• List of Articles Liver damage

      • Open Access Article

        1 - Protective effects of Silymarin on Cell-Phone Induced Liver Damage in Rats
        ََAmir Ashkan Mahjoor
        Inroduction & Objective: Different studies have demonstrated the effects of cell phone induced electromagnetic field on hepatic cells. The aim of this study was to investigate the hrpatoprotective effects of silymarin on this kind of damagesMaterial and MethodsSeventy r More
        Inroduction & Objective: Different studies have demonstrated the effects of cell phone induced electromagnetic field on hepatic cells. The aim of this study was to investigate the hrpatoprotective effects of silymarin on this kind of damagesMaterial and MethodsSeventy rats were divided in five groups. One control group and four exposure groups that were exposed to cell phone radiation 5 times a day for 30 days each time 10 minutes. At the end of the study all of the rats were sacrificed and Alanine Aminotransferase (ALT), aspartate aminotransferase (AST) and Alkaline Phosphatase (ALP), total proptein, total bilirubin and albumin were measured. Liver samples were obtained for histopathological studiesResults: Cell phone radiation significantly (P≤005) increased levels of ALT, AST, ALP, total bilirubin  and decreased levels of total protein and albumin. In groups treated with silymarin improve in biochemical factors were noted. Histopathological findings were consistent with biochemical findingsConclusion:Our results suggest that silymarin has hepatoprotective effects on cell phone induced liver damaged due to free radical scavenger and antioxidant Manuscript profile
      • Open Access Article

        2 - Hypolipidemic effect of dill essential oil in hyperlipidemic rats
        Tayebeh Moradkhani Maryam Eidi Alireza Saeedinia
        Hyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of essential oil dill on the lipid profile in hyperlipidemic rats. Thirty-six adult male rats were divided into 6 groups including nor More
        Hyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of essential oil dill on the lipid profile in hyperlipidemic rats. Thirty-six adult male rats were divided into 6 groups including normal group, control hyperlipidemic group (received 10% lipid in food), hyperlipidemic rats (received atorvastatin at dose of 10 mg/kg, daily) and experimental hyperlipidemic rats (received essential oil of dill at doses 0.5, 1 and 2 ml/kg, daily). After 8 weeks and 12 h fastening, the animals were weighted and anesthetized by ether. The blood and liver sampling was done. The serum cholesterol, triglyceride, LDL, HDL, VLDL, AST and ALT levels were measured by kit. The liver sections were stained by haematocilin-eosin method. The result showed that oral treatment of atorvastatin and essential oil of dill decreased weight gain, serum cholesterol, triglyceride, LDL, VLDL, AST and ALT levels and liver damaged, while increased serum HDL level in experimental rats in comparison to control hyperlipidemic rats, significantly. So, essential oil of dill improved lipid profile in hyperlipidemic animal and has antioxidant effect with improving liver tissue and function. Manuscript profile
      • Open Access Article

        3 - Liver Damage Risk Assessment Study in Workers Occupationally Exposed to E-waste in Benin City, South-South Nigeria
        John I. Anetor Oladele O. Osibanjo Humphrey Benedo Osadolor Festus A. Idomeh Williams Osazee Igiewe Ogochukwu Uzoma Kalikwu