the most important consequences in this disease. A multitude of drugs has been described for the treatment of More

Abstract    Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. Hepatic insufficiency is one of the most important consequences in this disease. A multitude of drugs has been described for the treatment of diabetes throughout the world. The aim of the present study was to assess the protective effect of Naringenin on early liver injury in alloxan-induced diabetic rats. Forty male Wistar rats were randomly assigned into 4 different groups of 10 rats each, including healthy control rats, normal healthy rats receiving Naringenin (50 mg/kg), diabetic rats and diabetic rats receiving Naringenin (50 mg/kg). Diabetes was induced with a single injection of alloxan (120 mg/kg i.p.). Naringenin groups received the drug daily for 3 weeks through gavage. At the end of the experiment, levels of liver function marker enzymes AST (Aspartate aminotransferase), ALT (Alanine aminotransferase) and ALP (Alkaline Phosphatase), TB (Total Bilirubin), Alb (Albumin) and TP (Total Proteins) were assessed in serum. Product of lipid peroxidation (Malondialdehyde; MDA), activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GR) were also assayed in liver homogenate to evaluate antioxidant activity. Moreover, histopathological observations were made to assess the degree of hepatic injury. In alloxanized diabetic rats, Naringenin significantly decreased the levels of serum biomarkers of hepatic injury and TB, and elevated the levels of Alb and TP. Furthermore, Naringenin significantly decreased the lipid peroxidation and elevated the levels of antioxidant enzymes in these rats. Histopathological changes were in agreement with biochemical findings. The findings of this study indicated that Naringenin due to its antioxidant activities protects rats liver from early diabetic hepatopathy. Manuscript profile

Open Access Article

4 - Preventive effects of Naringenin (Citrus flavonone) on intestinal ischemia–reperfusion injury in the rat
ghafour mousavi

The intestinal mucosa is known to be adversely affected by ischemia-reperfusion (I/R). It has been demonstrated that Naringenin has protective effects against ischemia-reperfusion injury in various organs. The aim of this study is to determine whether Naringenin has any More

The intestinal mucosa is known to be adversely affected by ischemia-reperfusion (I/R). It has been demonstrated that Naringenin has protective effects against ischemia-reperfusion injury in various organs. The aim of this study is to determine whether Naringenin has any protective role in I/R injury of the intestine in rats. For this purpose, forty male Wistar rats were randomly divided into four groups as control (group 1), sham IR (group 2), intestinal IR group (group 3) and Naringenin plus intestinal IR (group 4). Intestinal IR was produced by 30 minutes of intestinal ischemia followed by a 60 minutes of reperfusion. Rats in group 4 received Naringenin (20 mg/kg) intraperitoneally, 120 minutes before ischemia. After the experiments, the jejunum was removed and the tissues were processed for histopathological examination. Serum total antioxidant activity (TAA), and levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were measured in jejunal tissue. Histopathologically, jejunal tissues of the intestinal IR group showed severe inflammatory cell infiltration, villus shortening and blunting and hemorrhage in lamina propria, as well as epithelial cell necrosis. Administration of Naringenin alleviated the jejunal damage in group 4. Levels of TAA, SOD, CAT, GPx and GR decreased in the intestinal IR group, but increased significantly (p<0.05) in the IR+Naringenin group. Naringenin significantly (p<0.05) decreased MDA levels which was increased by IR. Our results showed that Naringenin treatment protected the rat's intestinal tissue against intestinal ischemia-reperfusion injury. Manuscript profile

Open Access Article

5 - بیان ژن ایزومراز کالکون در مراحل مختلف گل‌دهی اطلسی و رنگ‌های مختلف گل
فاطمه کیخا آخر عبدالرضا باقری نسرین مشتاقی مسعود فخرفشانی

اطلسی یکی از مهمترین گیاهان زینتی در صنعت گل و گیاهان زینتی است. این گیاه به عنوان یک گیاه مدل زینتی شناخته می شود و یکی از مهمترین گیاهان در بازار فروش گل می باشد. فلاونوئیدها یکی از اصلی ترین ترکیبات در این گیاه است. بنابراین مهندسی ژنتیک با هدف تغییر ر More

اطلسی یکی از مهمترین گیاهان زینتی در صنعت گل و گیاهان زینتی است. این گیاه به عنوان یک گیاه مدل زینتی شناخته می شود و یکی از مهمترین گیاهان در بازار فروش گل می باشد. فلاونوئیدها یکی از اصلی ترین ترکیبات در این گیاه است. بنابراین مهندسی ژنتیک با هدف تغییر رنگ گل در اطلسی بر این ترکیبات متمرکز شده است. برای بدست آوردن نمای کلی از بیان ژن ها در مسیر بیوسنتزی گیاه اطلسی، ما بیان ژن چالکون ایزومراز را در رنگ های مختلف و مراحل متفاوت گلدهی در این گیاه بررسی کردیم. همچنین برای بدست آوردن رابطه احتمالی بین بیان ژن و میزان این ترکیبات، غلظت فلاونوئیدهای کل، آنتوسیانین ها و نارنجنین اندازه گیری شد. نتایج نشان داد که بیان ژن چالکون ایزومراز در رنگ های مختلف اطلسی متفاوت بود. بطوری که بیشترین بیان ژن در اطلسی با رنگ گل قرمز مشاهده شد. همچنین غلظت نارنجنین در این رنگ گل بیشترین مقدار بود. در مقایسه با مراحل مختلف گلدهی، مرحله 1 بیشترین بیان را داشت. به عبارت دیگر هنگامی که گل ها به طور کامل بسته بودند (غنچه گل)، بیان و غلظت چالکون ایزومراز بیشترین مقدار بود. نتایج آزمایش ما نشان داد که چالکون ایزومراز یکی از ژن های کلیدی در مسیر بیوسنتزی تولید رنگ در این گیاه است به طوری که در غیاب این ژن، تولید رنگ متوقف خواهد شد. شناسایی ژن های موثر در مسیر تولید متابولیت های ثانویه در انتخاب صحیح ژن ها برای تغییر ژنتیکی آن ها و تولید متابولیت های ثانویه مختلف موثر خواهد بود. Manuscript profile

Open Access Article

6 - Synthesis of nanoporous molecularly imprinted polymers for extraction of naringenin compound
مینا هویه گر علیرضا امیری محسن جهانشاهی

In this research for the first time, an adsorbent based on molecularly imprinted polymers )MIPs( for selective extraction of Naringenin using methacrylic acid )functional polymer(, trimethylolpropane trimethacrylate )cross linker(, azobisisobutyronitrile )initiator( via More

In this research for the first time, an adsorbent based on molecularly imprinted polymers )MIPs( for selective extraction of Naringenin using methacrylic acid )functional polymer(, trimethylolpropane trimethacrylate )cross linker(, azobisisobutyronitrile )initiator( via precipitation polymerization technique in a ratio )1:4:20( were synthesized. After template removal, nanoporous imprinted polymeric lattice was prepared which is able to extract Naringenin as a bioactive compound from the mixtures containing this component. Non-imprinted polymers )NIPs( with the same materials )instead of the template molecule( were synthesized to compare the efficiency of the MIPs. Selectivity of the MIPs for Naringenin has been evaluated. Quercetin as a similar molecule of the template was selected which the binding capacity for Naringenin and Quercetin were 284 mg.g-1 and 70 mg.g-1, respectively. Imaging scanning electron microscope )SEM( was used for morphological studies on the synthesized polymer particles and brannauer-emmet-teller (BET) analysis method was applied to measure the porosity, specific surface area and poor diameters of the polymer Manuscript profile

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