Selenium is an important element in nutrition and an essential part of several proteins with catalytic and structural properties. Selenium nanoparticles have a higher effect and less toxicity than conventional selenium. The aim of this study was to demonstrate the stron More
Selenium is an important element in nutrition and an essential part of several proteins with catalytic and structural properties. Selenium nanoparticles have a higher effect and less toxicity than conventional selenium. The aim of this study was to demonstrate the strong role of nano-selenium in protecting against ischemia/reperfusion (I/R) injury in a male rat model. In this study, I/R damage was caused by closing the left renal artery for 20 minutes. 54 rats were randomly divided into 9 healthy control groups, Sham, three healthy experimental groups receiving selenium nanoparticle at doses of 0.25, 0.5 and 1 mg/kg alone, I/R control and three groups of I/R mice receiving selenium nanoparticle at doses above, were divided (n=6). Thirty days after administration, animals were sacrificed for biochemical and histopathological evaluation and the data were statistically analyzed (p˂0.05). Selenium nanoparticle in I/R groups significantly decreased serum urea and creatinine levels (p˂0.001) and significantly increased the antioxidant parameters of catalase, glutathione peroxidase and superoxide dismutase and significantly decreased the level of malondialdehyde (p˂0.001) to 0/1. I/R and repair of renal histological damage (p˂0.001). This study showed that selenium nanoparticle has protective effects against damage caused by renal ischemic reperfusion, and this protective effect can be due to its antioxidant properties in improving damage caused by free radicals in the ischemic reperfusion process, thereby improving the structure of kidney’s tissue and reduce oxidative stress.
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Background & Objectives: Selenium nanoparticles have a wide range application in industry, biomedical and environmental fields due to their unique physical, chemical and photoelectrical properties. This study was aimed to use aquatic bacteria in bioreduction of sele More
Background & Objectives: Selenium nanoparticles have a wide range application in industry, biomedical and environmental fields due to their unique physical, chemical and photoelectrical properties. This study was aimed to use aquatic bacteria in bioreduction of selenite oxyanioninto elemental nano-selenium. Materials & Methods: Synthesized selenium nanoparticles were characterized by spectroscopic analysis and electromicrographs prepared by scanning electron microscopy (SEM). The efficacy of the antimicrobial activity of the synthesized selenium nanoparticles against some Gram-positive and Gram-negative human pathogenic bacteria was also investigated by the agar well diffusion test. Results: Sixteen selenite-resistant bacterial strains were isolated based on selective enrichment techniques in Tryptic Soy Agar (TSA) medium containing 5 mM selenite ion. Our results showed that Pseudomonas alcaligenes SR5 coastal seawater isolate can reduce selenite oxyanion into selenium nanoparticles. Furthermore, the results showed that extracellular selenium nanoparticles with an average size of 36 nm were formed in an optimum selenite concentration of 3 mM and an optimum initial biomass concentration of 15 g/l, following 96 h incubation at 25ᵒ C at (200 rpm under resting cell condition. Conclusion: The current study is the first report on extracellular synthesis of selenium nanoparticles using P. alcaligenes. The produced bio-nanoparticles showed a growth inhibitory effect against four tested pathogenic bacterial strains.
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The purpose of this study was to investigate the effects of replacing mineral selenium supplement with nano selenium particles in the feeding of infant calves and its effects on nutrient digestibility, rumen fermentation characteristics, blood metabolites, and improving More
The purpose of this study was to investigate the effects of replacing mineral selenium supplement with nano selenium particles in the feeding of infant calves and its effects on nutrient digestibility, rumen fermentation characteristics, blood metabolites, and improving the growth performance and skeletal structure of infant calves. The number of 32 newborn Holstein calves with an average body weight of 37.85 ± 4.35 kg in the form of a completely randomized design with 4 treatments (eight calves in each treatment) for 83 days according to the supplemental consumption of milk or drinking water with sources Different selenium were placed. Treatments include: 1) inorganic selenium: providing 0.3 mg of selenium per kilogram of dry matter with sodium selenite, 2) low level of nano selenium: providing 0.15 mg of selenium per kilogram of dry matter with nanoparticles prepared from selenium, 3 (Medium level of nano-selenium: providing 0.3 mg of selenium per kilogram of dry matter with nanoparticles prepared from selenium, 4) High level of nano-selenium: providing 0.45 mg of selenium per kilogram of dry matter with nanoparticles prepared from selenium. . The results showed that supplementing milk with selenium nanoparticles had no effect on the performance of calves during the pre-weaning period, but significantly improved it after weaning compared to calves that were fed sodium selenite. The feed efficiency in the second period increased exponentially (P<0.01) and the average level was the highest. Improve the digestibility of protein and insoluble fibers in neutral detergent with nanoselenium. Some parameters of skeletal growth were improved by supplementation with selenium nanoparticles.
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